November 23, 2009

Tracking the Total CD8 T Cell Response to Infection Reveals Substantial Discordance in Magnitude and Kinetics between Inbred and Outbred Hosts

Deepa Rai, Nhat-Long L. Pham, John T. Harty, and Vladimir P. Badovinac
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0902874 [Abstract] [PDF]  

Accumulation of CD11b⁺ Lung Dendritic Cells in Response to Fungal Infection Results from the CCR2-Mediated Recruitment and Differentiation of Ly-6C^high Monocytes

John J. Osterholzer, Gwo-Hsiao Chen, Michal A. Olszewski, Jeffrey L. Curtis, Gary B. Huffnagle, and Galen B. Toews
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0902823 [Abstract] [PDF]  

Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production

Caroline R. Boyd, Selinda J. Orr, Shaun Spence, James F. Burrows, Joanne Elliott, Helen P. Carroll, Kiva Brennan, Joan Ní Gabhann, Wilson A. Coulter, James A. Johnston, and Caroline A. Jefferies
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0902780 [Abstract] [PDF] [Data Supplement]  

Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction

Danielle F. Atibalentja, Craig A. Byersdorfer, and Emil R. Unanue
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0902632 [Abstract] [PDF] [Data Supplement]  

Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens

Qian Hu, Alyssa Sader, Julia C. Parkman, and Troy A. Baldwin
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0902181 [Abstract] [PDF] [Data Supplement]  

β-Defensins 2 and 3 Together Promote Resistance to P. aeruginosa Keratitis

Minhao Wu, Sharon A. McClellan, Ronald P. Barrett, Yunfan Zhang, and Linda D. Hazlett
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0902140 [Abstract] [PDF]  

Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1-Induced Chemotaxis in T Cells

Yuichi Sekine, Osamu Ikeda, Satoshi Tsuji, Chikako Yamamoto, Ryuta Muromoto, Asuka Nanbo, Kenji Oritani, Akihiko Yoshimura, and Tadashi Matsuda
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0902096 [Abstract] [PDF]  

RasGRP1 Is Required for Human NK Cell Function

Suk Hyung Lee, Sohyun Yun, Jiwon Lee, Mi Jeong Kim, Zheng-Hao Piao, Mira Jeong, Jin Woong Chung, Tae-Don Kim, Suk Ran Yoon, Philip D. Greenberg, and Inpyo Choi
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0902012 [Abstract] [PDF] [Data Supplement]  

In a Murine Tuberculosis Model, the Absence of Homeostatic Chemokines Delays Granuloma Formation and Protective Immunity

Shabaana A. Khader, Javier Rangel-Moreno, Jeffrey J. Fountain, Cynthia A. Martino, William W. Reiley, John E. Pearl, Gary M. Winslow, David L. Woodland, Troy D. Randall, and Andrea M. Cooper
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0901937 [Abstract] [PDF]  

TLR2 Engagement on Dendritic Cells Promotes High Frequency Effector and Memory CD4 T Cell Responses

Smita S. Chandran, David Verhoeven, John R. Teijaro, Matthew J. Fenton, and Donna L. Farber
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0901683 [Abstract] [PDF]  

The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling

Sandrine Crabé, Angélique Guay-Giroux, Aurélie Jeanne Tormo, Dorothée Duluc, Rami Lissilaa, Florence Guilhot, Ulrick Mavoungou-Bigouagou, Fouad Lefouili, Isabelle Cognet, Walter Ferlin, Greg Elson, Pascale Jeannin, and Jean-François Gauchat
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0901464 [Abstract] [PDF] [Data Supplement]  

Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1β Production

Lisa A. Mielke, Karen L. Elkins, Lai Wei, Robyn Starr, Philip N. Tsichlis, John J. O'Shea, and Wendy T. Watford
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0901336 [Abstract] [PDF] [Data Supplement]  

Human Activated T Lymphocytes Modulate IDO Expression in Tumors through Th1/Th2 Balance

Jessica Godin-Ethier, Sandy Pelletier, Laïla-Aïcha Hanafi, Philippe O. Gannon, Marie-Andrée Forget, Jean-Pierre Routy, Mohamed-Rachid Boulassel, Urszula Krzemien, Simon Tanguay, Jean-Baptiste Lattouf, Nathalie Arbour, and Réjean Lapointe
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0901004 [Abstract] [PDF] [Data Supplement]  

Activation, Immune Polarization, and Graft-versus-Leukemia Activity of Donor T Cells Are Regulated by Specific Subsets of Donor Bone Marrow Antigen-Presenting Cells in Allogeneic Hemopoietic Stem Cell Transplantation

Jian-Ming Li, Lauren T. Southerland, Ying Lu, Kataryna A. Darlak, Cynthia R. Giver, Douglas W. McMillin, Wayne A.C. Harris, David L. Jaye, and Edmund K. Waller
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0900155 [Abstract] [PDF] [Data Supplement]  

Ubiquitin Conjugation of ORFF DNA Vaccine Leads to Enhanced Cell-Mediated Immune Response and Induces Protection against Both Antimony-Susceptible and -Resistant Strains of Leishmania donovani

Ankur Sharma and Rentala Madhubala
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0900132 [Abstract] [PDF]  

The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8⁺ T Cell Response

Rama S. Akondy, Nathan D. Monson, Joseph D. Miller, Srilatha Edupuganti, Dirk Teuwen, Hong Wu, Farah Quyyumi, Seema Garg, John D. Altman, Carlos Del Rio, Harry L. Keyserling, Alexander Ploss, Charles M. Rice, Walter A. Orenstein, Mark J. Mulligan, and Rafi Ahmed
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0803903 [Abstract] [PDF] [Data Supplement]  

B7-1/2 (CD80/CD86) Direct Signaling to B Cells Enhances IgG Secretion

Friederike C. Rau, Jacquelyn Dieter, Zhang Luo, Stephen O. Priest, and Nicole Baumgarth
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0803783 [Abstract] [PDF]  

Sublingual Immunization with Nonreplicating Antigens Induces Antibody-Forming Cells and Cytotoxic T Cells in the Female Genital Tract Mucosa and Protects against Genital Papillomavirus Infection

Nicolas Çuburu, Mi-Na Kweon, Catherine Hervouet, Hye-Ran Cha, Yuk-Ying S. Pang, Jan Holmgren, Konrad Stadler, John T. Schiller, Fabienne Anjuère, and Cecil Czerkinsky
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0803740 [Abstract] [PDF]  

The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA3

Kazuyoshi Kohu, Hidetaka Ohmori, Won Fen Wong, Daisuke Onda, Takeshi Wakoh, Shunsuke Kon, Masakatsu Yamashita, Toshinori Nakayama, Masato Kubo, and Masanobu Satake
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0802527 [Abstract] [PDF] [Data Supplement]  

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

Tatsukuni Ohno, Keisuke Oboki, Naoki Kajiwara, Eiichi Morii, Katsuyuki Aozasa, Richard A. Flavell, Ko Okumura, Hirohisa Saito, and Susumu Nakae
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0802449 [Abstract] [PDF]  

The Heavy Chain Variable Segment Gene Repertoire in Chronic Chagas' Heart Disease

Vanina Grippo, Evelyn Mahler, Fernando E. Elias, Ana Cauerhff, Karina A. Gómez, Maria C. Tentori, Aurora Ruiz, Carlos A. Vigliano, Ruben P. Laguens, Claudia Berek, and Mariano J. Levin
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0802375 [Abstract] [PDF] [Data Supplement]  

Modulation of Allergenicity of Major House Dust Mite Allergens Der f 1 and Der p 1 by Interaction with an Endogenous Ligand

Toshiro Takai, Takeshi Kato, Hideki Hatanaka, Kyoko Inui, Takuya Nakazawa, Saori Ichikawa, Kouichi Mitsuishi, Hideoki Ogawa, and Ko Okumura
J Immunol. published online November 23, 2009, doi:10.4049/jimmunol.0713276 [Abstract] [PDF]  

November 18, 2009

Distinct Antiviral Roles for Human 2',5'-Oligoadenylate Synthetase Family Members against Dengue Virus Infection

Ren-Jye Lin, Han-Pang Yu, Bi-Lan Chang, Wei-Chun Tang, Ching-Len Liao, and Yi-Ling Lin
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902728 [Abstract] [PDF]  

The Tpl2 Mutation Sluggish Impairs Type I IFN Production and Increases Susceptibility to Group B Streptococcal Disease

Nengming Xiao, Celine Eidenschenk, Philippe Krebs, Katharina Brandl, Amanda L. Blasius, Yu Xia, Kevin Khovananth, Nora G. Smart, and Bruce Beutler
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902718 [Abstract] [PDF] [Data Supplement]  

Langerin⁺CD8⁺ Dendritic Cells Are Critical for Cross-Priming and IL-12 Production in Response to Systemic Antigens

Kathryn J. Farrand, Nina Dickgreber, Patrizia Stoitzner, Franca Ronchese, Troels R. Petersen, and Ian F. Hermans
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902707 [Abstract] [PDF]  

Activated CD8⁺ T-Effector/Memory Cells Eliminate CD4⁺ CD25⁺ Foxp3⁺ T-Suppressor Cells from Tumors via FasL Mediated Apoptosis

Mehmet O. Kilinc, Rachael B. Rowswell-Turner, Tao Gu, Lauren P. Virtuoso, and Nejat K. Egilmez
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902625 [Abstract] [PDF]  

New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

Elise Landais, Pablo A. Romagnoli, Adam L. Corper, John Shires, John Altman, Ian A. Wilson, K. Christopher Garcia, and Luc Teyton
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902493 [Abstract] [PDF] [Data Supplement]  

Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis

Qunzhou Zhang, Shihong Shi, Yi Liu, Jettie Uyanne, Yufang Shi, Songtao Shi, and Anh D. Le
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902318 [Abstract] [PDF] [Data Supplement]  

Viruses within the Flaviviridae Decrease CD4 Expression and Inhibit HIV Replication in Human CD4⁺ Cells

Jinhua Xiang, James H. McLinden, Robert A. Rydze, Qing Chang, Thomas M. Kaufman, Donna Klinzman, and Jack T. Stapleton
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902276 [Abstract] [PDF] [Data Supplement]  

An Innate Response to Allogeneic Nonself Mediated by Monocytes

Daniel Zecher, Nico van Rooijen, David M. Rothstein, Warren D. Shlomchik, and Fadi G. Lakkis
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902194 [Abstract] [PDF] [Data Supplement]  

Duality of Enhancer Functioning Mode Revealed in a Reduced TCRβ Gene Enhancer Knockin Mouse Model

Marie Bonnet, Fang Huang, Touati Benoukraf, Olivier Cabaud, Christophe Verthuy, Anaelle Boucher, Sébastien Jaeger, Pierre Ferrier, and Salvatore Spicuglia
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902179 [Abstract] [PDF] [Data Supplement]  

IL-7 Enhances Thymic Human T Cell Development in "Human Immune System" Rag2^–/–IL-2R_c^–/– Mice without Affecting Peripheral T Cell Homeostasis

Anja U. van Lent, Wendy Dontje, Maho Nagasawa, Rachida Siamari, Arjen Q. Bakker, Stephan M. Pouw, Kelly A. Maijoor, Kees Weijer, Jan J. Cornelissen, Bianca Blom, James P. Di Santo, Hergen Spits, and Nicolas Legrand
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902019 [Abstract] [PDF] [Data Supplement]  

CCR7 Modulates Pulmonary and Lymph Node Inflammatory Responses in Cigarette Smoke-Exposed Mice

Tine Demoor, Ken R. Bracke, Karim Y. Vermaelen, Lisa Dupont, Guy F. Joos, and Guy G. Brusselle
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0902015 [Abstract] [PDF]  

Matrix Metalloproteinase (MMP)-1 and MMP-3 Induce Macrophage MMP-9: Evidence for the Role of TNF- and Cyclooxygenase-2

Michel Steenport, K. M. Faisal Khan, Baoheng Du, Sarah E. Barnhard, Andrew J. Dannenberg, and Domenick J. Falcone
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0901925 [Abstract] [PDF]  

Cutting Edge: Inhibitory Effects of CD4 and CD8 on T Cell Activation Induced by High-Affinity, Noncognate Ligands

Adam S. Chervin, Jennifer D. Stone, Natalie A. Bowerman, and David M. Kranz
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0901664 [Abstract] [PDF] [Data Supplement]  

IL-23 Is Required for Protection against Systemic Infection with Listeria monocytogenes

Karen D. Meeks, Amy N. Sieve, Jay K. Kolls, Nico Ghilardi, and Rance E. Berg
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0901588 [Abstract] [PDF]  

Brain-Derived Neurotrophic Factor (BDNF) Induces Sustained Elevation of Intracellular Ca²⁺ in Rodent Microglia

Yoshito Mizoguchi, Akira Monji, Takahiro Kato, Yoshihiro Seki, Leo Gotoh, Hideki Horikawa, Satoshi O. Suzuki, Toru Iwaki, Miyuki Yonaha, Sadayuki Hashioka, and Shigenobu Kanba
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0901326 [Abstract] [PDF]  

IFN- Expressed by T Cells Regulates the Persistence of Antigen Presentation by Limiting the Survival of Dendritic Cells

Marsha S. Russell, Renu Dudani, Lakshmi Krishnan, and Subash Sad
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0901274 [Abstract] [PDF]  

Signaling Crosstalk during Sequential TLR4 and TLR9 Activation Amplifies the Inflammatory Response of Mouse Macrophages

Dominic De Nardo, Christine M. De Nardo, Thao Nguyen, John A. Hamilton, and Glen M. Scholz
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0901031 [Abstract] [PDF]  

Enhanced Susceptibility to Leishmania Infection in Resistant Mice in the Absence of Immediate Early Response Gene X-1

Oleg E. Akilov, Irina V. Ustyugova, Liang Zhi, Tayyaba Hasan, and Mei X. Wu
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0900866 [Abstract] [PDF] [Data Supplement]  

CD69 Controls the Pathogenesis of Allergic Airway Inflammation

Takako Miki-Hosokawa, Akihiro Hasegawa, Chiaki Iwamura, Kenta Shinoda, Soichi Tofukuji, Yukiko Watanabe, Hiroyuki Hosokawa, Shinichiro Motohashi, Kahoko Hashimoto, Mutsunori Shirai, Masakatsu Yamashita, and Toshinori Nakayama
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0900646 [Abstract] [PDF]  

Soluble B and T Lymphocyte Attenuator Possesses Antitumor Effects and Facilitates Heat Shock Protein 70 Vaccine-Triggered Antitumor Immunity against a Murine TC-1 Cervical Cancer Model In Vivo

Lingfei Han, Wei Wang, Yong Fang, Zuohua Feng, Shujie Liao, Wei Li, Yan Li, Chunxiao Li, Mayinuer Maitituoheti, Hong Dong, Zhiwen Lai, Qinglei Gao, Ling Xi, Mingfu Wu, Daowen Wang, Jianfeng Zhou, Li Meng, Shixuan Wang, and Ding Ma
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0804379 [Abstract] [PDF] [Data Supplement]  

Cutting Edge: Depletion of Foxp3⁺ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice1

Jeong Kim, Katharina Lahl, Shohei Hori, Christoph Loddenkemper, Ashutosh Chaudhry, Paul deRoos, Alexander Rudensky, and Tim Sparwasser
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0804308 [Abstract] [PDF] [Data Supplement]  

Cutting Edge: Normal Regional Lymph Node Enrichment of Antigen-Specific Regulatory T Cells with Autoimmune Disease-Suppressive Capacity

Karen M. Wheeler, Eileen T. Samy, and Kenneth S. K. Tung
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0804251 [Abstract] [PDF] [Data Supplement]  

Autoimmune Regulator Deficiency Results in Decreased Expression of CCR4 and CCR7 Ligands and in Delayed Migration of CD4⁺ Thymocytes

Martti Laan, Kai Kisand, Vivian Kont, Kaidi Möll, Liina Tserel, Hamish S. Scott, and Pärt Peterson
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0804133 [Abstract] [PDF]  

Infection with Arginase-Deficient Leishmania major Reveals a Parasite Number-Dependent and Cytokine-Independent Regulation of Host Cellular Arginase Activity and Disease Pathogenesis

Helen M. Muleme, Rosa M. Reguera, Alicia Berard, Richard Azinwi, Ping Jia, Ifeoma B. Okwor, Stephen Beverley, and Jude E. Uzonna
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0803979 [Abstract] [PDF]  

Integration of Distinct Intracellular Signaling Pathways at Distal Regulatory Elements Directs T-bet Expression in Human CD4⁺ T Cells

Katarzyna Placek, Sona Gasparian, Maryaline Coffre, Sylvie Maiella, Emmanuel Sechet, Elisabetta Bianchi, and Lars Rogge
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0803812 [Abstract] [PDF] [Data Supplement]  

Neutrophils and Macrophages Cooperate in Host Resistance against Leishmania braziliensis Infection

Fernanda O. Novais, Rômulo C. Santiago, André Báfica, Ricardo Khouri, Lilian Afonso, Valéria M. Borges, Cláudia Brodskyn, Manoel Barral-Netto, Aldina Barral, and Camila I. de Oliveira
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0803720 [Abstract] [PDF] [Data Supplement]  

Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption

Keiichi Koizumi, Yurika Saitoh, Takayuki Minami, Nobuhiro Takeno, Koichi Tsuneyama, Tatsuro Miyahara, Takashi Nakayama, Hiroaki Sakurai, Yasuo Takano, Miyuki Nishimura, Toshio Imai, Osamu Yoshie, and Ikuo Saiki
J Immunol. published online November 18, 2009, doi:10.4049/jimmunol.0803627 [Abstract] [PDF]  

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