IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2009 183: 1501-1502; doi:10.4049/jimmunol.0990050 [Full Text] [PDF] ImmunoCast  

PILLARS OF IMMUNOLOGY:

Conveying the Message: Identification of Ig- and Ig-β as Components of the B Cell Receptor Complex

James Hagman
J Immunol 2009 183: 1503-1504; doi:10.4049/jimmunol.0990055 [Full Text] [PDF] [Original Pillars Article]  

Pillars Article: Molecular components of the B-cell antigen receptor complex of the IgM class. 1990. Nature 243: 760–762

Joachim Hombach, Takeshi Tsubata, Lise Leclercq, Heike Stappert, and Michael Reth
J Immunol 2009 183: 1505-1507 [PDF]  

CUTTING EDGE:

Cutting Edge: SWI/SNF Mediates Antisense Igh Transcription and Locus-Wide Accessibility in B Cell Precursors

Oleg A. Osipovich, Ramesh Subrahmanyam, Steven Pierce, Ranjan Sen, and Eugene M. Oltz
J Immunol 2009 183: 1509-1513. Published online July 13, 2009; doi:10.4049/jimmunol.0900896 [Abstract] [Full Text] [PDF]  

Cutting Edge: B220⁺CCR9^– Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells

Elodie Segura, June Wong, and José A. Villadangos
J Immunol 2009 183: 1514-1517. Published online July 1, 2009; doi:10.4049/jimmunol.0901524 [Abstract] [Full Text] [PDF]  

Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus

Noriko Iikuni, Elaine V. Lourenço, Bevra H. Hahn, and Antonio La Cava
J Immunol 2009 183: 1518-1522. Published online July 1, 2009; doi:10.4049/jimmunol.0901163 [Abstract] [Full Text] [PDF]  

Cutting Edge: Limiting MHC Class II Expression to Dendritic Cells Alters the Ability to Develop Th2- Dependent Allergic Airway Inflammation

Naiqian Niu, Terri Laufer, Robert J. Homer, and Lauren Cohn
J Immunol 2009 183: 1523-1527. Published online July 13, 2009; doi:10.4049/jimmunol.0901349 [Abstract] [Full Text] [PDF] Data Supplement  

Cutting Edge: Necrosis Activates the NLRP3 Inflammasome

Hanfen Li, Aditya Ambade, and Fabio Re
J Immunol 2009 183: 1528-1532. Published online July 13, 2009; doi:10.4049/jimmunol.0901080 [Abstract] [Full Text] [PDF] Data Supplement  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Expression of Diabetes-Associated Genes by Dendritic Cells and CD4 T Cells Drives the Loss of Tolerance in Nonobese Diabetic Mice

Emma E. Hamilton-Williams, Xavier Martinez, Jan Clark, Sarah Howlett, Kara M. Hunter, Daniel B. Rainbow, Li Wen, Mark J. Shlomchik, Jonathan D. Katz, Georg F. Beilhack, Linda S. Wicker, and Linda A. Sherman
J Immunol 2009 183: 1533-1541. Published online July 10, 2009; doi:10.4049/jimmunol.0900428 [Abstract] [Full Text] [PDF]  

Diminished Intracellular Invariant Chain Expression after Vaccinia Virus Infection

Nan Wang, Ekkehard Weber, and Janice S. Blum
J Immunol 2009 183: 1542-1550. Published online July 10, 2009; doi:10.4049/jimmunol.0802741 [Abstract] [Full Text] [PDF]  

Parameters Underlying Distinct T Cell-Dependent Polysaccharide-Specific IgG Responses to an Intact Gram-Positive Bacterium versus a Soluble Conjugate Vaccine

Jesus Colino, Gouri Chattopadhyay, Goutam Sen, Quanyi Chen, Andrew Lees, David H. Canaday, Anatoly Rubtsov, Raul Torres, and Clifford M. Snapper
J Immunol 2009 183: 1551-1559. Published online July 1, 2009; doi:10.4049/jimmunol.0900238 [Abstract] [Full Text] [PDF]  

Expression of a CD200 Transgene Is Necessary for Induction but Not Maintenance of Tolerance to Cardiac and Skin Allografts

Reginald M. Gorczynski, Zhiqi Chen, William He, Ismat Khatri, Yang Sun, Kai Yu, and Ivo Boudakov
J Immunol 2009 183: 1560-1568. Published online July 10, 2009; doi:10.4049/jimmunol.0900200 [Abstract] [Full Text] [PDF]  

Murine B Cell Response to TLR7 Ligands Depends on an IFN-β Feedback Loop

Nathaniel M. Green, Amy Laws, Kerstin Kiefer, Liliana Busconi, You-Me Kim, Melanie M. Brinkmann, Erin Hodges Trail, Kei Yasuda, Sean R. Christensen, Mark J. Shlomchik, Stefanie Vogel, John H. Connor, Hidde Ploegh, Dan Eilat, Ian R. Rifkin, Jean Maguire van Seventer, and Ann Marshak-Rothstein
J Immunol 2009 183: 1569-1576. Published online July 8, 2009; doi:10.4049/jimmunol.0803899 [Abstract] [Full Text] [PDF]  

Infection with a Helminth Parasite Attenuates Autoimmunity through TGF-β-Mediated Suppression of Th17 and Th1 Responses

Kevin P. Walsh, Miriam T. Brady, Conor M. Finlay, Louis Boon, and Kingston H. G. Mills
J Immunol 2009 183: 1577-1586. Published online July 8, 2009; doi:10.4049/jimmunol.0803803 [Abstract] [Full Text] [PDF]  

Processing of Two Latent Membrane Protein 1 MHC Class I Epitopes Requires Tripeptidyl Peptidase II Involvement

Jan Diekmann, Eleni Adamopoulou, Olaf Beck, Georg Rauser, Sarah Lurati, Stefan Tenzer, Hermann Einsele, Hans-Georg Rammensee, Hansjörg Schild, and Max S. Topp
J Immunol 2009 183: 1587-1597. Published online July 8, 2009; doi:10.4049/jimmunol.0803441 [Abstract] [Full Text] [PDF]  

IFN Regulatory Factor 4 Regulates the Expression of a Subset of Th2 Cytokines

Ayele-Nati N. Ahyi, Hua-Chen Chang, Alexander L. Dent, Stephen L. Nutt, and Mark H. Kaplan
J Immunol 2009 183: 1598-1606. Published online July 10, 2009; doi:10.4049/jimmunol.0803302 [Abstract] [Full Text] [PDF]  

An Atopy-Associated Polymorphism in the Ectodomain of the IL-4R Chain (V50) Regulates the Persistence of STAT6 Phosphorylation

Andrew Q. Ford, Nicola M. Heller, Linda Stephenson, Mark R. Boothby, and Achsah D. Keegan
J Immunol 2009 183: 1607-1616. Published online July 10, 2009; doi:10.4049/jimmunol.0803266 [Abstract] [Full Text] [PDF]  

MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge

Guoku Hu, Rui Zhou, Jun Liu, Ai-Yu Gong, Alex N. Eischeid, Jared W. Dittman, and Xian-Ming Chen
J Immunol 2009 183: 1617-1624. Published online July 10, 2009; doi:10.4049/jimmunol.0804362 [Abstract] [Full Text] [PDF]  

Anti-CD40 Monoclonal Antibody Synergizes with CTLA4-Ig in Promoting Long-Term Graft Survival in Murine Models of Transplantation

Christopher R. Gilson, Zvonimir Milas, Shivaprakash Gangappa, Diane Hollenbaugh, Thomas C. Pearson, Mandy L. Ford, and Christian P. Larsen
J Immunol 2009 183: 1625-1635. Published online July 10, 2009; doi:10.4049/jimmunol.0900339 [Abstract] [Full Text] [PDF]  

Tissue-Specific Abundance of Regulatory T Cells Correlates with CD8⁺ T Cell Dysfunction and Chronic Retrovirus Loads

Lara Myers, Ronald J. Messer, Aaron B. Carmody, and Kim J. Hasenkrug
J Immunol 2009 183: 1636-1643. Published online July 8, 2009; doi:10.4049/jimmunol.0900350 [Abstract] [Full Text] [PDF]  

Incorporation of NKT Cell-Activating Glycolipids Enhances Immunogenicity and Vaccine Efficacy of Mycobacterium bovis Bacillus Calmette-Guérin

Manjunatha M. Venkataswamy, Andres Baena, Michael F. Goldberg, Gabriel Bricard, Jin S. Im, John Chan, Faye Reddington, Gurdyal S. Besra, William R. Jacobs, Jr., and Steven A. Porcelli
J Immunol 2009 183: 1644-1656; doi:10.4049/jimmunol.0900858 [Abstract] [Full Text] [PDF] Data Supplement  

A Central Role for Transcription Factor C/EBP-β in Regulating CD1d Gene Expression in Human Keratinocytes

Hashmat Sikder, Yuming Zhao, Anna Balato, Andre Chapoval, Rita Fishelevich, Padmaja Gade, Ishwar S. Singh, Dhananjaya V. Kalvakolanu, Peter F. Johnson, and Anthony A. Gaspari
J Immunol 2009 183: 1657-1666. Published online July 10, 2009; doi:10.4049/jimmunol.0900057 [Abstract] [Full Text] [PDF]  

Fas Apoptosis Inhibitory Molecule Enhances CD40 Signaling in B Cells and Augments the Plasma Cell Compartment

Hiroaki Kaku and Thomas L. Rothstein
J Immunol 2009 183: 1667-1674. Published online July 10, 2009; doi:10.4049/jimmunol.0900056 [Abstract] [Full Text] [PDF]  

Uncoordinated 119 Protein Controls Trafficking of Lck via the Rab11 Endosome and Is Critical for Immunological Synapse Formation

Magdalena M. Gorska, Qiaoling Liang, Zunayet Karim, and Rafeul Alam
J Immunol 2009 183: 1675-1684. Published online July 10, 2009; doi:10.4049/jimmunol.0900792 [Abstract] [Full Text] [PDF] Data Supplement  

Palmitoylation-Dependent Plasma Membrane Transport but Lipid Raft-Independent Signaling by Linker for Activation of T Cells

Matthias Hundt, Yohsuke Harada, Lauren De Giorgio, Natsuko Tanimura, Weiguo Zhang, and Amnon Altman
J Immunol 2009 183: 1685-1694. Published online July 10, 2009; doi:10.4049/jimmunol.0803921 [Abstract] [Full Text] [PDF]  

Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

Pujya Agarwal, Arvind Raghavan, Sarada L. Nandiwada, Julie M. Curtsinger, Paul R. Bohjanen, Daniel L. Mueller, and Matthew F. Mescher
J Immunol 2009 183: 1695-1704. Published online July 10, 2009; doi:10.4049/jimmunol.0900592 [Abstract] [Full Text] [PDF] Data Supplement  

Spontaneous Autoimmunity Sufficiently Potent to Induce Diabetes Mellitus Is Insufficient to Protect against Insulinoma

Kelley Zwicker, Christa Chatten, Kathy Gratton, Doug Demetrick, Pau Serra, Afshin Shameli, Pere Santamaria, and Oliver F. Bathe
J Immunol 2009 183: 1705-1714. Published online July 1, 2009; doi:10.4049/jimmunol.0800902 [Abstract] [Full Text] [PDF] Data Supplement  

Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease

Corinna F. Brereton, Caroline E. Sutton, Stephen J. Lalor, Ed C. Lavelle, and Kingston H. G. Mills
J Immunol 2009 183: 1715-1723. Published online July 1, 2009; doi:10.4049/jimmunol.0803851 [Abstract] [Full Text] [PDF]  

Human CD14⁺ Macrophages in Intestinal Lamina Propria Exhibit Potent Antigen-Presenting Ability

Nobuhiko Kamada, Tadakazu Hisamatsu, Haruki Honda, Taku Kobayashi, Hiroshi Chinen, Mina Tokutake Kitazume, Tetsuro Takayama, Susumu Okamoto, Kazutaka Koganei, Akira Sugita, Takanori Kanai, and Toshifumi Hibi
J Immunol 2009 183: 1724-1731. Published online July 10, 2009; doi:10.4049/jimmunol.0804369 [Abstract] [Full Text] [PDF]  

IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens

Wendy A. Neveu, Jenna B. Allard, Oliver Dienz, Matthew J. Wargo, Gennaro Ciliberto, Laurie A. Whittaker, and Mercedes Rincon
J Immunol 2009 183: 1732-1738. Published online July 10, 2009; doi:10.4049/jimmunol.0802923 [Abstract] [Full Text] [PDF]  

Mast Cell-Dependent Contraction of Human Airway Smooth Muscle Cell-Containing Collagen Gels: Influence of Cytokines, Matrix Metalloproteases, and Serine Proteases

Alexander Margulis, Karl H. Nocka, Agnes M. Brennan, Bijia Deng, Margaret Fleming, Samuel J. Goldman, and Marion T. Kasaian
J Immunol 2009 183: 1739-1750. Published online July 10, 2009; doi:10.4049/jimmunol.0803951 [Abstract] [Full Text] [PDF]  

Late Endosome/Lysosome-Localized Rab7b Suppresses TLR9-Initiated Proinflammatory Cytokine and Type I IFN Production in Macrophages

Ming Yao, Xingguang Liu, Dong Li, Taoyong Chen, Zhen Cai, and Xuetao Cao
J Immunol 2009 183: 1751-1758. Published online July 8, 2009; doi:10.4049/jimmunol.0900249 [Abstract] [Full Text] [PDF] Data Supplement  

An Engineered GM-CSF-CCL2 Fusokine Is a Potent Inhibitor of CCR2-Driven Inflammation As Demonstrated in a Murine Model of Inflammatory Arthritis

Moutih Rafei, Yamina A. Berchiche, Elena Birman, Marie-Noëlle Boivin, Yoon Kow Young, Jian Hui Wu, Nikolaus Heveker, and Jacques Galipeau
J Immunol 2009 183: 1759-1766. Published online July 10, 2009; doi:10.4049/jimmunol.0900523 [Abstract] [Full Text] [PDF]  

Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism

Simona Podgrabinska, Okebugwu Kamalu, Lloyd Mayer, Motomu Shimaoka, Hans Snoeck, Gwendalyn J. Randolph, and Mihaela Skobe
J Immunol 2009 183: 1767-1779. Published online July 8, 2009; doi:10.4049/jimmunol.0802167 [Abstract] [Full Text] [PDF] Data Supplement  

Distinct Requirements for CD1d Intracellular Transport for Development of V14 iNKT Cells

Fenna C. M. Sillé, Mike Boxem, Dave Sprengers, Natacha Veerapen, Gurdyal Besra, and Marianne Boes
J Immunol 2009 183: 1780-1788. Published online July 8, 2009; doi:10.4049/jimmunol.0901354 [Abstract] [Full Text] [PDF] Data Supplement  

The Lytic Potential of Human Liver NK Cells Is Restricted by Their Limited Expression of Inhibitory Killer Ig-Like Receptors

Bryan M. Burt, George Plitas, Zeguo Zhao, Zubin M. Bamboat, Hoang M. Nguyen, Bo Dupont, and Ronald P. DeMatteo
J Immunol 2009 183: 1789-1796. Published online July 8, 2009; doi:10.4049/jimmunol.0900541 [Abstract] [Full Text] [PDF] Data Supplement  

Deletion of the C-Terminal Region of Dengue Virus Nonstructural Protein 1 (NS1) Abolishes Anti-NS1-Mediated Platelet Dysfunction and Bleeding Tendency

Mei-Chun Chen, Chiou-Feng Lin, Huan-Yao Lei, Shih-Chao Lin, Hsiao-Sheng Liu, Trai-Ming Yeh, Robert Anderson, and Yee-Shin Lin
J Immunol 2009 183: 1797-1803. Published online July 10, 2009; doi:10.4049/jimmunol.0800672 [Abstract] [Full Text] [PDF] Data Supplement  

SLP-76 Couples Syk to the Osteoclast Cytoskeleton

Jennifer L. Reeve, Wei Zou, Yuli Liu, Jonathan S. Maltzman, F. Patrick Ross, and Steven L. Teitelbaum
J Immunol 2009 183: 1804-1812. Published online July 10, 2009; doi:10.4049/jimmunol.0804206 [Abstract] [Full Text] [PDF] Data Supplement  

Intracellular Replication-Deficient Leishmania donovani Induces Long Lasting Protective Immunity against Visceral Leishmaniasis

Angamuthu Selvapandiyan, Ranadhir Dey, Susanne Nylen, Robert Duncan, David Sacks, and Hira L. Nakhasi
J Immunol 2009 183: 1813-1820. Published online July 10, 2009; doi:10.4049/jimmunol.0900276 [Abstract] [Full Text] [PDF] Data Supplement  

Antigen Specificity Is not Required for Modulation of Lung Allergic Responses by Naturally Occurring Regulatory T Cells

Anthony Joetham, Katsuyuki Takeda, Masakazu Okamoto, Christian Taube, Hiroyuki Matsuda, Azzeddine Dakhama, and Erwin W. Gelfand
J Immunol 2009 183: 1821-1827. Published online July 10, 2009; doi:10.4049/jimmunol.0900303 [Abstract] [Full Text] [PDF]  

Recurrence of Intracranial Tumors following Adoptive T Cell Therapy Can Be Prevented by Direct and Indirect Killing Aided by High Levels of Tumor Antigen Cross-Presented on Stromal Cells

Diana L. Thomas, Miri Kim, Natalie A. Bowerman, Samanthi Narayanan, David M. Kranz, Hans Schreiber, and Edward J. Roy
J Immunol 2009 183: 1828-1837. Published online July 10, 2009; doi:10.4049/jimmunol.0802322 [Abstract] [Full Text] [PDF] Data Supplement  

Human B Cells Secrete Granzyme B When Recognizing Viral Antigens in the Context of the Acute Phase Cytokine IL-21

Magdalena Hagn, Elisabeth Schwesinger, Verena Ebel, Kai Sontheimer, Julia Maier, Thamara Beyer, Tatiana Syrovets, Yves Laumonnier, Dorit Fabricius, Thomas Simmet, and Bernd Jahrsdörfer
J Immunol 2009 183: 1838-1845. Published online July 10, 2009; doi:10.4049/jimmunol.0901066 [Abstract] [Full Text] [PDF] Data Supplement  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

A Critical Role for REV1 in Regulating the Induction of C:G Transitions and A:T Mutations during Ig Gene Hypermutation

Keiji Masuda, Rika Ouchida, Yingqian Li, Xiang Gao, Hiromi Mori, and Ji-Yang Wang
J Immunol 2009 183: 1846-1850. Published online July 8, 2009; doi:10.4049/jimmunol.0901240 [Abstract] [Full Text] [PDF] Data Supplement  

Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

Agnes Wyzgol, Nicole Müller, Andrea Fick, Sabine Munkel, Goetz Ulrich Grigoleit, Klaus Pfizenmaier, and Harald Wajant
J Immunol 2009 183: 1851-1861. Published online July 13, 2009; doi:10.4049/jimmunol.0802597 [Abstract] [Full Text] [PDF]  

The Mechanism of Osteoclast Differentiation Induced by IL-1

Jung Ha Kim, Hye Mi Jin, Kabsun Kim, Insun Song, Bang Ung Youn, Koichi Matsuo, and Nacksung Kim
J Immunol 2009 183: 1862-1870. Published online July 8, 2009; doi:10.4049/jimmunol.0803007 [Abstract] [Full Text] [PDF] Data Supplement  

Flexible Stereospecific Interactions and Composition within Nucleoprotein Complexes Assembled on the TCR Gene Enhancer

Beatriz del Blanco, Joseph L. Roberts, Noelia Zamarreño, Nadège Balmelle-Devaux, and Cristina Hernández-Munain
J Immunol 2009 183: 1871-1883. Published online July 13, 2009; doi:10.4049/jimmunol.0803351 [Abstract] [Full Text] [PDF] Data Supplement  

Novel MHC Class I Structures on Exosomes

Sarah Lynch, Susana G. Santos, Elaine C. Campbell, Ailish M. S. Nimmo, Catherine Botting, Alan Prescott, Antony N. Antoniou, and Simon J. Powis
J Immunol 2009 183: 1884-1891. Published online July 13, 2009; doi:10.4049/jimmunol.0900798 [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Genetically Detoxified Pertussis Toxin Induces Th1/Th17 Immune Response through MAPKs and IL-10-Dependent Mechanisms

Maria Nasso, Giorgio Fedele, Fabiana Spensieri, Raffaella Palazzo, Paolo Costantino, Rino Rappuoli, and Clara Maria Ausiello
J Immunol 2009 183: 1892-1899. Published online July 13, 2009; doi:10.4049/jimmunol.0901071 [Abstract] [Full Text] [PDF]  

Selective Expansion of the Monocytic Lineage Directed by Bacterial Infection

Natalya V. Serbina, Tobias M. Hohl, Mathew Cherny, and Eric G. Pamer
J Immunol 2009 183: 1900-1910. Published online July 13, 2009; doi:10.4049/jimmunol.0900612 [Abstract] [Full Text] [PDF]  

CD1d-Based Combination Therapy Eradicates Established Tumors in Mice

Michele W. L. Teng, Janelle Sharkey, Nicole M. McLaughlin, Mark A. Exley, and Mark J. Smyth
J Immunol 2009 183: 1911-1920; doi:10.4049/jimmunol.0900796 [Abstract] [Full Text] [PDF]  

The p110 Isoform of Phosphatidylinositol 3-Kinase Controls Susceptibility to Leishmania major by Regulating Expansion and Tissue Homing of Regulatory T Cells

Dong Liu, Tingting Zhang, Aaron J. Marshall, Klaus Okkenhaug, Bart Vanhaesebroeck, and Jude E. Uzonna
J Immunol 2009 183: 1921-1933. Published online July 13, 2009; doi:10.4049/jimmunol.0901099 [Abstract] [Full Text] [PDF]  

IL-13 Receptor 2 Regulates the Immune and Functional Response to Nippostrongylus brasiliensis Infection

Motoko Morimoto, Aiping Zhao, Rex Sun, Jennifer Stiltz, Kathleen B. Madden, Margaret Mentink-Kane, Thirumalai Ramalingam, Thomas A. Wynn, Joseph F. Urban, Jr., and Terez Shea-Donohue
J Immunol 2009 183: 1934-1939. Published online July 8, 2009; doi:10.4049/jimmunol.0804299 [Abstract] [Full Text] [PDF]  

NKG2D-Dependent IL-17 Production by Human T Cells in Response to an Intracellular Pathogen

Padmaja Paidipally, Sivakumar Periasamy, Peter F. Barnes, Rohan Dhiman, Mohanalaxmi Indramohan, David E. Griffith, David Cosman, and Ramakrishna Vankayalapati
J Immunol 2009 183: 1940-1945. Published online July 8, 2009; doi:10.4049/jimmunol.0803578 [Abstract] [Full Text] [PDF]  

B and T Lymphocyte Attenuator Tempers Early Infection Immunity

Yonglian Sun, Nicholas K. Brown, Matthew J. Ruddy, Mendy L. Miller, Youjin Lee, Yang Wang, Kenneth M. Murphy, Klaus Pfeffer, Lieping Chen, Jonathan Kaye, and Yang-Xin Fu
J Immunol 2009 183: 1946-1951. Published online July 8, 2009; doi:10.4049/jimmunol.0801866 [Abstract] [Full Text] [PDF]  

Pneumococcal Interaction with Human Dendritic Cells: Phagocytosis, Survival, and Induced Adaptive Immune Response Are Manipulated by PavA

Nadja Noske, Ulrike Kämmerer, Manfred Rohde, and Sven Hammerschmidt
J Immunol 2009 183: 1952-1963. Published online July 1, 2009; doi:10.4049/jimmunol.0804383 [Abstract] [Full Text] [PDF]  

The CCL7-CCL2-CCR2 Axis Regulates IL-4 Production in Lungs and Fungal Immunity

Wendy A. Szymczak and George S. Deepe, Jr
J Immunol 2009 183: 1964-1974. Published online July 8, 2009; doi:10.4049/jimmunol.0901316 [Abstract] [Full Text] [PDF]  

Microarray Analysis of Lymphatic Tissue Reveals Stage-Specific, Gene Expression Signatures in HIV-1 Infection

Qingsheng Li, Anthony J. Smith, Timothy W. Schacker, John V. Carlis, Lijie Duan, Cavan S. Reilly, and Ashley T. Haase
J Immunol 2009 183: 1975-1982. Published online July 13, 2009; doi:10.4049/jimmunol.0803222 [Abstract] [Full Text] [PDF] Data Supplement  

Alveolar Macrophages Transport Pathogens to Lung Draining Lymph Nodes

Alun C. Kirby, Mark C. Coles, and Paul M. Kaye
J Immunol 2009 183: 1983-1989; doi:10.4049/jimmunol.0901089 [Abstract] [Full Text] [PDF]  

Lack of CD200 Enhances Pathological T Cell Responses during Influenza Infection

Tomasz P. Rygiel, Eva S. K. Rijkers, Talitha de Ruiter, Ellen H. Stolte, Martin van der Valk, Guus F. Rimmelzwaan, Louis Boon, Anton M. van Loon, Frank E. Coenjaerts, Robert M. Hoek, Kiki Tesselaar, and Linde Meyaard
J Immunol 2009 183: 1990-1996. Published online July 8, 2009; doi:10.4049/jimmunol.0900252 [Abstract] [Full Text] [PDF]  

Mycobacterium abscessus Glycopeptidolipids Mask Underlying Cell Wall Phosphatidyl-myo-Inositol Mannosides Blocking Induction of Human Macrophage TNF- by Preventing Interaction with TLR2

Elizabeth R. Rhoades, Angela S. Archambault, Rebecca Greendyke, Fong-Fu Hsu, Cassandra Streeter, and Thomas F. Byrd
J Immunol 2009 183: 1997-2007. Published online July 13, 2009; doi:10.4049/jimmunol.0802181 [Abstract] [Full Text] [PDF] Data Supplement  

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

Stephen B. Willingham, Irving C. Allen, Daniel T. Bergstralh, Willie June Brickey, Max Tze-Han Huang, Debra J. Taxman, Joseph A. Duncan, and Jenny P.-Y. Ting
J Immunol 2009 183: 2008-2015. Published online July 8, 2009; doi:10.4049/jimmunol.0900138 [Abstract] [Full Text] [PDF] Data Supplement  

STAT1 Negatively Regulates Lung Basophil IL-4 Expression Induced by Respiratory Syncytial Virus Infection

Martin L. Moore, Dawn C. Newcomb, Vrajesh V. Parekh, Luc Van Kaer, Robert D. Collins, Weisong Zhou, Kasia Goleniewska, Michael H. Chi, Daphne Mitchell, Joshua A. Boyce, Joan E. Durbin, Carla Sturkie, and R. Stokes Peebles, Jr
J Immunol 2009 183: 2016-2026. Published online July 8, 2009; doi:10.4049/jimmunol.0803167 [Abstract] [Full Text] [PDF]  

TREM-1 Activation Alters the Dynamics of Pulmonary IRAK-M Expression In Vivo and Improves Host Defense during Pneumococcal Pneumonia

Heimo Lagler, Omar Sharif, Isabella Haslinger, Ulrich Matt, Karin Stich, Tanja Furtner, Bianca Doninger, Katharina Schmid, Rainer Gattringer, Alex F. de Vos, and Sylvia Knapp
J Immunol 2009 183: 2027-2036. Published online July 13, 2009; doi:10.4049/jimmunol.0803862 [Abstract] [Full Text] [PDF]  

INFLAMMATION:

IL-27 Regulates Homeostasis of the Intestinal CD4⁺ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis

Amy E. Troy, Colby Zaph, Yurong Du, Betsy C. Taylor, Katherine J. Guild, Christopher A. Hunter, Christiaan J. M. Saris, and David Artis
J Immunol 2009 183: 2037-2044. Published online July 13, 2009; doi:10.4049/jimmunol.0802918 [Abstract] [Full Text] [PDF]  

Suppression of Regulatory T Cells by IL-12p40 Homodimer via Nitric Oxide

Saurav Brahmachari and Kalipada Pahan
J Immunol 2009 183: 2045-2058. Published online July 8, 2009; doi:10.4049/jimmunol.0800276 [Abstract] [Full Text] [PDF]  

Esculetin Restores Mitochondrial Dysfunction and Reduces Allergic Asthma Features in Experimental Murine Model

Ulaganathan Mabalirajan, Amit Kumar Dinda, Surendra Kumar Sharma, and Balaram Ghosh
J Immunol 2009 183: 2059-2067. Published online July 1, 2009; doi:10.4049/jimmunol.0900342 [Abstract] [Full Text] [PDF]  

TNF- Preconditioning Protects Neurons via Neuron-Specific Up-Regulation of CREB-Binding Protein

Ramendra N. Saha, Anamitra Ghosh, Carlos A. Palencia, Yiu K. Fung, Serena M. Dudek, and Kalipada Pahan
J Immunol 2009 183: 2068-2078. Published online July 13, 2009; doi:10.4049/jimmunol.0801892 [Abstract] [Full Text] [PDF]  

Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enhances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis

Albert Quintana, Marcus Müller, Ricardo F. Frausto, Raquel Ramos, Daniel R. Getts, Elisenda Sanz, Markus J. Hofer, Marius Krauthausen, Nicholas J. C. King, Juan Hidalgo, and Iain L. Campbell
J Immunol 2009 183: 2079-2088. Published online July 13, 2009; doi:10.4049/jimmunol.0900242 [Abstract] [Full Text] [PDF] Data Supplement  

Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans

Thea Morris, Melanie Stables, Adrian Hobbs, Patricia de Souza, Paul Colville-Nash, Tim Warner, Justine Newson, Geoffrey Bellingan, and Derek W. Gilroy
J Immunol 2009 183: 2089-2096. Published online July 13, 2009; doi:10.4049/jimmunol.0900477 [Abstract] [Full Text] [PDF]  

Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis

Wen-Qi Lai, Anastasia Windy Irwan, Hong Heng Goh, Alirio J. Melendez, Iain B. McInnes, and Bernard P. Leung
J Immunol 2009 183: 2097-2103. Published online July 13, 2009; doi:10.4049/jimmunol.0804376 [Abstract] [Full Text] [PDF]  

Crystal-Induced Neutrophil Activation: XI. Implication and Novel Roles of Classical Protein Kinase C

Oana Popa-Nita, Sophie Proulx, Guillaume Paré, Emmanuelle Rollet-Labelle, and Paul H. Naccache
J Immunol 2009 183: 2104-2114. Published online July 13, 2009; doi:10.4049/jimmunol.0900906 [Abstract] [Full Text] [PDF]  

Maternal Exposure to Secondhand Cigarette Smoke Primes the Lung for Induction of Phosphodiesterase-4D5 Isozyme and Exacerbated Th2 Responses: Rolipram Attenuates the Airway Hyperreactivity and Muscarinic Receptor Expression but Not Lung Inflammation and Atopy

Shashi P. Singh, Neerad C. Mishra, Jules Rir-sima-ah, Mathew Campen, Viswanath Kurup, Seddigheh Razani-Boroujerdi, and Mohan L. Sopori
J Immunol 2009 183: 2115-2121. Published online July 13, 2009; doi:10.4049/jimmunol.0900826 [Abstract] [Full Text] [PDF]  

Dying and Necrotic Neutrophils Are Anti-Inflammatory Secondary to the Release of -Defensins

Katherine Miles, David J. Clarke, Wuyuan Lu, Zaneta Sibinska, Paula E. Beaumont, Donald J. Davidson, Tom A. Barr, Dominic J. Campopiano, and Mohini Gray
J Immunol 2009 183: 2122-2132. Published online July 13, 2009; doi:10.4049/jimmunol.0804187 [Abstract] [Full Text] [PDF]  

Suplatast Tosilate Inhibits Histamine Signaling by Direct and Indirect Down-Regulation of Histamine H₁ Receptor Gene Expression through Suppression of Histidine Decarboxylase and IL-4 Gene Transcriptions

Masum Shahriar, Hiroyuki Mizuguchi, Kazutaka Maeyama, Yoshiaki Kitamura, Naoki Orimoto, Shuhei Horio, Hayato Umehara, Masashi Hattori, Noriaki Takeda, and Hiroyuki Fukui
J Immunol 2009 183: 2133-2141. Published online July 13, 2009; doi:10.4049/jimmunol.0901058 [Abstract] [Full Text] [PDF]  

Skin and Peripheral Lymph Node Invariant NKT Cells Are Mainly Retinoic Acid Receptor-Related Orphan Receptor t⁺ and Respond Preferentially under Inflammatory Conditions

Jean-Marc Doisne, Chantal Becourt, Latiffa Amniai, Nadia Duarte, Jean-Benoît Le Luduec, Gérard Eberl, and Kamel Benlagha
J Immunol 2009 183: 2142-2149. Published online July 8, 2009; doi:10.4049/jimmunol.0901059 [Abstract] [Full Text] [PDF] Data Supplement  

MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

Jin Hou, Pin Wang, Li Lin, Xingguang Liu, Feng Ma, Huazhang An, Zhugang Wang, and Xuetao Cao
J Immunol 2009 183: 2150-2158. Published online July 13, 2009; doi:10.4049/jimmunol.0900707 [Abstract] [Full Text] [PDF] Data Supplement  

IL-8 Regulates Mucin Gene Expression at the Posttranscriptional Level in Lung Epithelial Cells

Maria V. Bautista, Yajun Chen, Vessela S. Ivanova, Michael K. Rahimi, Alan M. Watson, and Mary C. Rose
J Immunol 2009 183: 2159-2166. Published online July 13, 2009; doi:10.4049/jimmunol.0803022 [Abstract] [Full Text] [PDF]  

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

Aisleen McColl, Stylianos Bournazos, Sandra Franz, Mauro Perretti, B. Paul Morgan, Christopher Haslett, and Ian Dransfield
J Immunol 2009 183: 2167-2175. Published online July 13, 2009; doi:10.4049/jimmunol.0803503 [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area

Greta E. Weiss, Peter D. Crompton, Shanping Li, Laura A. Walsh, Susan Moir, Boubacar Traore, Kassoum Kayentao, Aissata Ongoiba, Ogobara K. Doumbo, and Susan K. Pierce
J Immunol 2009 183: 2176-2182. Published online July 10, 2009; doi:10.4049/jimmunol.0901297 [Abstract] [Full Text] [PDF]  

JAK3 Inhibition Significantly Attenuates Psoriasiform Skin Inflammation in CD18 Mutant PL/J Mice

Betty Y. Chang, Feifei Zhao, Xiaodong He, Hong Ren, Sylvia Braselmann, Vanessa Taylor, Joan Wicks, Donald G. Payan, Elliott B. Grossbard, Polly R. Pine, and Daniel C. Bullard
J Immunol 2009 183: 2183-2192. Published online July 13, 2009; doi:10.4049/jimmunol.0804063 [Abstract] [Full Text] [PDF] Data Supplement  

LETTERS OF RETRACTION:

Retraction: Endogenous IL-15 Sustains Recruitment of IL-2Rβ and Common and IL-2-Mediated Chemokine Production in Normal and Inflamed Human Gingival Fibroblasts

Akiko Ozawa, Hiroyuki Tada, Yumiko Sugawara, Akiko Uehara, Takashi Sasano, Hidetoshi Shimauchi, Haruhiko Takada, and Shunji Sugawara
J Immunol 2009 183: 2193; doi:10.4049/jimmunol.0990052 [Full Text] [PDF]  

CORRECTIONS:

Impaired NFAT transcriptional activity in antigen-stimulated CD8 T cells linked to defective phosphorylation of NFAT transactivation domain

S. Leung-Theung-Long, I. Mondor, M. Guiraud, C. Lamare, V. Nageleekar, P. E. Paulet, M. Rincon, and S. Guerder
J Immunol 2009 183: 2194; doi:10.4049/jimmunol.0990057 [Full Text] [PDF]  

Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients

C. del Fresno, F. García-Rio, V. Gómez-Piña, A. Soares-Schanoski, I. Fernández-Ruíz, T. Jurado, T. Kajiji, C. Shu, E. Marín, A. Gutierrez del Arroyo, C. Prados, F. Amalich, P. Fuentes-Prior, S. K. Biswas, and E. López-Collazo
J Immunol 2009 183: 2194; doi:10.4049/jimmunol.0990049 [Full Text] [PDF]  

Sequential mechanisms of cyclophosphamide-induced skin allograft tolerance including the intrathymic clonal deletion followed by late breakdown of the clonal deletion

M. Eto, H. Mayumi, Y. Tomita, Y. Yoshikai, Y. Nishimura, and K. Nomoto
J Immunol 2009 183: 2194; doi:10.4049/jimmunol.0990051 [Full Text] [PDF]  

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