The JI -- Table of Contents (183 [1])

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IN THIS ISSUE:

IN THIS ISSUE: J Immunol 2009 183: 1-2; doi:10.4049/jimmunol.0990044 [Full Text] [PDF] ImmunoCast

PILLARS OF IMMUNOLOGY:

The Original Intrathymic Progenitor from Which T Cells Originate: Juan Carlos Zúñiga-Pflücker
J Immunol 2009 183: 3-4; doi:10.4049/jimmunol.0990043 [Full Text] [PDF] [Original Pillars Article]

Pillars Article: Early T Lymphocytes. Differentiation In Vivo of Adult Intrathymic Precursor Cells. J. Exp. Med. 1985. 162: 802–822: B. J. Fowlkes, Linette Edison, Bonnie J. Mathieson, and Thomas M. Chused
J Immunol 2009 183: 5-25 [PDF]

CUTTING EDGE:

Cutting Edge: Cardiac Myosin Activates Innate Immune Responses through TLRs: Ping Zhang, Carol J. Cox, Kathy M. Alvarez, and Madeleine W. Cunningham
J Immunol 2009 183: 27-31; doi:10.4049/jimmunol.0800861 [Abstract] [Full Text] [PDF]

Cutting Edge: B and T Lymphocyte Attenuator Signaling on NKT Cells Inhibits Cytokine Release and Tissue Injury in Early Immune Responses: Mendy L. Miller, Yonglian Sun, and Yang-Xin Fu
J Immunol 2009 183: 32-36; doi:10.4049/jimmunol.0900690 [Abstract] [Full Text] [PDF] Data Supplement

Cutting Edge: Rapid and Efficient In Vivo Cytotoxicity by Cytotoxic T Cells Is Independent of Granzymes A and B: Matthias Regner, Lisa Pavlinovic, Aulikki Koskinen, Nicolie Young, Joseph A. Trapani, and Arno Müllbacher
J Immunol 2009 183: 37-40; doi:10.4049/jimmunol.0900466 [Abstract] [Full Text] [PDF]

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

CD44^high Memory CD8 T Cells Synergize with CpG DNA to Activate Dendritic Cell IL-12p70 Production: Kok Loon Wong, Li Fang Melissa Tang, Fei Chuin Lew, Hok Sum Kenneth Wong, Yen Leong Chua, Paul A. MacAry, and David M. Kemeny
J Immunol 2009 183: 41-50; doi:10.4049/jimmunol.0803473 [Abstract] [Full Text] [PDF]

IFN- ${gamma}$ Promotes Generation of IL-10 Secreting CD4⁺ T Cells that Suppress Generation of CD8 Responses in an Antigen-Experienced Host: Xiao Song Liu, Joanne Leerberg, Kelli MacDonald, Graham R. Leggatt, and Ian H. Frazer
J Immunol 2009 183: 51-58; doi:10.4049/jimmunol.0802047 [Abstract] [Full Text] [PDF]

Restricted Autoantigen Recognition Associated with Deletional and Adaptive Regulatory Mechanisms: John A. Gebe, Betty B. Yue, Kelly A. Unrath, Ben A. Falk, and Gerald T. Nepom
J Immunol 2009 183: 59-65; doi:10.4049/jimmunol.0804046 [Abstract] [Full Text] [PDF] Data Supplement

Aryl Hydrocarbon Receptor Activation Inhibits In Vitro Differentiation of Human Monocytes and Langerhans Dendritic Cells: Barbara Platzer, Susanne Richter, Doris Kneidinger, Darina Waltenberger, Maximilian Woisetschläger, and Herbert Strobl
J Immunol 2009 183: 66-74; doi:10.4049/jimmunol.0802997 [Abstract] [Full Text] [PDF]

T-bet-Deficient NOD Mice Are Protected from Diabetes Due to Defects in Both T Cell and Innate Immune System Function: Jonathan H. Esensten, Michael R. Lee, Laurie H. Glimcher, and Jeffrey A. Bluestone
J Immunol 2009 183: 75-82; doi:10.4049/jimmunol.0804154 [Abstract] [Full Text] [PDF] Data Supplement

Conservation of Structural and Functional Features in a Primordial CD80/86 Molecule from Rainbow Trout (Oncorhynchus mykiss), a Primitive Teleost Fish: Yong-An Zhang, Jun-ichi Hikima, Jun Li, Scott E. LaPatra, Yan-Ping Luo, and J. Oriol Sunyer
J Immunol 2009 183: 83-96; doi:10.4049/jimmunol.0900605 [Abstract] [Full Text] [PDF] Data Supplement

TGF-β Promotes Th17 Cell Development through Inhibition of SOCS3: Hongwei Qin, Lanfang Wang, Ting Feng, Charles O. Elson, Sandrine A. Niyongere, Sun Jung Lee, Stephanie L. Reynolds, Casey T. Weaver, Kevin Roarty, Rosa Serra, Etty N. Benveniste, and Yingzi Cong
J Immunol 2009 183: 97-105; doi:10.4049/jimmunol.0801986 [Abstract] [Full Text] [PDF]

The Expression and Function of the NKRP1 Receptor Family in C57BL/6 Mice: Jonathan G. Aust, Frances Gays, Katarzyna M. Mickiewicz, Ella Buchanan, and Colin G. Brooks
J Immunol 2009 183: 106-116; doi:10.4049/jimmunol.0804281 [Abstract] [Full Text] [PDF] Data Supplement

Modulating the Expression of IFN Regulatory Factor 8 Alters the Protumorigenic Behavior of CD11b⁺Gr-1⁺ Myeloid Cells: Trina J. Stewart, David J. Liewehr, Seth M. Steinberg, Kristy M. Greeneltch, and Scott I. Abrams
J Immunol 2009 183: 117-128; doi:10.4049/jimmunol.0804132 [Abstract] [Full Text] [PDF]

Increased Antigen Cross-Presentation but Impaired Cross-Priming after Activation of Peroxisome Proliferator-Activated Receptor ${gamma}$ Is Mediated by Up-Regulation of B7H1: Luisa Klotz, Stephanie Hucke, Dominik Thimm, Sabine Classen, Andrea Gaarz, Joachim Schultze, Frank Edenhofer, Christian Kurts, Thomas Klockgether, Andreas Limmer, Percy Knolle, and Sven Burgdorf
J Immunol 2009 183: 129-136; doi:10.4049/jimmunol.0804260 [Abstract] [Full Text] [PDF] Data Supplement

Chemotherapeutic Agents in Noncytotoxic Concentrations Increase Antigen Presentation by Dendritic Cells via an IL-12-Dependent Mechanism: Galina V. Shurin, Irina L. Tourkova, Ramon Kaneno, and Michael R. Shurin
J Immunol 2009 183: 137-144; doi:10.4049/jimmunol.0900734 [Abstract] [Full Text] [PDF]

Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4⁺CD25⁺ Foxp3⁺ T Regulatory Cells: Manuela Brenk, Marina Scheler, Susanne Koch, Jürgen Neumann, Osamu Takikawa, Georg Häcker, Thomas Bieber, and Dagmar von Bubnoff
J Immunol 2009 183: 145-154; doi:10.4049/jimmunol.0803277 [Abstract] [Full Text] [PDF] Data Supplement

STAT6 Activation Confers upon T Helper Cells Resistance to Suppression by Regulatory T Cells: Brendan B. L. Pillemer, Zengbiao Qi, Barbro Melgert, Timothy B. Oriss, Prabir Ray, and Anuradha Ray
J Immunol 2009 183: 155-163; doi:10.4049/jimmunol.0803733 [Abstract] [Full Text] [PDF]

The Effects of Cytokines on Suppression of Lymphocyte Proliferation by Dexamethasone: Tom J. Creed, Richard W. Lee, Paul V. Newcomb, Alexandra J. di Mambro, Madhuri Raju, and Colin M. Dayan
J Immunol 2009 183: 164-171; doi:10.4049/jimmunol.0801998 [Abstract] [Full Text] [PDF] Data Supplement

Role of CD44 in the Differentiation of Th1 and Th2 Cells: CD44-Deficiency Enhances the Development of Th2 Effectors in Response to Sheep RBC and Chicken Ovalbumin: Hongbing Guan, Prakash S. Nagarkatti, and Mitzi Nagarkatti
J Immunol 2009 183: 172-180; doi:10.4049/jimmunol.0802325 [Abstract] [Full Text] [PDF]

Vaccine-Induced CD8⁺ T Cell-Dependent Suppression of Airway Hyperresponsiveness and Inflammation: Katsuyuki Takeda, Steven W. Dow, Nobuaki Miyahara, Taku Kodama, Toshiyuki Koya, Christian Taube, Anthony Joetham, Jung-Won Park, Azzeddine Dakhama, Ross M. Kedl, and Erwin W. Gelfand
J Immunol 2009 183: 181-190; doi:10.4049/jimmunol.0803967 [Abstract] [Full Text] [PDF]

A Microbial Polysaccharide Reduces the Severity of Rheumatoid Arthritis by Influencing Th17 Differentiation and Proinflammatory Cytokines Production: Claudia Monari, Sara Bevilacqua, Miranda Piccioni, Eva Pericolini, Stefano Perito, Mario Calvitti, Francesco Bistoni, Thomas R. Kozel, and Anna Vecchiarelli
J Immunol 2009 183: 191-200; doi:10.4049/jimmunol.0804144 [Abstract] [Full Text] [PDF]

Cytokine-Dependent Modification of IL-12p70 and IL-23 Balance in Dendritic Cells by Ligand Activation of V ${alpha}$ 24 Invariant NKT Cells: Yasushi Uemura, Tian-Yi Liu, Yayoi Narita, Motoharu Suzuki, Ryusuke Nakatsuka, Tomoyuki Araki, Masahito Matsumoto, Leo Kei Iwai, Narumi Hirosawa, Yoshikazu Matsuoka, Mari Murakami, Takashi Kimura, Makoto Hase, Hirao Kohno, Yutaka Sasaki, Yasuko Ichihara, Osamu Ishihara, Hirosato Kikuchi, Yasushi Sakamoto, Shun-Chang Jiao, Satoru Senju, and Yoshiaki Sonoda
J Immunol 2009 183: 201-208; doi:10.4049/jimmunol.0900873 [Abstract] [Full Text] [PDF] Data Supplement

IFN- ${gamma}$ Attenuates Antigen-Induced Overall Immune Response in the Airway As a Th1-Type Immune Regulatory Cytokine: Kazuyuki Nakagome, Katsuhide Okunishi, Mitsuru Imamura, Hiroaki Harada, Taku Matsumoto, Ryoichi Tanaka, Jun-ichi Miyazaki, Kazuhiko Yamamoto, and Makoto Dohi
J Immunol 2009 183: 209-220; doi:10.4049/jimmunol.0802712 [Abstract] [Full Text] [PDF]

Sphingosine Kinase1 Is Pivotal for Fc ${epsilon}$ RI-Mediated Mast Cell Signaling and Functional Responses In Vitro and In Vivo: Peter N. Pushparaj, Jayapal Manikandan, Hwee Kee Tay, Shiau Chen H'ng, Srinivasan D. Kumar, Josef Pfeilschifter, Andrea Huwiler, and Alirio J. Melendez
J Immunol 2009 183: 221-227; doi:10.4049/jimmunol.0803430 [Abstract] [Full Text] [PDF]

SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo: D. James Haddon, Frann Antignano, Michael R. Hughes, Marie-Renée Blanchet, Lori Zbytnuik, Gerald Krystal, and Kelly M. McNagny
J Immunol 2009 183: 228-236; doi:10.4049/jimmunol.0900427 [Abstract] [Full Text] [PDF]

Type V Collagen-Induced Oral Tolerance Plus Low-Dose Cyclosporine Prevents Rejection of MHC Class I and II Incompatible Lung Allografts: Yoshito Yamada, Yasuo Sekine, Shigetoshi Yoshida, Kazuhiro Yasufuku, Irina Petrache, Heather L. Benson, David D. Brand, Ichiro Yoshino, and David S. Wilkes
J Immunol 2009 183: 237-245; doi:10.4049/jimmunol.0804028 [Abstract] [Full Text] [PDF]

Regulatory Properties of Copolymer I in Th17 Differentiation by Altering STAT3 Phosphorylation: Chunhua Chen, Xuebin Liu, Bing Wan, and Jingwu Z. Zhang
J Immunol 2009 183: 246-253; doi:10.4049/jimmunol.0900193 [Abstract] [Full Text] [PDF]

Production of Both IL-27 and IFN- ${gamma}$ after the Treatment with a Ligand for Invariant NK T Cells Is Responsible for the Suppression of Th2 Response and Allergic Inflammation in a Mouse Experimental Asthma Model: Hiroyuki Fujita, Annabelle Teng, Risa Nozawa, Yukiko Takamoto-Matsui, Haruka Katagiri-Matsumura, Zenro Ikezawa, and Yasuyuki Ishii
J Immunol 2009 183: 254-260; doi:10.4049/jimmunol.0800520 [Abstract] [Full Text] [PDF]

MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation: Lorraine A. O'Reilly, Elizabeth A. Kruse, Hamsa Puthalakath, Priscilla N. Kelly, Thomas Kaufmann, David C. S. Huang, and Andreas Strasser
J Immunol 2009 183: 261-269; doi:10.4049/jimmunol.0803853 [Abstract] [Full Text] [PDF] Data Supplement

Blocking CD27-CD70 Costimulatory Pathway Suppresses Experimental Colitis: Monika Manocha, Rietdijk Svend, Amale Laouar, Gongxian Liao, Atul Bhan, Jannine Borst, Cox Terhorst, and N. Manjunath
J Immunol 2009 183: 270-276; doi:10.4049/jimmunol.0802424 [Abstract] [Full Text] [PDF] Data Supplement

Gap Junctions at the Dendritic Cell-T Cell Interface Are Key Elements for Antigen-Dependent T Cell Activation: Raul Elgueta, Jaime A. Tobar, Kenji F. Shoji, Jaime De Calisto, Alexis M. Kalergis, Maria R. Bono, Mario Rosemblatt, and Juan C. Sáez
J Immunol 2009 183: 277-284; doi:10.4049/jimmunol.0801854 [Abstract] [Full Text] [PDF]

Altered Thymic Selection and Increased Autoimmunity Caused by Ectopic Expression of DRAK2 during T Cell Development: Martina Gatzka, Ryan H. Newton, and Craig M. Walsh
J Immunol 2009 183: 285-297; doi:10.4049/jimmunol.0803530 [Abstract] [Full Text] [PDF] Data Supplement

Early Life Exposure to Lipopolysaccharide Suppresses Experimental Autoimmune Encephalomyelitis by Promoting Tolerogenic Dendritic Cells and Regulatory T Cells: Kristofor K. Ellestad, Shigeki Tsutsui, Farshid Noorbakhsh, Kenneth G. Warren, V. Wee Yong, Quentin J. Pittman, and Christopher Power
J Immunol 2009 183: 298-309; doi:10.4049/jimmunol.0803576 [Abstract] [Full Text] [PDF] Data Supplement

Vav1 Regulates the Migration and Adhesion of Dendritic Cells: David R. Spurrell, Nancy A. Luckashenak, Derek C. Minney, Anna Chaplin, Joseph M. Penninger, Robert S. Liwski, James L. Clements, and Kenneth A. West
J Immunol 2009 183: 310-318; doi:10.4049/jimmunol.0802096 [Abstract] [Full Text] [PDF]

Clonotype Selection and Composition of Human CD8 T Cells Specific for Persistent Herpes Viruses Varies with Differentiation but Is Stable Over Time: Emanuela M. Iancu, Patricia Corthesy, Petra Baumgaertner, Estelle Devevre, Verena Voelter, Pedro Romero, Daniel E. Speiser, and Nathalie Rufer
J Immunol 2009 183: 319-331; doi:10.4049/jimmunol.0803647 [Abstract] [Full Text] [PDF]

The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells: William E. O'Gorman, Hans Dooms, Steve H. Thorne, Wilson F. Kuswanto, Erin F. Simonds, Peter O. Krutzik, Garry P. Nolan, and Abul K. Abbas
J Immunol 2009 183: 332-339; doi:10.4049/jimmunol.0900691 [Abstract] [Full Text] [PDF]

Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function: Malin Hedlund, Ann-Christin Stenqvist, Olga Nagaeva, Lennart Kjellberg, Marianne Wulff, Vladimir Baranov, and Lucia Mincheva-Nilsson
J Immunol 2009 183: 340-351; doi:10.4049/jimmunol.0803477 [Abstract] [Full Text] [PDF]

Notch Ligands Expressed by Follicular Dendritic Cells Protect Germinal Center B Cells from Apoptosis: Sun-Ok Yoon, Xin Zhang, Paul Berner, Bianca Blom, and Yong Sung Choi
J Immunol 2009 183: 352-358; doi:10.4049/jimmunol.0803183 [Abstract] [Full Text] [PDF] Data Supplement

Activated Integrin VLA-4 Localizes to the Lamellipodia and Mediates T Cell Migration on VCAM-1: Young-Min Hyun, Hung-Li Chung, James L. McGrath, Richard E. Waugh, and Minsoo Kim
J Immunol 2009 183: 359-369; doi:10.4049/jimmunol.0803388 [Abstract] [Full Text] [PDF] Data Supplement

Elimination of Immunodominant Epitopes from Multispecific DNA-Based Vaccines Allows Induction of CD8 T Cells That Have a Striking Antiviral Potential: Petra Riedl, Andreas Wieland, Kasper Lamberth, Soren Buus, Francois Lemonnier, Kurt Reifenberg, Jörg Reimann, and Reinhold Schirmbeck
J Immunol 2009 183: 370-380; doi:10.4049/jimmunol.0900505 [Abstract] [Full Text] [PDF]

IL-23 Promotes the Production of IL-17 by Antigen-Specific CD8 T Cells in the Absence of IL-12 and Type-I Interferons: Meredith M. Curtis, Sing Sing Way, and Christopher B. Wilson
J Immunol 2009 183: 381-387; doi:10.4049/jimmunol.0900939 [Abstract] [Full Text] [PDF]

Increased Intracellular, Cell Surface, and Secreted Inducible Heat Shock Protein 70 Responses Are Triggered during the Monocyte to Dendritic Cell (DC) Transition by Cytokines Independently of Heat Stress and Infection and May Positively Regulate DC Growth: Carla A. Martin, Danielle L. Kurkowski, Alisa M. Valentino, and Frances Santiago-Schwarz
J Immunol 2009 183: 388-399; doi:10.4049/jimmunol.0802688 [Abstract] [Full Text] [PDF] Data Supplement

CD11c⁺CD8 ${alpha}$ ⁺ Dendritic Cells Promote Protective Immunity to Respiratory Infection with Bordetella pertussis: Pádraic J. Dunne, Barry Moran, Robert C. Cummins, and Kingston H. G. Mills
J Immunol 2009 183: 400-410; doi:10.4049/jimmunol.0900169 [Abstract] [Full Text] [PDF]

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Neutrophil Elastase Represses IL-8/CXCL8 Synthesis in Human Airway Smooth Muscle Cells through Induction of NF- ${kappa}$ B Repressing Factor: Shu-Chuan Ho, Kang-Yun Lee, Yao-Fei Chan, Lu-Wei Kuo, Kazuhiro Ito, Ian M. Adcock, Bing-Chang Chen, Joen-Rong Sheu, Chien-Huang Lin, and Han-Pin Kuo
J Immunol 2009 183: 411-420; doi:10.4049/jimmunol.0803729 [Abstract] [Full Text] [PDF]

Structural Basis for Proteolytic Specificity of the Human Apoptosis-Inducing Granzyme M: Lianfeng Wu, Li Wang, Guoqiang Hua, Kan Liu, Xuan Yang, Yujia Zhai, Mark Bartlam, Fei Sun, and Zusen Fan
J Immunol 2009 183: 421-429; doi:10.4049/jimmunol.0803088 [Abstract] [Full Text] [PDF]

Structural Bases for the Affinity-Driven Selection of a Public TCR against a Dominant Human Cytomegalovirus Epitope: Stéphanie Gras, Xavier Saulquin, Jean-Baptiste Reiser, Emilie Debeaupuis, Klara Echasserieau, Adrien Kissenpfennig, François Legoux, Anne Chouquet, Madalen Le Gorrec, Paul Machillot, Bérangère Neveu, Nicole Thielens, Bernard Malissen, Marc Bonneville, and Dominique Housset
J Immunol 2009 183: 430-437; doi:10.4049/jimmunol.0900556 [Abstract] [Full Text] [PDF] Data Supplement

The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells: Leon L. Su, Hideyuki Iwai, Jack T. Lin, and C. Garrison Fathman
J Immunol 2009 183: 438-444; doi:10.4049/jimmunol.0900204 [Abstract] [Full Text] [PDF]

The Coding ECP 434(G>C) Gene Polymorphism Determines the Cytotoxicity of ECP but Has Minor Effects on Fibroblast-Mediated Gel Contraction and No Effect on RNase Activity: Jenny Rubin, Ulrika Zagai, Kristin Blom, Agneta Trulson, Åke Engström, and Per Venge
J Immunol 2009 183: 445-451; doi:10.4049/jimmunol.0803912 [Abstract] [Full Text] [PDF]

IMMUNOGENETICS:

Antibodies in a Heavy Chain Knock-In Mouse Exhibit Characteristics of Early Heavy Chain Rearrangement: Lenka Yunk, Wenzhao Meng, Philip L. Cohen, Robert A. Eisenberg, and Eline T. Luning Prak
J Immunol 2009 183: 452-461; doi:10.4049/jimmunol.0804060 [Abstract] [Full Text] [PDF] Data Supplement

Identification of a Major Susceptibility Locus for Lethal Graft-versus-Host Disease in MHC-Matched Mice: Thai M. Cao, Laura C. Lazzeroni, Schickwann Tsai, Wendy W. Pang, Amy Kao, Nicola J. Camp, Alun Thomas, and Judith A. Shizuru
J Immunol 2009 183: 462-469; doi:10.4049/jimmunol.0900454 [Abstract] [Full Text] [PDF] Data Supplement

HOST DEFENSE:

Immunization with the DNA-Encoding N-Terminal Domain of Proteophosphoglycan of Leishmania donovani Generates Th1-Type Immunoprotective Response against Experimental Visceral Leishmaniasis: Mukesh Samant, Reema Gupta, Shraddha Kumari, Pragya Misra, Prashant Khare, Pramod Kumar Kushawaha, Amogh Anant Sahasrabuddhe, and Anuradha Dube
J Immunol 2009 183: 470-479; doi:10.4049/jimmunol.0900265 [Abstract] [Full Text] [PDF]

Multivalent Binding of Carbohydrates by the Human ${alpha}$ -Defensin, HD5: Robert I. Lehrer, Grace Jung, Piotr Ruchala, Sabine Andre, Hans J. Gabius, and Wuyuan Lu
J Immunol 2009 183: 480-490; doi:10.4049/jimmunol.0900244 [Abstract] [Full Text] [PDF]

Downstream Signals for MyD88-Mediated Phagocytosis of Borrelia burgdorferi Can Be Initiated by TRIF and Are Dependent on PI3K: Ok S. Shin, Lloyd S. Miller, Robert L. Modlin, Shizuo Akira, Satoshi Uematsu, and Linden T. Hu
J Immunol 2009 183: 491-498; doi:10.4049/jimmunol.0900724 [Abstract] [Full Text] [PDF]

The Cannabinoid Receptor 2 Is Critical for the Host Response to Sepsis: Johannes Tschöp, Kevin R. Kasten, Ruben Nogueiras, Holly S. Goetzman, Cynthia M. Cave, Lisa G. England, Jonathan Dattilo, Alex B. Lentsch, Matthias H. Tschöp, and Charles C. Caldwell
J Immunol 2009 183: 499-505; doi:10.4049/jimmunol.0900203 [Abstract] [Full Text] [PDF] Data Supplement

Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering: Anne-Catherine Raby, Emmanuel Le Bouder, Chantal Colmont, James Davies, Peter Richards, Barbara Coles, Christopher H. George, Simon A. Jones, Paul Brennan, Nicholas Topley, and Mario O. Labéta
J Immunol 2009 183: 506-517; doi:10.4049/jimmunol.0802909 [Abstract] [Full Text] [PDF]

Generation of Protective T Cell-Independent Antiviral Antibody Responses in SCID Mice Reconstituted with Follicular or Marginal Zone B Cells: Heath M. Guay, Rabinarayan Mishra, Robert L. Garcea, Raymond M. Welsh, and Eva Szomolanyi-Tsuda
J Immunol 2009 183: 518-523; doi:10.4049/jimmunol.0900068 [Abstract] [Full Text] [PDF]

Follicular Dendritic Cells Activate HIV-1 Replication in Monocytes/Macrophages through a Juxtacrine Mechanism Mediated by P-Selectin Glycoprotein Ligand 1: Kenji Ohba, Akihide Ryo, Md. Zahidunnabi Dewan, Mayuko Nishi, Toshio Naito, Xiaohua Qi, Yoshio Inagaki, Yoji Nagashima, Yuetsu Tanaka, Takashi Okamoto, Kazuo Terashima, and Naoki Yamamoto
J Immunol 2009 183: 524-532; doi:10.4049/jimmunol.0900371 [Abstract] [Full Text] [PDF] Data Supplement

In Vivo Lipopolysaccharide Exposure of Human Blood Leukocytes Induces Cross-Tolerance to Multiple TLR Ligands: Alex F. de Vos, Jennie M. Pater, Petra S. van den Pangaart, Martijn D. de Kruif, Cornelis van 't Veer, and Tom van der Poll
J Immunol 2009 183: 533-542; doi:10.4049/jimmunol.0802189 [Abstract] [Full Text] [PDF]

LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline: Gudmundur Bergsson, Emer P. Reeves, Paul McNally, Sanjay H. Chotirmall, Catherine M. Greene, Peter Greally, Philip Murphy, Shane J. O'Neill, and Noel G. McElvaney
J Immunol 2009 183: 543-551; doi:10.4049/jimmunol.0803959 [Abstract] [Full Text] [PDF]

INFLAMMATION:

Cholinergic Neural Signals to the Spleen Down-Regulate Leukocyte Trafficking via CD11b: Jared M. Huston, Mauricio Rosas-Ballina, Xiangying Xue, Oonagh Dowling, Kanta Ochani, Mahendar Ochani, Michael M. Yeboah, Prodyot K. Chatterjee, Kevin J. Tracey, and Christine N. Metz
J Immunol 2009 183: 552-559; doi:10.4049/jimmunol.0802684 [Abstract] [Full Text] [PDF] Data Supplement

Major Role of ${gamma}$ ${delta}$ T Cells in the Generation of IL-17⁺ Uveitogenic T Cells: Yan Cui, Hui Shao, Chen Lan, Hong Nian, Rebecca L. O'Brien, Willi K. Born, Henry J. Kaplan, and Deming Sun
J Immunol 2009 183: 560-567; doi:10.4049/jimmunol.0900241 [Abstract] [Full Text] [PDF]

IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease: Kirk A. Staschke, Sucai Dong, Joy Saha, Jingyong Zhao, Nathan A. Brooks, Deena L. Hepburn, Jinqi Xia, Muhammet F. Gulen, Zizhen Kang, Cengiz Z. Altuntas, Vincent K. Tuohy, Raymond Gilmour, Xiaoxia Li, and Songqing Na
J Immunol 2009 183: 568-577; doi:10.4049/jimmunol.0802361 [Abstract] [Full Text] [PDF]

Differential Regulation of P2X₇ Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells: Shiyuan Hong, Nicole Schwarz, Anette Brass, Michel Seman, Friedrich Haag, Friedrich Koch-Nolte, William P. Schilling, and George R. Dubyak
J Immunol 2009 183: 578-592; doi:10.4049/jimmunol.0900120 [Abstract] [Full Text] [PDF]

Pleiotropic Roles of S100A12 in Coronary Atherosclerotic Plaque Formation and Rupture: Jesse Goyette, Wei Xing Yan, Eric Yamen, Yuen Ming Chung, Su Yin Lim, Kenneth Hsu, Farid Rahimi, Nick Di Girolamo, Changjie Song, Wendy Jessup, Maaike Kockx, Yuri V. Bobryshev, S. Ben Freedman, and Carolyn L. Geczy
J Immunol 2009 183: 593-603; doi:10.4049/jimmunol.0900373 [Abstract] [Full Text] [PDF]

Pulmonary Eosinophils and Their Role in Immunopathologic Responses to Formalin-Inactivated Pneumonia Virus of Mice: Caroline M. Percopo, Zhijun Qiu, Simon Phipps, Paul S. Foster, Joseph B. Domachowske, and Helene F. Rosenberg
J Immunol 2009 183: 604-612; doi:10.4049/jimmunol.0802270 [Abstract] [Full Text] [PDF] Data Supplement

IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis: Erin E. McCandless, Matthew Budde, Jason R. Lees, Denise Dorsey, Eric Lyng, and Robyn S. Klein
J Immunol 2009 183: 613-620; doi:10.4049/jimmunol.0802258 [Abstract] [Full Text] [PDF]

The Presumed Hyporesponsive Behavior of Rheumatoid Arthritis T Lymphocytes Can Be Attributed to Spontaneous Ex Vivo Apoptosis rather than Defects in T Cell Receptor Signaling: Joana R. F. Abreu, Aleksander M. Grabiec, Sarah Krausz, René Spijker, Tomasz Burakowski, Wlodzimierz Maslinski, Eric Eldering, Paul P. Tak, and Kris A. Reedquist
J Immunol 2009 183: 621-630; doi:10.4049/jimmunol.0803278 [Abstract] [Full Text] [PDF]

Aberrant Tissue Localization of Fungus-Specific CD4⁺ T Cells in IL-10-Deficient Mice: Amariliz Rivera, Nichole Collins, Matthias T. Stephan, Lauren Lipuma, Ingrid Leiner, and Eric G. Pamer
J Immunol 2009 183: 631-641; doi:10.4049/jimmunol.0900396 [Abstract] [Full Text] [PDF] Data Supplement

T-bet Knockout Prevents Helicobacter felis-Induced Gastric Cancer: Calin Stoicov, Xueli Fan, Jian Hua Liu, Glennice Bowen, Mark Whary, Evelyn Kurt-Jones, and JeanMarie Houghton
J Immunol 2009 183: 642-649; doi:10.4049/jimmunol.0900511 [Abstract] [Full Text] [PDF]

Fusion Loop Peptide of the West Nile Virus Envelope Protein Is Essential for Pathogenesis and Is Recognized by a Therapeutic Cross-Reactive Human Monoclonal Antibody: Hameeda Sultana, Harald G. Foellmer, Girish Neelakanta, Theodore Oliphant, Michael Engle, Michel Ledizet, Manoj N. Krishnan, Nathalie Bonafé, Karen G. Anthony, Wayne A. Marasco, Paul Kaplan, Ruth R. Montgomery, Michael S. Diamond, Raymond A. Koski, and Erol Fikrig
J Immunol 2009 183: 650-660; doi:10.4049/jimmunol.0900093 [Abstract] [Full Text] [PDF] Data Supplement

Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS: Huanyu Dou, Cassi B. Grotepas, JoEllyn M. McMillan, Christopher J. Destache, Mahesh Chaubal, Jane Werling, James Kipp, Barrett Rabinow, and Howard E. Gendelman
J Immunol 2009 183: 661-669; doi:10.4049/jimmunol.0900274 [Abstract] [Full Text] [PDF] Data Supplement

Lack of MyD88 Protects the Immunodeficient Host Against Fatal Lung Inflammation Triggered by the Opportunistic Bacteria Burkholderia cenocepacia: Grasiella M. de C. Ventura, Viviane Balloy, Reuben Ramphal, Huot Khun, Michel Huerre, Bernhard Ryffel, Maria-Cristina M. Plotkowski, Michel Chignard, and Mustapha Si-Tahar
J Immunol 2009 183: 670-676; doi:10.4049/jimmunol.0801497 [Abstract] [Full Text] [PDF] Data Supplement

CLINICAL IMMUNOLOGY:

Evidence for the Specificity for Platelet HPA-1a Alloepitope and the Presenting HLA-DR52a of Diverse Antigen-Specific Helper T Cell Clones from Alloimmunized Mothers: Rachel Rayment, Taco W. Kooij, Wei Zhang, Christian Siebold, Mike F. Murphy, Dave Allen, Nick Willcox, and David J. Roberts
J Immunol 2009 183: 677-686; doi:10.4049/jimmunol.0801473 [Abstract] [Full Text] [PDF]

Expression of IL-24, an Activator of the JAK1/STAT3/SOCS3 Cascade, Is Enhanced in Inflammatory Bowel Disease: Akira Andoh, Makoto Shioya, Atsushi Nishida, Shigeki Bamba, Tomoyuki Tsujikawa, Shokei Kim-Mitsuyama, and Yoshihide Fujiyama
J Immunol 2009 183: 687-695; doi:10.4049/jimmunol.0804169 [Abstract] [Full Text] [PDF]

Selective Reduction of Graft-versus-Host Disease-Mediating Human T Cells by Ex Vivo Treatment with Soluble Fas Ligand: Osnat Bohana-Kashtan, Sebastien Morisot, Richard Hildreth, Cory Brayton, Hyam I. Levitsky, and Curt I. Civin
J Immunol 2009 183: 696-705; doi:10.4049/jimmunol.0800561 [Abstract] [Full Text] [PDF] Data Supplement

Vaccine-Induced, Simian Immunodeficiency Virus-Specific CD8⁺ T Cells Reduce Virus Replication but Do Not Protect from Simian Immunodeficiency Virus Disease Progression: Jessica C. Engram, Richard M. Dunham, George Makedonas, Thomas H. Vanderford, Beth Sumpter, Nichole R. Klatt, Sarah J. Ratcliffe, Seema Garg, Mirko Paiardini, Monica McQuoid, John D. Altman, Silvija I. Staprans, Michael R. Betts, David A. Garber, Mark B. Feinberg, and Guido Silvestri
J Immunol 2009 183: 706-717; doi:10.4049/jimmunol.0803746 [Abstract] [Full Text] [PDF]

Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity: Alexandre S. Almeida, Patrícia M. Lago, Neio Boechat, Richard C. Huard, Luiz C. O. Lazzarini, Adalberto R. Santos, Marcelo Nociari, Hongxia Zhu, Beatriz M. Perez-Sweeney, Heejung Bang, Quanhong Ni, Jie Huang, Andrea L. Gibson, Vera C. Flores, Lorena R. Pecanha, Afrânio L. Kritski, José R. Lapa e Silva, and John L. Ho
J Immunol 2009 183: 718-731; doi:10.4049/jimmunol.0801212 [Abstract] [Full Text] [PDF] Data Supplement

A Novel Recombinant Fusion Protein Encoding a 20-Amino Acid Residue of the Third Extracellular (E3) Domain of CCR2 Neutralizes the Biological Activity of CCL2: Liat Izhak, Gizi Wildbaum, Yaniv Zohar, Rachel Anunu, Leah Klapper, Adi Elkeles, Jane Seagal, Eitan Yefenof, Michal Ayalon-Soffer, and Nathan Karin
J Immunol 2009 183: 732-739; doi:10.4049/jimmunol.0802746 [Abstract] [Full Text] [PDF]

Coexpression of IL-18 Strongly Attenuates IL-12-Induced Systemic Toxicity through a Rapid Induction of IL-10 without Affecting its Antitumor Capacity: Maria Cecilia Rodriguez-Galan, Della Reynolds, Silvia G. Correa, Pablo Iribarren, Morihiro Watanabe, and Howard A. Young
J Immunol 2009 183: 740-748; doi:10.4049/jimmunol.0804166 [Abstract] [Full Text] [PDF]

Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX: Andrew W. Pawluczkowycz, Frank J. Beurskens, Paul V. Beum, Margaret A. Lindorfer, Jan G. J. van de Winkel, Paul W. H. I. Parren, and Ronald P. Taylor
J Immunol 2009 183: 749-758; doi:10.4049/jimmunol.0900632 [Abstract] [Full Text] [PDF]

Systemic Reduction of Functionally Suppressive CD4^dimCD25^highFoxp3⁺ Tregs in Human Second Trimester Pregnancy Is Induced by Progesterone and 17β-Estradiol: Jenny Mjösberg, Judit Svensson, Emma Johansson, Lotta Hellström, Rosaura Casas, Maria C. Jenmalm, Roland Boij, Leif Matthiesen, Jan-Ingvar Jönsson, Göran Berg, and Jan Ernerudh
J Immunol 2009 183: 759-769; doi:10.4049/jimmunol.0803654 [Abstract] [Full Text] [PDF]

CORRECTIONS:

The cyclic AMP response element modulator ${alpha}$ suppresses CD86 expression and APC function: M. Ahlmann, G. Varga, K. Sturm, R. Lippe, K. Benedyk, D. Viemann, T. Scholzen, J. Ehrchen, F. U. Müller, M. Seidl, M. Matus, G. C. Tsokos, J. Roth, and K. Tenbrock
J Immunol 2009 183: 770; doi:10.4049/jimmunol.0990045 [Full Text] [PDF]