IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2008 181: 7433-7434 [Full Text] [PDF] ImmunoCast  

PILLARS OF IMMUNOLOGY:

Bringing the Thymus to the Bench

Graham Anderson and Eric J. Jenkinson
J Immunol 2008 181: 7435-7436 [Full Text] [PDF] [Original Pillars Article]  

Pillars Article: Generation of T-cell Function in Organ Culture of Foetal Mouse Thymus. I. Mitogen Responsiveness

J. H. Robinson and J. J. T. Owen
J Immunol 2008 181: 7437-7444 [PDF]  

CUTTING EDGE:

Cutting Edge: CD4⁺ T Cell-Derived IL-2 Is Essential for Help-Dependent Primary CD8⁺ T Cell Responses

Elizabeth B. Wilson and Alexandra M. Livingstone
J Immunol 2008 181: 7445-7448 [Abstract] [Full Text] [PDF]  

Cutting Edge: The Idd3 Genetic Interval Determines Regulatory T Cell Function through CD11b⁺CD11c^– APC

Ana C. Anderson, Rucha Chandwaskar, David H. Lee, and Vijay K. Kuchroo
J Immunol 2008 181: 7449-7452 [Abstract] [Full Text] [PDF] Data Supplement  

Cutting Edge: Viral Infection Breaks NK Cell Tolerance to "Missing Self"

Joseph C. Sun and Lewis L. Lanier
J Immunol 2008 181: 7453-7457 [Abstract] [Full Text] [PDF]  

Cutting Edge: Selective Blockade of LIGHT-Lymphotoxin β Receptor Signaling Protects Mice from Experimental Cerebral Malaria Caused by Plasmodium berghei ANKA

Louise M. Randall, Fiona H. Amante, Yonghong Zhou, Amanda C. Stanley, Ashraful Haque, Fabian Rivera, Klaus Pfeffer, Stefanie Scheu, Geoff R. Hill, Koji Tamada, and Christian R. Engwerda
J Immunol 2008 181: 7458-7462 [Abstract] [Full Text] [PDF]  

Cutting Edge: Members of the Staphylococcus aureus Extracellular Fibrinogen-Binding Protein Family Inhibit the Interaction of C3d with Complement Receptor 2

Daniel Ricklin, Salome K. Ricklin-Lichtsteiner, Maciej M. Markiewski, Brian V. Geisbrecht, and John D. Lambris
J Immunol 2008 181: 7463-7467 [Abstract] [Full Text] [PDF]  

Cutting Edge: Migration of Langerhans Dendritic Cells Is Impaired in Autoimmune Dermatitis

Anna U. Eriksson and Ram Raj Singh
J Immunol 2008 181: 7468-7472 [Abstract] [Full Text] [PDF] Data Supplement  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Requirement of IL-17RA in Con A Induced Hepatitis and Negative Regulation of IL-17 Production in Mouse T Cells

Takako Nagata, Laura Mckinley, Jacques J. Peschon, John F. Alcorn, Shean J. Aujla, and Jay K. Kolls
J Immunol 2008 181: 7473-7479 [Abstract] [Full Text] [PDF] Data Supplement  

Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4⁺ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis

Gopal Murugaiyan, Akanksha Mittal, and Howard L. Weiner
J Immunol 2008 181: 7480-7488 [Abstract] [Full Text] [PDF]  

NK Cells Induce Apoptosis in Tubular Epithelial Cells and Contribute to Renal Ischemia-Reperfusion Injury

Zhu-Xu Zhang, Shuang Wang, Xuyan Huang, Wei-Ping Min, Hongtao Sun, Weihua Liu, Bertha Garcia, and Anthony M. Jevnikar
J Immunol 2008 181: 7489-7498 [Abstract] [Full Text] [PDF]  

Inhibition of the Alloimmune Response through the Generation of Regulatory T Cells by a MHC Class II-Derived Peptide

Weiping Zang, Marvin Lin, Safa Kalache, Nan Zhang, Bernd Krüger, Ana Maria Waaga-Gasser, Martin Grimm, Wayne Hancock, Peter Heeger, Bernd Schröppel, and Barbara Murphy
J Immunol 2008 181: 7499-7506 [Abstract] [Full Text] [PDF]  

Lin^–Sca1⁺Kit^– Bone Marrow Cells Contain Early Lymphoid-Committed Precursors That Are Distinct from Common Lymphoid Progenitors

Ritu Kumar, Valentina Fossati, Mason Israel, and Hans-Willem Snoeck
J Immunol 2008 181: 7507-7513 [Abstract] [Full Text] [PDF]  

Resolution of Unique Sca-1^highc-Kit^– Lymphoid-Biased Progenitors in Adult Bone Marrow

Benjamin C. Harman, Daniel L. Northrup, and David Allman
J Immunol 2008 181: 7514-7524 [Abstract] [Full Text] [PDF]  

Retinal Pigment Epithelium-Derived CTLA-2 Induces TGFβ-Producing T Regulatory Cells

Sunao Sugita, Shintaro Horie, Orie Nakamura, Yuri Futagami, Hiroshi Takase, Hiroshi Keino, Hiroyuki Aburatani, Nobuhiko Katunuma, Kazumi Ishidoh, Yoshimi Yamamoto, and Manabu Mochizuki
J Immunol 2008 181: 7525-7536 [Abstract] [Full Text] [PDF]  

Deregulation of c-Myc Confers Distinct Survival Requirements for Memory B Cells, Plasma Cells, and Their Progenitors

Sefat E. Khuda, William M. Loo, Siegfried Janz, Brian Van Ness, and Loren D. Erickson
J Immunol 2008 181: 7537-7549 [Abstract] [Full Text] [PDF]  

Targeting the Neonatal Fc Receptor for Antigen Delivery Using Engineered Fc Fragments

Wentao Mi, Sylvia Wanjie, Su-Tang Lo, Zhuo Gan, Beatrix Pickl-Herk, Raimund J. Ober, and E. Sally Ward
J Immunol 2008 181: 7550-7561 [Abstract] [Full Text] [PDF]  

Uncoupling of Induced Protein Processing from Maturation in Dendritic Cells Exposed to a Highly Antigenic Preparation from a Helminth Parasite

Fraser A. Marshall and Edward J. Pearce
J Immunol 2008 181: 7562-7570 [Abstract] [Full Text] [PDF] Data Supplement  

Transplantation of Bone Marrow Transduced to Express Self-Antigen Establishes Deletional Tolerance and Permanently Remits Autoimmune Disease

James Chan, Ee Jun Ban, Keng Hao Chun, Shunhe Wang, B. Thomas Bäckström, Claude C. A. Bernard, Ban-Hock Toh, and Frank Alderuccio
J Immunol 2008 181: 7571-7580 [Abstract] [Full Text] [PDF]  

A New Approach to the Blocking of Alloreactive T Cell-Mediated Graft-versus-Host Disease by In Vivo Administration of Anti-CXCR3 Neutralizing Antibody

Shan He, Qi Cao, Yuhua Qiu, Jianqing Mi, Jingwu Z. Zhang, Min Jin, Hailiang Ge, Stephen G. Emerson, Yi Zhang, and Yanyun Zhang
J Immunol 2008 181: 7581-7592 [Abstract] [Full Text] [PDF]  

Drak2 Regulates the Survival of Activated T Cells and Is Required for Organ-Specific Autoimmune Disease

Maureen A. McGargill, Carmen Choy, Ben G. Wen, and Stephen M. Hedrick
J Immunol 2008 181: 7593-7605 [Abstract] [Full Text] [PDF]  

Enhanced T Cell Apoptosis within Drak2-Deficient Mice Promotes Resistance to Autoimmunity

Stephanie J. Ramos, Jeniffer B. Hernandez, Martina Gatzka, and Craig M. Walsh
J Immunol 2008 181: 7606-7616 [Abstract] [Full Text] [PDF] Data Supplement  

The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival

Warren N. D'Souza, Chiung-Fang Chang, April M. Fischer, Manqing Li, and Stephen M. Hedrick
J Immunol 2008 181: 7617-7629 [Abstract] [Full Text] [PDF]  

The Immunosuppressor Mycophenolic Acid Kills Activated Lymphocytes by Inducing a Nonclassical Actin-Dependent Necrotic Signal

Benjamin Chaigne-Delalande, Gwendaline Guidicelli, Lionel Couzi, Pierre Merville, Walid Mahfouf, Stéphane Bouchet, Mathieu Molimard, Benoit Pinson, Jean-François Moreau, and Patrick Legembre
J Immunol 2008 181: 7630-7638 [Abstract] [Full Text] [PDF]  

Signals and Sequences That Control CD28 Localization to the Central Region of the Immunological Synapse

Mariano Sanchez-Lockhart, Beth Graf, and Jim Miller
J Immunol 2008 181: 7639-7648 [Abstract] [Full Text] [PDF] Data Supplement  

Abnormal Regulatory and Effector T Cell Function Predispose to Autoimmunity following Xenogeneic Thymic Transplantation

Yasuhiro Fudaba, Takashi Onoe, Meredith Chittenden, Akira Shimizu, Juanita M. Shaffer, Roderick Bronson, and Megan Sykes
J Immunol 2008 181: 7649-7659 [Abstract] [Full Text] [PDF] Data Supplement  

Galectin-9 Increases Tim-3⁺ Dendritic Cells and CD8⁺ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions

Keiko Nagahara, Tomohiro Arikawa, Souichi Oomizu, Keiichi Kontani, Atsuya Nobumoto, Hiroaki Tateno, Kota Watanabe, Toshiro Niki, Shigeki Katoh, Minoru Miyake, Syun-Ichiro Nagahata, Jun Hirabayashi, Vijay K. Kuchroo, Akira Yamauchi, and Mitsuomi Hirashima
J Immunol 2008 181: 7660-7669 [Abstract] [Full Text] [PDF] Data Supplement  

Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN-/β

Soo M. Ngoi, Michael G. Tovey, and Anthony T. Vella
J Immunol 2008 181: 7670-7680 [Abstract] [Full Text] [PDF]  

Dynamic Modulation of CCR7 Expression and Function on Naive T Lymphocytes In Vivo

Mirjam R. Britschgi, Alexander Link, Tonje Katrine A. Lissandrin, and Sanjiv A. Luther
J Immunol 2008 181: 7681-7688 [Abstract] [Full Text] [PDF]  

Retinoic Acids Are Potent Inhibitors of Spontaneous Human Eosinophil Apoptosis

Shigeharu Ueki, Gulixian Mahemuti, Hajime Oyamada, Hikari Kato, Junko Kihara, Masako Tanabe, Wataru Ito, Takahito Chiba, Masahide Takeda, Hiroyuki Kayaba, and Junichi Chihara
J Immunol 2008 181: 7689-7698 [Abstract] [Full Text] [PDF]  

The Role of Thymic Stromal Lymphopoietin in CD8⁺ T Cell Homeostasis

Yrina Rochman and Warren J. Leonard
J Immunol 2008 181: 7699-7705 [Abstract] [Full Text] [PDF]  

The Phosphoinositide 3-Kinase-Dependent Activation of Btk Is Required for Optimal Eicosanoid Production and Generation of Reactive Oxygen Species in Antigen-Stimulated Mast Cells

Hye Sun Kuehn, Emily J. Swindle, Mi-Sun Kim, Michael A. Beaven, Dean D. Metcalfe, and Alasdair M. Gilfillan
J Immunol 2008 181: 7706-7712 [Abstract] [Full Text] [PDF]  

An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency

Alessandra Marini, Jill M. Harper, and Fabio Romerio
J Immunol 2008 181: 7713-7720 [Abstract] [Full Text] [PDF]  

Enhancement in Specific CD8⁺ T Cell Recognition of EphA2⁺ Tumors In Vitro and In Vivo after Treatment with Ligand Agonists

Amy K. Wesa, Christopher J. Herrem, Maja Mandic, Jennifer L. Taylor, Cecilia Vasquez, Mayumi Kawabe, Tomohide Tatsumi, Michael S. Leibowitz, James H. Finke, Ronald M. Bukowski, Elizabeth Bruckheimer, Michael S. Kinch, and Walter J. Storkus
J Immunol 2008 181: 7721-7727 [Abstract] [Full Text] [PDF]  

Self-Antigen Prevents CD8 T Cell Effector Differentiation by CD134 and CD137 Dual Costimulation

Suman Bandyopadhyay, Meixiao Long, Harry Z. Qui, Adam T. Hagymasi, Aaron M. Slaiby, Marianne A. Mihalyo, Hector L. Aguila, Robert S. Mittler, Anthony T. Vella, and Adam J. Adler
J Immunol 2008 181: 7728-7737 [Abstract] [Full Text] [PDF]  

Photoaffinity Antigens for Human T Cells

Ghanashyam Sarikonda, Hong Wang, Kia-Joo Puan, Xiao-hui Liu, Hoi K. Lee, Yongcheng Song, Mark D. Distefano, Eric Oldfield, Glenn D. Prestwich, and Craig T. Morita
J Immunol 2008 181: 7738-7750 [Abstract] [Full Text] [PDF]  

Coexpression of TGF-β1 and IL-10 Enables Regulatory T Cells to Completely Suppress Airway Hyperreactivity

Katrin Presser, Dorothee Schwinge, Michael Wegmann, Samuel Huber, Steffen Schmitt, Alexander Quaas, Joachim H. Maxeiner, Susetta Finotto, Ansgar W. Lohse, Manfred Blessing, and Christoph Schramm
J Immunol 2008 181: 7751-7758 [Abstract] [Full Text] [PDF]  

Rapid Deletion of Antigen-Specific CD4⁺ T Cells following Infection Represents a Strategy of Immune Evasion and Persistence for Anaplasma marginale

Sushan Han, Junzo Norimine, Guy H. Palmer, Waithaka Mwangi, Kevin K. Lahmers, and Wendy C. Brown
J Immunol 2008 181: 7759-7769 [Abstract] [Full Text] [PDF]  

T Cell-Independent Spontaneous Loss of Tolerance by Anti-Double-Stranded DNA B Cells in C57BL/6 Mice

Patricia Y. Tsao, Jing Jiao, Mei Qing Ji, Philip L. Cohen, and Robert A. Eisenberg
J Immunol 2008 181: 7770-7777 [Abstract] [Full Text] [PDF]  

Egr2 Is Required for Bcl-2 Induction during Positive Selection

Jens-Peter Holst Lauritsen, Sridevi Kurella, Sang-Yun Lee, Juliette M. Lefebvre, Michele Rhodes, José Alberola-Ila, and David L. Wiest
J Immunol 2008 181: 7778-7785 [Abstract] [Full Text] [PDF]  

TCR Down-Regulation Controls Virus-Specific CD8⁺ T Cell Responses

Charlotte Menné Bonefeld, Mariëlle Haks, Bodil Nielsen, Marina von Essen, Lasse Boding, Ann Kathrine Hansen, Jeppe Madura Larsen, Niels Ødum, Paul Krimpenfort, Ada Kruisbeek, Jan Pravsgaard Christensen, Allan Randrup Thomsen, and Carsten Geisler
J Immunol 2008 181: 7786-7799 [Abstract] [Full Text] [PDF]  

TNF Receptor-Associated Factor 5 Is Required for Optimal T Cell Expansion and Survival in Response to Infection

Zachary J. Kraus, Jodie S. Haring, and Gail A. Bishop
J Immunol 2008 181: 7800-7809 [Abstract] [Full Text] [PDF] Data Supplement  

Granzyme C Supports Efficient CTL-Mediated Killing Late in Primary Alloimmune Responses

Yonas Getachew, Heather Stout-Delgado, Bonnie C. Miller, and Dwain L. Thiele
J Immunol 2008 181: 7810-7817 [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

The Magnitude of Thymic Output Is Genetically Determined through Controlled Intrathymic Precursor T Cell Proliferation

Gaël Dulude, Remi Cheynier, Dominique Gauchat, Ali Abdallah, Nadia Kettaf, Rafick-Pierre Sékaly, and Sophie Gratton
J Immunol 2008 181: 7818-7824 [Abstract] [Full Text] [PDF]  

An Activation-Induced Cytidine Deaminase-Independent Mechanism of Secondary V_H Gene Rearrangement in Preimmune Human B Cells

Nancy S. Longo, Gabrielle J. Grundy, Jisoo Lee, Martin Gellert, and Peter E. Lipsky
J Immunol 2008 181: 7825-7834 [Abstract] [Full Text] [PDF]  

Induction of A:T Mutations Is Dependent on Cellular Environment but Independent of Mutation Frequency and Target Gene Location

Akiko Ukai, Konomi Ishimaru, Rika Ouchida, Hiromi Mori, Chie Kano, Toshiyuki Moritan, and Ji-Yang Wang
J Immunol 2008 181: 7835-7842 [Abstract] [Full Text] [PDF] Data Supplement  

MHC Class II Presentation of gp100 Epitopes in Melanoma Cells Requires the Function of Conventional Endosomes and Is Influenced by Melanosomes

Valentina Robila, Marina Ostankovitch, Michelle L. Altrich-VanLith, Alexander C. Theos, Sheila Drover, Michael S. Marks, Nicholas Restifo, and Victor H. Engelhard
J Immunol 2008 181: 7843-7852 [Abstract] [Full Text] [PDF]  

TCR β-Chain Sharing in Human CD8⁺ T Cell Responses to Cytomegalovirus and EBV

Vanessa Venturi, Hui Yee Chin, Tedi E. Asher, Kristin Ladell, Phillip Scheinberg, Ethan Bornstein, David van Bockel, Anthony D. Kelleher, Daniel C. Douek, David A. Price, and Miles P. Davenport
J Immunol 2008 181: 7853-7862 [Abstract] [Full Text] [PDF] Data Supplement  

TREM-2 Mediated Signaling Induces Antigen Uptake and Retention in Mature Myeloid Dendritic Cells

Suresh Radhakrishnan, Laura N. Arneson, Jadee L. Upshaw, Charles L. Howe, Sara J. Felts, Marco Colonna, Paul J. Leibson, Moses Rodriguez, and Larry R. Pease
J Immunol 2008 181: 7863-7872 [Abstract] [Full Text] [PDF]  

The Secretion and Uptake of Lysosomal Phospholipase A₂ by Alveolar Macrophages

Akira Abe, Robert Kelly, Jessica Kollmeyer, Miki Hiraoka, Ye Lu, and James A. Shayman
J Immunol 2008 181: 7873-7881 [Abstract] [Full Text] [PDF]  

RGS13 Controls G Protein-Coupled Receptor-Evoked Responses of Human Mast Cells

Geetanjali Bansal, Jeffrey A. DiVietro, Hye Sun Kuehn, Sudhir Rao, Karl H. Nocka, Alasdair M. Gilfillan, and Kirk M. Druey
J Immunol 2008 181: 7882-7890 [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

Silke M. Schulz, Gabriele Köhler, Nicole Schütze, Jens Knauer, Reinhard K. Straubinger, Alissa A. Chackerian, Ellen Witte, Kerstin Wolk, Robert Sabat, Yoichiro Iwakura, Christoph Holscher, Uwe Müller, Robert A. Kastelein, and Gottfried Alber
J Immunol 2008 181: 7891-7901 [Abstract] [Full Text] [PDF]  

Complement Receptor of the Ig Superfamily Enhances Complement-Mediated Phagocytosis in a Subpopulation of Tissue Resident Macrophages

Nick N. Gorgani, Jeannie Q. He, Kenneth J. Katschke, Jr., Karim Y. Helmy, Hongkang Xi, Micah Steffek, Philip E. Hass, and Menno van Lookeren Campagne
J Immunol 2008 181: 7902-7908 [Abstract] [Full Text] [PDF]  

Mucosal Clearance of Capsule-Expressing Bacteria Requires Both TLR and Nucleotide-Binding Oligomerization Domain 1 Signaling

Tracey A. Zola, Elena S. Lysenko, and Jeffrey N. Weiser
J Immunol 2008 181: 7909-7916 [Abstract] [Full Text] [PDF]  

A Novel IFN Regulatory Factor 3-Dependent Pathway Activated by Trypanosomes Triggers IFN-β in Macrophages and Fibroblasts

Anne-Danielle C. Chessler, Ludmila R. P. Ferreira, Tun-Han Chang, Katherine A. Fitzgerald, and Barbara A. Burleigh
J Immunol 2008 181: 7917-7924 [Abstract] [Full Text] [PDF]  

Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity

Joao Gamelas Magalhaes, Jörg H. Fritz, Lionel Le Bourhis, Gernot Sellge, Leonardo H. Travassos, Thirumahal Selvanantham, Stephen E. Girardin, Jennifer L. Gommerman, and Dana J. Philpott
J Immunol 2008 181: 7925-7935 [Abstract] [Full Text] [PDF]  

Multimerization of Surfactant Protein D, but Not Its Collagen Domain, Is Required for Antiviral and Opsonic Activities Related to Influenza Virus

Mitchell White, Paul Kingma, Tesfaldet Tecle, Nilgun Kacak, Bruce Linders, John Heuser, Erika Crouch, and Kevan Hartshorn
J Immunol 2008 181: 7936-7943 [Abstract] [Full Text] [PDF]  

Interaction between RANTES Promoter Variant and CCR532 Favors Recovery from Hepatitis B

Chloe L. Thio, Jacquie Astemborski, Rasmi Thomas, Timothy Mosbruger, Mallory D. Witt, James J. Goedert, Keith Hoots, Cherie Winkler, David L. Thomas, and Mary Carrington
J Immunol 2008 181: 7944-7947 [Abstract] [Full Text] [PDF]  

Identification of Human T Cell Antigens for the Development of Vaccines against Mycobacterium tuberculosis

Sylvie Bertholet, Gregory C. Ireton, Maria Kahn, Jeffrey Guderian, Raodoh Mohamath, Nicole Stride, Elsa M. Laughlin, Susan L. Baldwin, Thomas S. Vedvick, Rhea N. Coler, and Steven G. Reed
J Immunol 2008 181: 7948-7957 [Abstract] [Full Text] [PDF]  

The Number of Respiratory Syncytial Virus (RSV)-Specific Memory CD8 T Cells in the Lung Is Critical for Their Ability to Inhibit RSV Vaccine-Enhanced Pulmonary Eosinophilia

Matthew R. Olson, Stacey M. Hartwig, and Steven M. Varga
J Immunol 2008 181: 7958-7968 [Abstract] [Full Text] [PDF]  

OX40 Drives Protective Vaccinia Virus-Specific CD8 T Cells

Shahram Salek-Ardakani, Magdalini Moutaftsi, Shane Crotty, Alessandro Sette, and Michael Croft
J Immunol 2008 181: 7969-7976 [Abstract] [Full Text] [PDF]  

Aging Mice Exhibit a Functional Defect in Mucosal Dendritic Cell Response against an Intracellular Pathogen

Magali M. Moretto, Elizabeth M. Lawlor, and Imtiaz A. Khan
J Immunol 2008 181: 7977-7984 [Abstract] [Full Text] [PDF]  

Dysregulation of CXCR3 Signaling due to CXCL10 Deficiency Impairs the Antiviral Response to Herpes Simplex Virus 1 Infection

Todd R. Wuest and Daniel J. J. Carr
J Immunol 2008 181: 7985-7993 [Abstract] [Full Text] [PDF]  

Factor C Acts as a Lipopolysaccharide-Responsive C3 Convertase in Horseshoe Crab Complement Activation

Shigeru Ariki, Shusaku Takahara, Toshio Shibata, Takaaki Fukuoka, Aya Ozaki, Yuichi Endo, Teizo Fujita, Takumi Koshiba, and Shun-ichiro Kawabata
J Immunol 2008 181: 7994-8001 [Abstract] [Full Text] [PDF] Data Supplement  

INFLAMMATION:

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

Sandra M. Sacre, Alexandra Lo, Bernard Gregory, Rachel E. Simmonds, Lynn Williams, Marc Feldmann, Fionula M. Brennan, and Brian M. Foxwell
J Immunol 2008 181: 8002-8009 [Abstract] [Full Text] [PDF]  

Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis

Wen-Qi Lai, Anastasia Windy Irwan, Hong Heng Goh, Hwee Siew Howe, David T. Yu, Rafael Valle-Oñate, Iain B. McInnes, Alirio J. Melendez, and Bernard P. Leung
J Immunol 2008 181: 8010-8017 [Abstract] [Full Text] [PDF]  

SOCS1 Regulates the IFN but Not NFB Pathway in TLR-Stimulated Human Monocytes and Macrophages

Cecilia M. Prêle, Eleanor A. Woodward, Jacqueline Bisley, April Keith-Magee, Sandra E. Nicholson, and Prue H. Hart
J Immunol 2008 181: 8018-8026 [Abstract] [Full Text] [PDF]  

Transgenic Expression of Cyclooxygenase-2 in Hepatocytes Accelerates Endotoxin-Induced Acute Liver Failure

Chang Han, Guiying Li, Kyu Lim, Marie C. DeFrances, Chandrashekhar R. Gandhi, and Tong Wu
J Immunol 2008 181: 8027-8035 [Abstract] [Full Text] [PDF]  

Persistence of Lung CD8 T Cell Oligoclonal Expansions upon Smoking Cessation in a Mouse Model of Cigarette Smoke-Induced Emphysema

Gregory T. Motz, Bryan L. Eppert, Guangyun Sun, Scott C. Wesselkamper, Michael J. Linke, Ranjan Deka, and Michael T. Borchers
J Immunol 2008 181: 8036-8043 [Abstract] [Full Text] [PDF] Data Supplement  

Multidrug Resistance-Associated Transporter 2 Regulates Mucosal Inflammation by Facilitating the Synthesis of Hepoxilin A₃

Michael Pazos, Dario Siccardi, Karen L. Mumy, Jeffrey D. Bien, Steve Louie, Hai Ning Shi, Karsten Gronert, Randall J. Mrsny, and Beth A. McCormick
J Immunol 2008 181: 8044-8052 [Abstract] [Full Text] [PDF]  

Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases

Dominik Hartl, Susanne Krauss-Etschmann, Barbara Koller, Peter L. Hordijk, Taco W. Kuijpers, Florian Hoffmann, Andreas Hector, Ernst Eber, Veronica Marcos, Iris Bittmann, Oliver Eickelberg, Matthias Griese, and Dirk Roos
J Immunol 2008 181: 8053-8067 [Abstract] [Full Text] [PDF]  

A Novel Targeted Inhibitor of the Alternative Pathway of Complement and Its Therapeutic Application in Ischemia/Reperfusion Injury

Yuxiang Huang, Fei Qiao, Carl Atkinson, V. Michael Holers, and Stephen Tomlinson
J Immunol 2008 181: 8068-8076 [Abstract] [Full Text] [PDF]  

Sulfatide, A Major Lipid Component of Myelin Sheath, Activates Inflammatory Responses As an Endogenous Stimulator in Brain-Resident Immune Cells

Sae-Bom Jeon, Hee Jung Yoon, Se-Ho Park, In-Hoo Kim, and Eun Jung Park
J Immunol 2008 181: 8077-8087 [Abstract] [Full Text] [PDF]  

CD40-Induced Signaling in Human Endothelial Cells Results in mTORC2- and Akt-Dependent Expression of Vascular Endothelial Growth Factor In Vitro and In Vivo

Olivier Dormond, Alan G. Contreras, Esther Meijer, Dipak Datta, Evelyn Flynn, Soumitro Pal, and David M. Briscoe
J Immunol 2008 181: 8088-8095 [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Promiscuous Interaction between Gold-Specific T Cells and APCs in Gold Allergy

Hideo Hashizume, Naohiro Seo, Taisuke Ito, Masahiro Takigawa, and Hiroaki Yagi
J Immunol 2008 181: 8096-8102 [Abstract] [Full Text] [PDF] Data Supplement  

Deficiency of HIV-Gag-Specific T Cells in Early Childhood Correlates with Poor Viral Containment

SiHong Huang, Jacqueline Dunkley-Thompson, YanHua Tang, Eric A. Macklin, Julianne Steel-Duncan, Indira Singh-Minott, Elizabeth G. Ryland, Monica Smikle, Bruce D. Walker, Celia D. C. Christie, and Margaret E. Feeney
J Immunol 2008 181: 8103-8111 [Abstract] [Full Text] [PDF]  

Intrarectal Vaccination with Recombinant Vaccinia Virus Expressing Carcinoembronic Antigen Induces Mucosal and Systemic Immunity and Prevents Progression of Colorectal Cancer

Seunghee Kim-Schulze, Hong Sung Kim, Alberto Wainstein, Dae Won Kim, Wein Cui Yang, Dorota Moroziewicz, Phyllus Y. Mong, Michal Bereta, Bret Taback, Qin Wang, and Howard L. Kaufman
J Immunol 2008 181: 8112-8119 [Abstract] [Full Text] [PDF] Data Supplement  

Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes

Paul V. Beum, David A. Mack, Andrew W. Pawluczkowycz, Margaret A. Lindorfer, and Ronald P. Taylor
J Immunol 2008 181: 8120-8132 [Abstract] [Full Text] [PDF]  

In Vivo BLyS/BAFF Neutralization Ameliorates Islet-Directed Autoimmunity in Nonobese Diabetic Mice

Ghazal Zekavat, Susan Y. Rostami, Armen Badkerhanian, Ronald F. Parsons, Brigitte Koeberlein, Ming Yu, Christopher D. Ward, Thi-Sau Migone, Liping Yu, George S. Eisenbarth, Michael P. Cancro, Ali Naji, and Hooman Noorchashm
J Immunol 2008 181: 8133-8144 [Abstract] [Full Text] [PDF]  

Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells

Sandeep Krishnan, Yuang-Taung Juang, Bhabadeb Chowdhury, Abigail Magilavy, Carolyn U. Fisher, Hang Nguyen, Madhusoodana P. Nambiar, Vasileios Kyttaris, Arthur Weinstein, Rena Bahjat, Polly Pine, Violeta Rus, and George C. Tsokos
J Immunol 2008 181: 8145-8152 [Abstract] [Full Text] [PDF]  

Restoration of Adenosine Deaminase-Deficient Human Thymocyte Development In Vitro by Inhibition of Deoxynucleoside Kinases

Michelle L. Joachims, Patrick A. Marble, Aletha B. Laurent, Peter Pastuszko, Marco Paliotta, Michael R. Blackburn, and Linda F. Thompson
J Immunol 2008 181: 8153-8161 [Abstract] [Full Text] [PDF]  

Detection of Complement Activation on Antigen Microarrays Generates Functional Antibody Profiles and Helps Characterization of Disease-Associated Changes of the Antibody Repertoire

Krisztián Papp, Péter Végh, Kata Miklós, Julianna Németh, Klára Rásky, Ferenc Péterfy, Anna Erdei, and József Prechl
J Immunol 2008 181: 8162-8169 [Abstract] [Full Text] [PDF] Data Supplement  

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IL-33 induced Ag-specific IL-5⁺ T cells and promotes allergic-induced airway inflammation independent of IL-4

M. Kurowska-Stolarska, P. Kewin, G. Murphy, R. C. Russo, B. Stolarski, C. C. Garcia, M. Komai-Koma, N. Pitman, Y. Li, A. N. J. McKenzie, M. M. Teixeira, F. Y. Liew, and D. Xu
J Immunol 2008 181: 8170 [Full Text] [PDF]  

Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1

C. S. McKimmie, A. R. Fraser, C. Hansell, L. Gutiérrez, S. Philipsen, L. Connell, A. Rot, M. Kurowska-Stolarska, P. Carreno, M. Pruenster, C.-C. Chu, G. Lombardi, C. Halsey, I. B. McInnes, F. Y. Liew, R. J. Nibbs, and G. J. Graham
J Immunol 2008 181: 8170-8181 [Full Text] [PDF]  

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