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Future Table of Contents: Volume 181 / No. 9 / Nov 1, 2008

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

The `Bubble Boy' Paradox: An Answer That Led to a Question

Leslie J. Berg

Pillars Article: Interleukin-2 Receptor Chain Mutation Results in X-Linked Severe Combined Immunodeficiency in Humans. Cell 73: 147-157.

Masayuki Noguchi, Huafang Yi, Howard M. Rosenblatt, Alexandra H.Filipovich, Stephen Adelstein, William S. Modi, O. Wesley McBride, and Warren J. Leonard

BRIEF REVIEWS

Macrophages as APC and the Dendritic Cell Myth

David A. Hume

CUTTING EDGE

Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues

Linda Wakim, Thomas Gebhardt, William R. Heath, and Francis R. Carbone

IFN- Enables Antigen-Presenting Cells to Promote Memory Th17 and Abate Th1 Cell Development

Ilona Kryczek, Shuang Wei, Wenrong Gong, Xiaogong Shu, Wojciech Szeliga, Linhua Vatan, Lieping Chen, Guobin Wang, and Weiping Zou

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Jakmip1 Is Expressed upon T Cell Differentiation and Has an Inhibitory Function in Cytotoxic T Lymphocytes

Valentina Libri, Dorte Schulte, Amber van Stijn, Josiane Ragimbeau, Lars Rogge, and Sandra Pellegrini

NF-B Modulates Sensitivity to Apoptosis, Proinflammatory, and Migratory Potential in Short- vs Long-Term Cultured Human Lymphocytes

Marina Ferrarini, Fanny Delfanti, Monica Gianolini, Chiara Rizzi, Massimo Alfano, Adriano Lazzarin, and Priscilla Biswas

A Complex Interplay among Virus, Dendritic Cells, T Cells, and Cytokines in Dengue Virus Infections

Wanwisa Dejnirattisai, Thaneeya Duangchinda, Chen-Lung Steve Lin, Sirijitt Vasanawathana, Meleri Jones, Michael Jacobs, Prida Malasit, Xiao-ning Xu, Gavin Screaton, and Juthathip Mongkolsapaya

Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN-

Melissa B. Uccellini, Liliana Busconi, Nathaniel M. Green, Patricia Busto, Sean R. Christensen, Mark J. Shlomchik, Ann Marshak-Rothstein, and Gregory A. Viglianti

E47 Controls the Developmental Integrity and Cell Cycle Quiescence of Multipotential Hematopoietic Progenitors

Qi Yang, Lela Kardava, Anthony St. Leger, Kathleen Martincic, Barbara Varnum-Finney, Irwin D. Bernstein, Christine Milcarek, and Lisa Borghesi

Pathogenic Effector T Cell Enrichment Overcomes Regulatory T Cell Control and Generates Autoimmune Gastritis

Joao P. Monteiro, Julia Farache, Ana Carolina Mercadante, Julio A. Mignaco, Martin Bonamino, and Adriana Bonomo

A Quantitative Trait Locus on Chromosome 4 Affects Cycling of Hematopoietic Stem and Progenitor Cells through Regulation of TGF-2 Responsiveness

Serine Avagyan, Ludmila Glouchkova, Juhyun Choi, and Hans-Willem Snoeck

Fas Expression on Antigen-Specific T Cells Has Costimulatory, Helper, and Down-Regulatory Functions In Vivo for Cytotoxic T Cell Responses but Not for T Cell-Dependent B Cell Responses

Irina Puliaeva, Roman Puliaev, Andrei Shustov, Mark Haas, and Charles S. Via

SIT and TRIM Determine T Cell Fate in the Thymus

Uwe Koelsch, Burkhart Schraven, and Luca Simeoni

Identification of CD25+ T Cells As Fetal Thymus-Derived Naturally Occurring IL-17 Producers

Kensuke Shibata, Hisakata Yamada, Risa Nakamura, Xun Sun, Momoe Itsumi, and Yasunobu Yoshikai

IL-23 Promotes Maintenance but not Commitment to the Th17 Lineage

Gretta L. Stritesky, Norman Yeh, and Mark H. Kaplan

Experimental Extracorporeal Photopheresis Inhibits the Sensitization and Effector Phases of Contact Hypersensitivity via Two Mechanisms: Generation of IL-10 and Induction of Regulatory T Cells

Akira Maeda, Agatha Schwarz, Ann Bullinger, Akimichi Morita, David Peritt, and Thomas Schwarz

Rho-ROCK-Dependent Ezrin-Radixin-Moesin Phosphorylation Regulates Fas-Mediated Apoptosis in Jurkat Cells

Marylise Hebert, Sophie Potin, Michael Sebbagh, Jacques Bertoglio, Jacqueline Breard, and Jocelyne Hamelin

Heterospecific CD4 Help to Rescue CD8 T Cell Killers

Marie-Ghislaine de Goer de Herve, Anne Cariou, Federico Simonetta, and Yassine Taoufik

An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor

Maho Suzukawa, Motoyasu Iikura, Rikiya Koketsu, Hiroyuki Nagase, Chise Tamura, Akiko Komiya, Susumu Nakae, Kouji Matsushima, Ken Ohta, Kazuhiko Yamamoto, and Masao Yamaguchi

TCR Complex-Activated CD8 Adhesion Function by Human T Cells

Jay C. Varghese and Kevin P. Kane

OX40 Costimulatory Signals Potentiate the Memory Commitment of Effector CD8+ T Cells

Seyed Fazlollah Mousavi, Pejman Soroosh, Takeshi Takahashi, Yasunobu Yoshikai, Hao Shen, Leo Lefrancois, Jannie Borst, Kazuo Sugamura, and Naoto Ishii

Calcitonin Gene-Related Peptide Biases Langerhans Cells toward Th2-Type Immunity

Wanhong Ding, Lori Stohl, John A. Wagner, and Richard D. Granstein

Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype

Cyril Fauriat, Sandra Andersson, Andreas Bjorklund, Mattias Carlsten, Marie Schaffer, Niklas K. Bjorkstrom, Bettina C. Baumann, Jakob Michaelsson, Hans-Gustaf Ljunggren, and Karl-Johan Malmberg

Intraclonal Competition Inhibits the Formation of High-Affinity Antibody-Secreting Cells

Thuc-vy L. Le, Tea Hyun Kim, and David D. Chaplin

Nasal Anti-CD3 Antibody Ameliorates Lupus by Inducing an IL-10-Secreting CD4+CD25-LAP+ Regulatory T Cell and Is Associated with Down-Regulation of IL-17+CD4+ICOS+CXCR5+ Follicular Helper T Cells

Henry Yim Wu, Francisco J. Quintana, and Howard L. Weiner

IL-24 Induces Apoptosis of Chronic Lymphocytic Leukemia B Cells Engaged into the Cell Cycle through Dephosphorylation of STAT3 and Stabilization of p53 Expression

Alexander Sainz-Perez, Helene Gary-Gouy, Francoise Gaudin, Ghyath Maarof, Anne Marfaing-Koka, Thierry de Revel, and Ali H. Dalloul

Soluble Frizzled-Related Protein 1 Is Estrogen Inducible in Bone Marrow Stromal Cells and Suppresses the Earliest Events in Lymphopoiesis

Takafumi Yokota, Kenji Oritani, Karla P. Garrett, Taku Kouro, Makoto Nishida, Isao Takahashi, Michiko Ichii, Yusuke Satoh, Paul W. Kincade, and Yuzuru Kanakura

Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H3

Yasuhiro Nagai, Hisashi Aso, Hideki Ogasawara, Sachi Tanaka, Yoshikazu Taketa, Kouichi Watanabe, Shyuichi Ohwada, Michael T. Rose, Haruki Kitazawa, and Takahiro Yamaguchi

Selective Regulation of TCR Signaling Pathways by the CD45 Protein Tyrosine Phosphatase during Thymocyte Development

Rustom Falahati and David Leitenberg

An Epithelial Progenitor Pool Regulates Thymus Growth

William E. Jenkinson, Andrea Bacon, Andrea J. White, Graham Anderson, and Eric J. Jenkinson

Central Tolerance Regulates B Cells Reactive with Goodpasture Antigen 3(IV)NC1 Collagen

Ying Zhang, Susan C. Su, Douglas B. Hecox, Graham F. Brady, Katherine M. Mackin, Amy G. Clark, and Mary H. Foster

Endothelial Expression of CD86 on Human Islet Endothelial Cells Facilitates T Cell Adhesion and Migration

Biliana Lozanoska-Ochser, Nigel J. Klein, Guo C. Huang, Raymond A. Alvarez, and Mark Peakman

IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma

Chuanwang Song, Liqiong Luo, Zhang Lei, Bo Li, Zhihui Liang, Guanghui Liu, Dong Li, Guimei Zhang, Bo Huang, and Zuo-Hua Feng

Selective Expression Rather Than Specific Function of Txk and Itk Regulate Th1 and Th2 Responses

Nisebita Sahu, Ana M. Venegas, Dragana Jankovic, Wayne Mitzner, Julio Gomez-Rodriguez, Jennifer Cannons, Connie Sommers, Paul Love, Alan Sher, Pamela L. Schwartzberg, and Avery August

Critical Role of TLR9 in Acute Graft-versus-Host Disease

Claudia Calcaterra, Lucia Sfondrini, Anna Rossini, Michele Sommariva, Cristiano Rumio, Sylvie Menard, and Andrea Balsari

Unique Receptor Repertoire in Mouse Uterine NK Cells

Hakim Yadi, Shannon Burke, Zofia Madeja, Myriam Hemberger, Ashley Moffett, and Francesco Colucci

Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E

Tracey A. Stephens, Enayat Nikoopour, Beverly J. Rider, Matilde Leon-Ponte, Thu A. Chau, Sebastian Mikolajczak, Pratibha Chaturvedi, Edwin Lee-Chan, Richard A. Flavell, S. M. Mansour Haeryfar, Joaquin Madrenas, and Bhagirath Singh

Immunosurveillance of Lung Melanoma Metastasis in EBI-3-Deficient Mice Mediated by CD8+ T Cells

Kerstin A. Sauer, Joachim H. Maxeiner, Roman Karwot, Petra Scholtes, Hans A. Lehr, Mark Birkenbach, Richard S. Blumberg, and Susetta Finotto

Cross-Linking of B7-H1 on EBV-Transformed B Cells Induces Apoptosis through Reactive Oxygen Species Production, JNK Signaling Activation, and FasL Expression

Yeong Seok Kim, Ga Bin Park, Hyun-Kyung Lee, Hyunkeun Song, In-Hak Choi, Wang Jae Lee, and Dae Young Hur

Human NK Cells Kill Resting but Not Activated Microglia via NKG2D- and NKp46-Mediated Recognition

Anna Lunemann, Jan D. Lunemann, Susanne Roberts, Brady Messmer, Rosa Barreira da Silva, Cedric S. Raine, and Christian Munz

CX3CR1+c-kit+ Bone Marrow Cells Give Rise to CD103+ and CD103- Dendritic Cells with Distinct Functional Properties

Maria-Luisa del Rio, Jose-Ignacio Rodriguez-Barbosa, Jasmin Bolter, Matthias Ballmaier, Oliver Dittrich-Breiholz, Michael Kracht, Steffen Jung, and Reinhold Forster

Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs

Tomoya Katakai, Hidenori Suto, Manabu Sugai, Hiroyuki Gonda, Atsushi Togawa, Sachiko Suematsu, Yukihiko Ebisuno, Koko Katagiri, Tatsuo Kinashi, and Akira Shimizu

Bacillus Calmette-Guerin Infection in the Central Nervous System Suppresses Experimental Autoimmune Encephalomyelitis and Th17 Responses in an IFN- Independent Manner

JangEun Lee, Emily K. Reinke, Alla L. Zozulya, Matyas Sandor, and Zsuzsanna Fabry

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Engineering Antibody Heavy Chain Complementarity Determining Region 3 to Create a Phage Display Fab Library Rich in Antibodies that Bind Charged Carbohydrates

Sonia Schoonbroodt, Mieke Steukers, Malini Viswanathan, Nicolas Frans, Marie Timmermans, Anita Wehnert, Minh Nguyen, Robert Charles Ladner, and Rene M. Hoet

Transcription Factor Gfi1 Restricts B Cell-Mediated Autoimmunity

Chozhavendan Rathinam, Hans Lassmann, Michael Mengel, and Christoph Klein

Automated Identification of Complementarity Determining Regions (CDRs) Reveals Peculiar Characteristics of CDRs and B Cell Epitopes

Yanay Ofran, Avner Schlessinger, and Burkhard Rost

n-3 Polyunsaturated Fatty Acids Suppress the Localization and Activation of Signaling Proteins at the Immunological Synapse in Murine CD4+ T Cells by Affecting Lipid Raft Formation

Wooki Kim, Yang-Yi Fan, Rola Barhoumi, Roger Smith, David N. McMurray, and Robert S. Chapkin

Loss of Protein Kinase C, Bcl10, or Malt1 Selectively Impairs Proliferation and NF-B Activation in the CD4+ T Cell Subset

Lara M. Kingeter and Brian C. Schaefer

Distinct CDR3 Conformations in TCR Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation

Lindsay L. Jones, Leremy A. Colf, Jennifer D. Stone, K. Christopher Garcia, and David M. Kranz

Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes

Sheila Chari and Susan Winandy

Endoplasmic Reticulum Aminopeptidase Associated with Ag Processing Regulates Quality of Processed Peptides Presented by MHC Class I Molecules

Takayuki Kanaseki and Nilabh Shastri

Hyaluronan Induces Cell Death in Activated T Cells through CD44

Brian Ruffell and Pauline Johnson

IMMUNOGENETICS

Impact of Protective IL-2 Allelic Variants on CD4+Foxp3+ Regulatory T Cell Function In Situ and Resistance to Autoimmune Diabetes in NOD Mice

Evridiki Sgouroudis, Alexandre Albanese, and Ciriaco A. Piccirillo

Polymorphic Sites Away From the Bw4 Epitope that Affect Interaction of Bw4+ HLA-B with KIR3DL1

Bharati Sanjanwala, Monia Draghi, Paul J. Norman, Lisbeth A. Guethlein, and Peter Parham

Complete Characterization of Killer Ig-Like Receptor (KIR) Haplotypes in Mauritian Cynomolgus Macaques: Novel Insights into Nonhuman Primate KIR Gene Content and Organization

Benjamin N. Bimber, Anna Moreland, Roger W. Wiseman, Austin L. Hughes, and David H. O'Connor

HOST DEFENSE

An Indispensable Role for the Chemokine Receptor CCR10 in IgA Antibody-Secreting Cell Accumulation

Olivier Morteau, Craig Gerard, Bao Lu, Sorina Ghiran, Miriam Rits, Yuko Fujiwara, Yuetching Law, Kathryn Distelhorst, Elizabeth M. Nielsen, Erica D. Hill, Raymond Kwan, Nicole H. Lazarus, Eugene C. Butcher, and Eric Wilson

A Novel Role of CD30L/CD30 Signaling by T-T Cell Interaction in Th1 Response against Mycobacterial Infection

Ce Tang, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Worawidh Wajjwalku, Eckhard R. Podack, and Yasunobu Yoshikai

Immune Evasion of Enterococcus faecalis by an Extracellular Gelatinase that Cleaves C3 and iC3b

Shin Yong Park, Yong Pyo Shin, Chong Han Kim, Ho Jin Park, Yeon Sun Seong, Byung Sam Kim, Sook Jae Seo, and In Hee Lee

Prior Immunization with Severe Acute Respiratory Syndrome (SARS)-Associated Coronavirus (SARS-CoV) Nucleocapsid Protein Causes Severe Pneumonia in Mice Infected with SARS-CoV

Fumihiko Yasui, Chieko Kai, Masahiro Kitabatake, Shingo Inoue, Misako Yoneda, Shoji Yokochi, Ryoichi Kase, Satoshi Sekiguchi, Kouichi Morita, Tsunekazu Hishima, Hidenori Suzuki, Katsuo Karamatsu, Yasuhiro Yasutomi, Hisatoshi Shida, Minoru Kidokoro, Kyosuke Mizuno, Kouji Matsushima, and Michinori Kohara

Tuberculosis Triggers a Tissue-Dependent Program of Differentiation and Acquisition of Effector Functions by Circulating Monocytes

Markus Skold and Samuel M. Behar

Design, Expression, and Processing of Epitomized Hepatitis C Virus-Encoded CTL Epitopes

Daniel Yerly, David Heckermann, Todd Allen, Todd J. Suscovich, Nebojsa Jojic, Carl Kadie, Werner J. Pichler, Andreas Cerny, and Christian Brander

Long-Term Immunity against Actual Poxviral HLA Ligands as Identified by Differential Stable Isotope Labeling

Verena S. Meyer, Wolfgang Kastenmuller, Georg Gasteiger, Mirita Franz-Wachtel, Tobias Lamkemeyer, Hans-Georg Rammensee, Stefan Stevanovic, Dagmar Sigurdardottir, and Ingo Drexler

CCL3-CCR5 Axis Regulates Intratumoral Accumulation of Leukocytes and Fibroblasts and Promotes Angiogenesis in Murine Lung Metastasis Process

Yu Wu, Ying-Yi Li, Kouji Matsushima, Tomohisa Baba, and Naofumi Mukaida

Ly49h-Deficient C57BL/6 Mice: A New Mouse Cytomegalovirus-Susceptible Model Remains Resistant to Unrelated Pathogens Controlled by the NK Gene Complex

Nassima Fodil-Cornu, Seung-Hwan Lee, Simon Belanger, Andrew P. Makrigiannis, Christine A. Biron, R. Mark Buller, and Silvia M. Vidal

Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells

Tzong-Shi Lu, Hava Karsenty Avraham, Seyha Seng, Souvenir D. Tachado, Henry Koziel, Alexandros Makriyannis, and Shalom Avraham

Prolonged Microglial Cell Activation and Lymphocyte Infiltration Following Experimental Herpes Encephalitis

Cristina P. Marques, Maxim C-J. Cheeran, Joseph M. Palmquist, Shuxian Hu, Stina L. Urban, and James R. Lokensgard

Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NFB Activation via the DNA-Dependent Activator of IFN Regulatory Factors

William J. Kaiser, Jason W. Upton, and Edward S. Mocarski

Hepatitis C Virus Immune Escape Via Exploitation of a Hole in the T Cell Repertoire

Matthias Wolfl, Alleluiah Rutebemberwa, Timothy Mosbruger, Qing Mao, Hong-mei Li, Dale Netski, Stuart C. Ray, Drew Pardoll, John Sidney, Alessandro Sette, Todd Allen, Thomas Kuntzen, Daniel G. Kavanagh, Jurgen Kuball, Philip D. Greenberg, and Andrea L. Cox

MyD88 Signaling Is Not Essential for Induction of Antigen-Specific B Cell Responses but Is Indispensable for Protection Against Streptococcus pneumoniae Infection following Oral Vaccination with Attenuated Salmonella Expressing PspA Antigen

Sung-Moo Park, Hyun-Jung Ko, Doo-Hee Shim, Jin-Young Yang, Yong-Ho Park, Roy Curtiss III, and Mi-Na Kweon

Expansion of Foxp3+ Regulatory T Cells in Mice Infected with the Filarial Parasite Brugia malayi

Henry J. McSorley, Yvonne M. Harcus, Janice Murray, Matthew D. Taylor, and Rick M. Maizels

The Level of Hepatitis B Virus Replication Is Not Affected by Protein ISG15 Modification but Is Reduced by Inhibition of UBP43 (USP18) Expression

Jung-Hwan Kim, Jiann-Kae Luo, and Dong-Er Zhang

INFLAMMATION

Functional Dichotomy of Dendritic Cells following Interaction with Leishmania braziliensis: Infected Cells Produce High Levels of TNF-, whereas Bystander Dendritic Cells Are Activated to Promote T Cell Responses

Lucas P. Carvalho, Edward J. Pearce, and Phillip Scott

Signaling through MyD88 Regulates Leukocyte Recruitment after Brain Injury

Alicia A. Babcock, Henrik Toft-Hansen, and Trevor Owens

Zinc Signals Are Essential for Lipopolysaccharide-Induced Signal Transduction in Monocytes

Hajo Haase, Julia L. Ober-Blobaum, Gabriela Engelhardt, Silke Hebel, Antje Heit, Holger Heine, and Lothar Rink

IL-4-Induced Selective Clearance of Oligomeric -Amyloid Peptide1-42 by Rat Primary Type 2 Microglia

Eisuke Shimizu, Kohichi Kawahara, Makoto Kajizono, Makoto Sawada, and Hitoshi Nakayama

12/15-Lipoxygenase Regulates the Inflammatory Response to Bacterial Products In Vivo

Vincent Dioszeghy, Marcela Rosas, Benjamin H. Maskrey, Chantal Colmont, Nicholas Topley, Pavlos Chaitidis, Hartmut Kuhn, Simon A. Jones, Philip R. Taylor, and Valerie B. O'Donnell

Human Plasmacytoid Dendritic Cells Interact with gp96 via CD91 and Regulate Inflammatory Responses

AnnaMaria De Filippo, Robert J. Binder, Chiara Camisaschi, Valeria Beretta, Flavio Arienti, Antonello Villa, Pamela Della Mina, Giorgio Parmiani, Licia Rivoltini, and Chiara Castelli

Differential Regulation of Chemokines by IL-17 in Colonic Epithelial Cells

Jimmy W. Lee, Ping Wang, Michael G. Kattah, Sawsan Youssef, Lawrence Steinman, Kathryn DeFea, and Daniel S. Straus

CCR5 Deficiency Aggravates Crescentic Glomerulonephritis in Mice

Jan-Eric Turner, Hans-Joachim Paust, Oliver M. Steinmetz, Anett Peters, Catherine Meyer-Schwesinger, Felix Heymann, Udo Helmchen, Susanne Fehr, Richard Horuk, Ulrich Wenzel, Christian Kurts, Hans-Willi Mittrucker, Rolf A. K. Stahl, and Ulf Panzer

Reversal of Thymic Stromal Lymphopoietin-Induced Airway Inflammation through Inhibition of Th2 Responses

Baohua Zhou, Mark B. Headley, Theingi Aye, Joel Tocker, Michael R. Comeau, and Steven F. Ziegler

Activation of an Immunoregulatory and Antiviral Gene Expression Program in Poly(I:C)-Transfected Human Neutrophils

Nicola Tamassia, Vincent Le Moigne, Marzia Rossato, Marta Donini, Stephen McCartney, Federica Calzetti, Marco Colonna, Flavia Bazzoni, and Marco A. Cassatella

Analysis of CD97 Expression and Manipulation: Antibody Treatment but Not Gene Targeting Curtails Granulocyte Migration

Henrike Veninga, Susann Becker, Robert M. Hoek, Manja Wobus, Elke Wandel, Jos van der Kaa, Martin van der Valk, Alex F. de Vos, Hannelore Haase, Bronwyn Owens, Tom van der Poll, Rene A.W. van Lier, J. Sjef Verbeek, Gabriela Aust, and Jorg Hamann

Up-Regulation of Vascular Endothelial Growth Factor-D Expression in Clear Cell Renal Cell Carcinoma by CD74: A Critical Role in Cancer Cell Tumorigenesis

Yu-Huei Liu, Chang-Yueh Lin, Wei-Chou Lin, Sai-Wen Tang, Ming-Kuen Lai, and Jung-Yaw Lin

CLINICAL IMMUNOLOGY

Carcinoembryonic Antigen-Specific but Not Antiviral CD4+ T Cell Immunity Is Impaired in Pancreatic Carcinoma Patients

Elena Tassi, Francesca Gavazzi, Luca Albarello, Vladimir Senyukov, Renato Longhi, Paolo Dellabona, Claudio Doglioni, Marco Braga, Valerio Di Carlo, and Maria Pia Protti

Sunlight Triggers Cutaneous Lupus through a CSF-1-dependent Mechanism in MRL-Faslpr Mice

Julia Menke, Mei-Yu Hsu, Katelyn T. Byrne, Julie A. Lucas, Whitney A. Rabacal, Byron P. Croker, Xiao-Hua Zong, E. Richard Stanley, and Vicki R. Kelley

Breaking of CD8+ T Cell Tolerance through In vivo Ligation of CD40 Results in inhibition of Chronic Graft-vs-Host Disease and Complete Donor Cell Engraftment

Juyang Kim, Keunhee Park, Hyun J. Kim, Jiyoung Kim, Hyun-A Kim, Daehee Jung, Hye J. Kim, Hye-Jeong Choi, Suck-Young Choi, Kwang W. Seo, Hong R. Cho, and Byungsuk Kwon

Strategic Nonmyeloablative Conditioning: CD154:CD40 Costimulatory Blockade at Primary Bone Marrow Transplantation Promotes Engraftment for Secondary Bone Marrow Transplantation after Engraftment Failure

Hong Xu, Yiming Huang, Paula M. Chilton, Lala-Rukh Hussain, Michael K. Tanner, Jun Yan, and Suzanne T. Ildstad

Characterization of the Antibody Response against NeuGcGM3 Ganglioside Elicited in Non-Small Cell Lung Cancer Patients Immunized with an Anti-Idiotype Antibody

Ana Maria Hernandez, Darien Toledo, Darel Martinez, Tania Grinan, Victor Brito, Amparo Macias, Sailyn Alfonso, Teresa Rondon, Eduardo Suarez, Ana Maria Vazquez, and Rolando Perez

Activation of Antigen-Specific Cytotoxic T Lymphocytes by 2-Microglobulin or TAP1 Gene Disruption and the Introduction of Recipient-Matched MHC Class I Gene in Allogeneic ES Cell-Derived Dendritic Cells

Yusuke Matsunaga, Daiki Fukuma, Shinya Hirata, Satoshi Fukushima, Miwa Haruta, Tokunori Ikeda, Izumi Negishi, Yasuharu Nishimura, and Satoru Senju

Immunization with a Mimotope of GD2 Ganglioside Induces CD8+ T Cells that Recognize Cell Adhesion Molecules on Tumor Cells

Andrzej Wierzbicki, Margaret Gil, Michael Ciesielski, Robert A. Fenstermaker, Yutaro Kaneko, Hanna Rokita, Joseph T. Lau, and Danuta Kozbor

Bone Marrow-Derived IFN-Producing Killer Dendritic Cells Account for the Tumoricidal Activity of Unpulsed Dendritic Cells

Nourredine Himoudi, Stephen Nabarro, Jo Buddle, Ayad Eddaoudi, Adrian J. Thrasher, and John Anderson

Crucial Role of Aspartic Acid at Position 265 in the CH2 Domain for Murine IgG2a and IgG2b Fc-Associated Effector Functions

Lucie Baudino, Yasuro Shinohara, Falk Nimmerjahn, Jun-Ichi Furukawa, Munehiro Nakata, Eduardo Martinez-Soria, Franz Petry, Jeffery V. Ravetch, Shin-Ichiro Nishimura, and Shozo Izu