EDITORIALS:

Tomorrow’s JI Today

Jeremy M. Boss
J Immunol 2008 181: 1-2. [Full Text] [PDF]  

IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2008 181: 3-4. [Full Text] [PDF] ImmunoCast  

PILLARS OF IMMUNOLOGY:

First Demonstration of the Role of TNF in the Pathogenesis of Disease

Jan Vilcek
J Immunol 2008 181: 5-6. [Full Text] [PDF] [Original Pillars Article]  

Pillars Article: Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin. Science, 1985, 229(4716):869–871.

Bruce Beutler, Ian W. Milsark, and Anthony C. Cerami
J Immunol 2008 181: 7-9. [PDF]  

BRIEF REVIEWS:

Dendritic Cells as Killers: Mechanistic Aspects and Potential Roles

Camille Chauvin and Régis Josien
J Immunol 2008 181: 11-16. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3

Hanfen Li, Stephen B. Willingham, Jenny P.-Y. Ting, and Fabio Re
J Immunol 2008 181: 17-21. [Abstract] [Full Text] [PDF]  

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

Ni Cheng, Rong He, Jun Tian, Patrick P. Ye, and Richard D. Ye
J Immunol 2008 181: 22-26. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Systematic Comparison of Gene Expression between Murine Memory and Naive B Cells Demonstrates That Memory B Cells Have Unique Signaling Capabilities

Mary M. Tomayko, Shannon M. Anderson, Catherine E. Brayton, Saheli Sadanand, Natalie C. Steinel, Timothy W. Behrens, and Mark J. Shlomchik
J Immunol 2008 181: 27-38. [Abstract] [Full Text] [PDF] Data Supplement  

Killer Ig-Like Receptor Expression in Uterine NK Cells Is Biased toward Recognition of HLA-C and Alters with Gestational Age

Andrew M. Sharkey, Lucy Gardner, Susan Hiby, Lydia Farrell, Richard Apps, Leanne Masters, Jodie Goodridge, Louise Lathbury, C. Andrew Stewart, Sanjay Verma, and Ashley Moffett
J Immunol 2008 181: 39-46. [Abstract] [Full Text] [PDF]  

CTL-Promoting Effects of CD40 Stimulation Outweigh B Cell-Stimulatory Effects Resulting in B Cell Elimination and Disease Improvement in a Murine Model of Lupus

Roman Puliaev, Irina Puliaeva, Lisbeth A. Welniak, Abigail E. Ryan, Mark Haas, William J. Murphy, and Charles S. Via
J Immunol 2008 181: 47-61. [Abstract] [Full Text] [PDF]  

IL-1β-Driven ST2L Expression Promotes Maturation Resistance in Rapamycin-Conditioned Dendritic Cells

Heth R. Turnquist, Tina L. Sumpter, Allan Tsung, Alan F. Zahorchak, Atsunori Nakao, Gerard J. Nau, Foo Y. Liew, David A. Geller, and Angus W. Thomson
J Immunol 2008 181: 62-72. [Abstract] [Full Text] [PDF]  

Fetal Exposure to High-Avidity TCR Ligand Enhances Expansion of Peripheral T Regulatory Cells

Ping Yu, Cara L. Haymaker, Rohit D. Divekar, Jason S. Ellis, John Hardaway, Renu Jain, Danielle M. Tartar, Christine M. Hoeman, Jason A. Cascio, Austin Ostermeier, and Habib Zaghouani
J Immunol 2008 181: 73-80. [Abstract] [Full Text] [PDF]  

Critical Role for the Chemokine Receptor CXCR6 in Homeostasis and Activation of CD1d-Restricted NKT Cells

Elitza Germanov, Linnea Veinotte, Robyn Cullen, Erin Chamberlain, Eugene C. Butcher, and Brent Johnston
J Immunol 2008 181: 81-91. [Abstract] [Full Text] [PDF]  

Dual Role of CD38 in Microglial Activation and Activation-Induced Cell Death

Lior Mayo, Jasmine Jacob-Hirsch, Ninette Amariglio, Gideon Rechavi, Marie-Jo Moutin, Frances E. Lund, and Reuven Stein
J Immunol 2008 181: 92-103. [Abstract] [Full Text] [PDF]  

Stat6 Signaling Suppresses VLA-4 Expression by CD8⁺ T Cells and Limits Their Ability to Infiltrate Tumor Lesions In Vivo

Kotaro Sasaki, Xi Zhao, Angela D. Pardee, Ryo Ueda, Mitsugu Fujita, Sarita Sehra, Mark H. Kaplan, Lawrence P. Kane, Hideho Okada, and Walter J. Storkus
J Immunol 2008 181: 104-108. [Abstract] [Full Text] [PDF]  

An Age-Old Paradigm Challenged: Old Baboons Generate Vigorous Humoral Immune Responses to LcrV, A Plague Antigen

Sue Stacy, Amanda Pasquali, Valerie L. Sexton, Angelene M. Cantwell, Ellen Kraig, and Peter H. Dube
J Immunol 2008 181: 109-115. [Abstract] [Full Text] [PDF]  

Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis

Javier O. Jurado, Ivana B. Alvarez, Virginia Pasquinelli, Gustavo J. Martínez, María F. Quiroga, Eduardo Abbate, Rosa M. Musella, H. Eduardo Chuluyan, and Verónica E. García
J Immunol 2008 181: 116-125. [Abstract] [Full Text] [PDF]  

In Vitro and In Vivo Down-Regulation of Regulatory T Cell Activity with a Peptide Inhibitor of TGF-β1

Lucía Gil-Guerrero, Javier Dotor, Inge Louise Huibregtse, Noelia Casares, Ana Belén López-Vázquez, Francesc Rudilla, José Ignacio Riezu-Boj, Jacinto López-Sagaseta, José Hermida, Sander Van Deventer, Jaione Bezunartea, Diana Llopiz, Pablo Sarobe, Jesús Prieto, Francisco Borrás-Cuesta, and Juan José Lasarte
J Immunol 2008 181: 126-135. [Abstract] [Full Text] [PDF]  

Retrogenic Modeling of Experimental Allergic Encephalomyelitis Associates T Cell Frequency but Not TCR Functional Affinity with Pathogenicity

Rajshekhar Alli, Phuong Nguyen, and Terrence L. Geiger
J Immunol 2008 181: 136-145. [Abstract] [Full Text] [PDF]  

Identification of a Novel Immunogenic HLA-A*0201-Binding Epitope of HER-2/neu with Potent Antitumor Properties

Angelos D. Gritzapis, Ioannis F. Voutsas, Eftychia Lekka, Nikolaos Tsavaris, Ioannis Missitzis, Panagiota Sotiropoulou, Sonia Perez, Michael Papamichail, and Constantin N. Baxevanis
J Immunol 2008 181: 146-154. [Abstract] [Full Text] [PDF]  

Defective MHC Class II Presentation by Dendritic Cells Limits CD4 T Cell Help for Antitumor CD8 T Cell Responses

Michael Y. Gerner, Kerry A. Casey, and Matthew F. Mescher
J Immunol 2008 181: 155-164. [Abstract] [Full Text] [PDF]  

Alloreactive CD8 T Cell Tolerance Requires Recipient B Cells, Dendritic Cells, and MHC Class II

Thomas Fehr, Fabienne Haspot, Joshua Mollov, Meredith Chittenden, Timothy Hogan, and Megan Sykes
J Immunol 2008 181: 165-173. [Abstract] [Full Text] [PDF]  

Coligation of the Hepatitis C Virus Receptor CD81 with CD28 Primes Naive T Lymphocytes to Acquire Type 2 Effector Function

Alessandro Serra, Sandra Nuti, Simona Tavarini, Chiara Sammicheli, Domenico Rosa, Giulietta Saletti, Elisabetta Soldaini, Sergio Abrignani, and Andreas Wack
J Immunol 2008 181: 174-185. [Abstract] [Full Text] [PDF]  

B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones

Rie Takagi, Takehiro Higashi, Kumiko Hashimoto, Kazuhisa Nakano, Yosuke Mizuno, Yasushi Okazaki, and Sho Matsushita
J Immunol 2008 181: 186-189. [Abstract] [Full Text] [PDF]  

Th17 Cells Undergo Fas-Mediated Activation-Induced Cell Death Independent of IFN-

Yingyu Zhang, Guangwu Xu, Liying Zhang, Arthur I. Roberts, and Yufang Shi
J Immunol 2008 181: 190-196. [Abstract] [Full Text] [PDF]  

Apoptosis Supercedes Necrosis in Mitochondrial DNA-Depleted Jurkat Cells by Cleavage of Receptor-Interacting Protein and Inhibition of Lysosomal Cathepsin

Tsutomu Sato, Takuro Machida, Sho Takahashi, Kazuyuki Murase, Yutaka Kawano, Tsuyoshi Hayashi, Satoshi Iyama, Kohich Takada, Kageaki Kuribayashi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Takuya Matsunaga, Junji Kato, and Yoshiro Niitsu
J Immunol 2008 181: 197-207. [Abstract] [Full Text] [PDF]  

Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis Differently Modulate Human Dendritic Cell Functions Resulting in Divergent Prevalence of Th17-Polarized Responses

Giorgio Fedele, Maria Nasso, Fabiana Spensieri, Raffaella Palazzo, Loredana Frasca, Mineo Watanabe, and Clara M. Ausiello
J Immunol 2008 181: 208-216. [Abstract] [Full Text] [PDF]  

cis-Urocanic Acid Initiates Gene Transcription in Primary Human Keratinocytes

Kazuyo Kaneko, Ulrike Smetana-Just, Mary Matsui, Antony R. Young, Susan John, Mary Norval, and Susan L. Walker
J Immunol 2008 181: 217-224. [Abstract] [Full Text] [PDF]  

A Function for IL-7R for CD4⁺CD25⁺Foxp3⁺ T Regulatory Cells

Allison L. Bayer, Joon Youb Lee, Anabel de la Barrera, Charles D. Surh, and Thomas R. Malek
J Immunol 2008 181: 225-234. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-Activated Receptor- Regulates the Expression of Alveolar Macrophage Macrophage Colony-Stimulating Factor

Tracey L. Bonfield, Mary Jane Thomassen, Carol F. Farver, Susamma Abraham, Mary T. Koloze, Xia Zhang, David M. Mosser, and Daniel A. Culver
J Immunol 2008 181: 235-242. [Abstract] [Full Text] [PDF]  

The Proline-Rich Sequence of CD3 as an Amplifier of Low-Avidity TCR Signaling

Pankaj Tailor, Sue Tsai, Afshin Shameli, Pau Serra, Jinguo Wang, Stephen Robbins, Masao Nagata, Andrea L. Szymczak-Workman, Dario A. A. Vignali, and Pere Santamaria
J Immunol 2008 181: 243-255. [Abstract] [Full Text] [PDF]  

KDEL-Retained Antigen in B Lymphocytes Induces a Proinflammatory Response: A Possible Role for Endoplasmic Reticulum Stress in Adaptive T Cell Immunity

Matthew C. Wheeler, Marta Rizzi, Roman Sasik, Gonzalo Almanza, Gary Hardiman, and Maurizio Zanetti
J Immunol 2008 181: 256-264. [Abstract] [Full Text] [PDF]  

Characterization of Murine Cytomegalovirus m157 from Infected Cells and Identification of Critical Residues Mediating Recognition by the NK Cell Receptor Ly49H

Aja H. Davis, Natalya V. Guseva, Brianne L. Ball, and Jonathan W. Heusel
J Immunol 2008 181: 265-275. [Abstract] [Full Text] [PDF]  

Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF

Weifeng Xu, Paul A. Santini, Allysia J. Matthews, April Chiu, Alessandro Plebani, Bing He, Kang Chen, and Andrea Cerutti
J Immunol 2008 181: 276-287. [Abstract] [Full Text] [PDF]  

Dual Functions of Bruton’s Tyrosine Kinase and Tec Kinase during Fc Receptor-Induced Signaling and Phagocytosis

Jenny Jongstra-Bilen, Adrianet Puig Cano, Manvi Hasija, Haiyan Xiao, C. I. Edvard Smith, and Myron I. Cybulsky
J Immunol 2008 181: 288-298. [Abstract] [Full Text] [PDF]  

CD4 Help Regulates Expression of Crucial Genes Involved in CD8 T Cell Memory and Sensitivity to Regulatory Elements

Laetitia Rapetti, Sylvain Meunier, Christiane Pontoux, and Corinne Tanchot
J Immunol 2008 181: 299-308. [Abstract] [Full Text] [PDF]  

Evidence That CD8⁺ Dendritic Cells Enable the Development of T Cells That Modulate Airway Hyperresponsiveness

Laura Cook, Nobuaki Miyahara, Niyun Jin, J. M. Wands, Christian Taube, Christina L. Roark, Terry A. Potter, Erwin W. Gelfand, Rebecca L. O'Brien, and Willi K. Born
J Immunol 2008 181: 309-319. [Abstract] [Full Text] [PDF]  

Autoreactive T Cells Escape Clonal Deletion in the Thymus by a CD24-Dependent Pathway

Joseph W. Carl, Jr., Jin-Qing Liu, Pramod S. Joshi, Hani Y. El-Omrani, Lijie Yin, Xincheng Zheng, Caroline C. Whitacre, Yang Liu, and Xue-Feng Bai
J Immunol 2008 181: 320-328. [Abstract] [Full Text] [PDF]  

Development of Proteoglycan-Induced Arthritis Is Independent of IL-17

Paul D. Doodes, Yanxia Cao, Keith M. Hamel, Yumei Wang, Balint Farkas, Yoichiro Iwakura, and Alison Finnegan
J Immunol 2008 181: 329-337. [Abstract] [Full Text] [PDF]  

Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis

Patrizia De Sarno, Robert C. Axtell, Chander Raman, Kevin A. Roth, Dario R. Alessi, and Richard S. Jope
J Immunol 2008 181: 338-345. [Abstract] [Full Text] [PDF]  

Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma

Sergei Kusmartsev, Evgeniy Eruslanov, Hubert Kübler, Timothy Tseng, Yoshihisa Sakai, Zhen Su, Sergei Kaliberov, Axel Heiser, Charles Rosser, Philip Dahm, Dietmar Siemann, and Johannes Vieweg
J Immunol 2008 181: 346-353. [Abstract] [Full Text] [PDF]  

Dendritic Cells Require the NF-B2 Pathway for Cross-Presentation of Soluble Antigens

Evan F. Lind, Cory L. Ahonen, Anna Wasiuk, Yoko Kosaka, Burkhard Becher, Kathy A. Bennett, and Randolph J. Noelle
J Immunol 2008 181: 354-363. [Abstract] [Full Text] [PDF]  

Murine Low-Density Lipoprotein Receptor-Related Protein 1 (LRP) Is Required for Phagocytosis of Targets Bearing LRP Ligands but Is Not Required for C1q-Triggered Enhancement of Phagocytosis

Anna P. Lillis, Mallary C. Greenlee, Irina Mikhailenko, Salvatore V. Pizzo, Andrea J. Tenner, Dudley K. Strickland, and Suzanne S. Bohlson
J Immunol 2008 181: 364-373. [Abstract] [Full Text] [PDF]  

Quantitative Regulation of B Cell Division Destiny by Signal Strength

Marian L. Turner, Edwin D. Hawkins, and Philip D. Hodgkin
J Immunol 2008 181: 374-382. [Abstract] [Full Text] [PDF]  

IL-7 Specifies B Cell Fate at the Common Lymphoid Progenitor to Pre-ProB Transition Stage by Maintaining Early B Cell Factor Expression

Kazu Kikuchi, Hirotake Kasai, Akiko Watanabe, Anne Y. Lai, and Motonari Kondo
J Immunol 2008 181: 383-392. [Abstract] [Full Text] [PDF]  

Th1 and Th2 Cells Form Morphologically Distinct Immunological Synapses

Timothy J. Thauland, Yoshinobu Koguchi, Scott A. Wetzel, Michael L. Dustin, and David C. Parker
J Immunol 2008 181: 393-399. [Abstract] [Full Text] [PDF]  

Ltβr Signaling Does Not Regulate Aire-Dependent Transcripts in Medullary Thymic Epithelial Cells

Vera C. Martins, Thomas Boehm, and Conrad C. Bleul
J Immunol 2008 181: 400-407. [Abstract] [Full Text] [PDF] Data Supplement  

Functional Tolerance of CD8⁺ T Cells Induced by Muscle-Specific Antigen Expression

Sébastien Calbo, Héloïse Delagrèverie, Christophe Arnoult, François-Jérome Authier, François Tron, and Olivier Boyer
J Immunol 2008 181: 408-417. [Abstract] [Full Text] [PDF]  

Epidermal and Dermal Dendritic Cells Display Differential Activation and Migratory Behavior While Sharing the Ability to Stimulate CD4⁺ T Cell Proliferation In Vivo

Elena Shklovskaya, Ben Roediger, and Barbara Fazekas de St. Groth
J Immunol 2008 181: 418-430. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Comprehensive Analysis of HLA-DR- and HLA-DP4-Restricted CD4⁺ T Cell Response Specific for the Tumor-Shared Antigen Survivin in Healthy Donors and Cancer Patients

Xiao-Fei Wang, Jerome Kerzerho, Olivier Adotevi, Hélène Nuyttens, Cecile Badoual, Gaetan Munier, Stéphane Oudard, Shuiping Tu, Eric Tartour, and Bernard Maillère
J Immunol 2008 181: 431-439. [Abstract] [Full Text] [PDF]  

Human TCR /β⁺ CD4^–CD8^– Double-Negative T Cells in Patients with Autoimmune Lymphoproliferative Syndrome Express Restricted Vβ TCR Diversity and Are Clonally Related to CD8⁺ T Cells

Anne Bristeau-Leprince, Véronique Mateo, Annick Lim, Aude Magerus-Chatinet, Eric Solary, Alain Fischer, Frédéric Rieux-Laucat, and Marie-Lise Gougeon
J Immunol 2008 181: 440-448. [Abstract] [Full Text] [PDF]  

Activation of the JAK/STAT-1 Signaling Pathway by IFN- Can Down-Regulate Functional Expression of the MHC Class I-Related Neonatal Fc Receptor for IgG

Xindong Liu, Lilin Ye, Yu Bai, Habi Mojidi, Neil E. Simister, and Xiaoping Zhu
J Immunol 2008 181: 449-463. [Abstract] [Full Text] [PDF]  

CD73 Participates in Cellular Multiresistance Program and Protects against TRAIL-Induced Apoptosis

Andrey Mikhailov, Alice Sokolovskaya, Gennady G. Yegutkin, Hanne Amdahl, Anne West, Hideo Yagita, Riitta Lahesmaa, Linda F. Thompson, Sirpa Jalkanen, Dmitry Blokhin, and John E. Eriksson
J Immunol 2008 181: 464-475. [Abstract] [Full Text] [PDF]  

Subunit 1 of the Prefoldin Chaperone Complex Is Required for Lymphocyte Development and Function

Shang Cao, Gianluca Carlesso, Anna B. Osipovich, Joan Llanes, Qing Lin, Kristen L. Hoek, Wasif N. Khan, and H. Earl Ruley
J Immunol 2008 181: 476-484. [Abstract] [Full Text] [PDF]  

Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes

Lance R. Thomas, Hiroki Miyashita, Robin Milley Cobb, Steven Pierce, Makoto Tachibana, Elias Hobeika, Michael Reth, Yoichi Shinkai, and Eugene M. Oltz
J Immunol 2008 181: 485-493. [Abstract] [Full Text] [PDF]  

MEK1/2 Induces STAT5-Mediated Germline Transcription of the TCR Locus in Response to IL-7R Signaling

Kazushige Maki and Koichi Ikuta
J Immunol 2008 181: 494-502. [Abstract] [Full Text] [PDF]  

Dynamic Protein Associations Define Two Phases of IL-1β Transcriptional Activation

Yue Zhang, Simona Saccani, Hyunjin Shin, and Barbara S. Nikolajczyk
J Immunol 2008 181: 503-512. [Abstract] [Full Text] [PDF]  

A Critical Role for Protein Kinase C--Mediated T Cell Survival in Cardiac Allograft Rejection

Santhakumar Manicassamy, Dengping Yin, Zheng Zhang, Luciana L. Molinero, Marisa-Luisa Alegre, and Zuoming Sun
J Immunol 2008 181: 513-520. [Abstract] [Full Text] [PDF]  

The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages

Ivan Dzhagalov, Alexis Dunkle, and You-Wen He
J Immunol 2008 181: 521-528. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Innate Responses to Systemic Infection by Intracellular Bacteria Trigger Recruitment of Ly-6C^high Monocytes to the Brain

Douglas A. Drevets, Jennifer E. Schawang, Marilyn J. Dillon, Megan R. Lerner, Michael S. Bronze, and Daniel J. Brackett
J Immunol 2008 181: 529-536. [Abstract] [Full Text] [PDF]  

Haemophilus influenzae Interacts with the Human Complement Inhibitor Factor H

Teresia Hallström, Peter F. Zipfel, Anna M. Blom, Nadine Lauer, Arne Forsgren, and Kristian Riesbeck
J Immunol 2008 181: 537-545. [Abstract] [Full Text] [PDF]  

Differential CMV-Specific CD8⁺ Effector T Cell Responses in the Lung Allograft Predominate over the Blood during Human Primary Infection

Matthew R. Pipeling, Erin E. West, Christine M. Osborne, Amanda B. Whitlock, Lesia K. Dropulic, Matthew H. Willett, Michael Forman, Alexandra Valsamakis, Jonathan B. Orens, David R. Moller, Noah Lechtzin, Stephen A. Migueles, Mark Connors, and John F. McDyer
J Immunol 2008 181: 546-556. [Abstract] [Full Text] [PDF]  

Endogenous IL-32 Controls Cytokine and HIV-1 Production

Marcel F. Nold, Claudia A. Nold-Petry, Gregory B. Pott, Jarod A. Zepp, Milene T. Saavedra, Soo-Hyun Kim, and Charles A. Dinarello
J Immunol 2008 181: 557-565. [Abstract] [Full Text] [PDF]  

IFN-/β Signaling Is Required for Polarization of Cytokine Responses toward a Protective Type 1 Pattern during Experimental Cryptococcosis

Carmelo Biondo, Angelina Midiri, Maria Gambuzza, Elisabetta Gerace, Maria Falduto, Roberta Galbo, Antonella Bellantoni, Concetta Beninati, Giuseppe Teti, Tomas Leanderson, and Giuseppe Mancuso
J Immunol 2008 181: 566-573. [Abstract] [Full Text] [PDF]  

Nonmucosal Alphavirus Vaccination Stimulates a Mucosal Inductive Environment in the Peripheral Draining Lymph Node

Joseph M. Thompson, Michael G. Nicholson, Alan C. Whitmore, Melodie Zamora, Ande West, Akiko Iwasaki, Herman F. Staats, and Robert E. Johnston
J Immunol 2008 181: 574-585. [Abstract] [Full Text] [PDF]  

Control of Pseudomonas aeruginosa in the Lung Requires the Recognition of Either Lipopolysaccharide or Flagellin

Reuben Ramphal, Viviane Balloy, Jeevan Jyot, Amrisha Verma, Mustapha Si-Tahar, and Michel Chignard
J Immunol 2008 181: 586-592. [Abstract] [Full Text] [PDF]  

MyD88 Regulation of Fusarium Keratitis Is Dependent on TLR4 and IL-1R1 but Not TLR2

Ahmad B. Tarabishy, Bishr Aldabagh, Yan Sun, Yoshifumi Imamura, Pranab K. Mukherjee, Jonathan H. Lass, Mahmoud A. Ghannoum, and Eric Pearlman
J Immunol 2008 181: 593-600. [Abstract] [Full Text] [PDF]  

Surfactant Protein A Binds to HIV and Inhibits Direct Infection of CD4⁺ Cells, but Enhances Dendritic Cell-Mediated Viral Transfer

Gaurav D. Gaiha, Tao Dong, Nades Palaniyar, Daniel A. Mitchell, Kenneth B. M. Reid, and Howard W. Clark
J Immunol 2008 181: 601-609. [Abstract] [Full Text] [PDF]  

CCR2 Mediates Conventional Dendritic Cell Recruitment and the Formation of Bronchovascular Mononuclear Cell Infiltrates in the Lungs of Mice Infected with Cryptococcus neoformans

John J. Osterholzer, Jeffrey L. Curtis, Timothy Polak, Theresa Ames, Gwo-Hsiao Chen, Rod McDonald, Gary B. Huffnagle, and Galen B. Toews
J Immunol 2008 181: 610-620. [Abstract] [Full Text] [PDF]  

Macrophage Dysfunction and Susceptibility to Pulmonary Pseudomonas aeruginosa Infection in Surfactant Protein C-Deficient Mice

Stephan W. Glasser, Albert P. Senft, Jeffrey A. Whitsett, Melissa D. Maxfield, Gary F. Ross, Theresa R. Richardson, Daniel R. Prows, Yan Xu, and Thomas R. Korfhagen
J Immunol 2008 181: 621-628. [Abstract] [Full Text] [PDF]  

Sequential Binding of Cytosolic Phox Complex to Phagosomes through Regulated Adaptor Proteins: Evaluation Using the Novel Monomeric Kusabira-Green System and Live Imaging of Phagocytosis

Takehiko Ueyama, Tomoko Kusakabe, Satoshi Karasawa, Takumi Kawasaki, Aya Shimizu, Jeonghyun Son, Thomas L. Leto, Atsushi Miyawaki, and Naoaki Saito
J Immunol 2008 181: 629-640. [Abstract] [Full Text] [PDF]  

Chronic Alcohol Consumption Increases the Severity of Murine Influenza Virus Infections

David K. Meyerholz, Michelle Edsen-Moore, Jodi McGill, Ruth A. Coleman, Robert T. Cook, and Kevin L. Legge
J Immunol 2008 181: 641-648. [Abstract] [Full Text] [PDF]  

Terminal Deoxynucleotidyl Transferase Establishes and Broadens Antiviral CD8⁺ T Cell Immunodominance Hierarchies

S. M. Mansour Haeryfar, Heather D. Hickman, Kari R. Irvine, David C. Tscharke, Jack R. Bennink, and Jonathan W. Yewdell
J Immunol 2008 181: 649-659. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Potent Anti-Inflammatory and Neuroprotective Effects of TGF-β1 Are Mediated through the Inhibition of ERK and p47^phox-Ser³⁴⁵ Phosphorylation and Translocation in Microglia

Li Qian, Sung-Jen Wei, Dan Zhang, Xiaoming Hu, Zongli Xu, Belinda Wilson, Jamel El-Benna, Jau-Shyong Hong, and Patrick M. Flood
J Immunol 2008 181: 660-668. [Abstract] [Full Text] [PDF]  

IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis

Lone Skov, Frank J. Beurskens, Claus O. C. Zachariae, Sakari Reitamo, Jessica Teeling, David Satijn, Kim M. Knudsen, Elmieke P. J. Boot, Debra Hudson, Ole Baadsgaard, Paul W. H. I. Parren, and Jan G. J. van de Winkel
J Immunol 2008 181: 669-679. [Abstract] [Full Text] [PDF]  

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

Nadia G. Innamorato, Ana I. Rojo, Ángel J. García-Yagüe, Masayuki Yamamoto, María L. de Ceballos, and Antonio Cuadrado
J Immunol 2008 181: 680-689. [Abstract] [Full Text] [PDF]  

Cathepsin B Is Involved in the Trafficking of TNF--Containing Vesicles to the Plasma Membrane in Macrophages

Soon-Duck Ha, Andrew Martins, Khashayarsha Khazaie, Jiahuai Han, Bosco M. C. Chan, and Sung Ouk Kim
J Immunol 2008 181: 690-697. [Abstract] [Full Text] [PDF]  

Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage

Gary Chan, Elizabeth R. Bivins-Smith, M. Shane Smith, Patrick M. Smith, and Andrew D. Yurochko
J Immunol 2008 181: 698-711. [Abstract] [Full Text] [PDF] Data Supplement  

Altered Function of Factor I Caused by Amyloid β: Implication for Pathogenesis of Age-Related Macular Degeneration from Drusen

Jiying Wang, Kyoko Ohno-Matsui, Takeshi Yoshida, Ariko Kojima, Noriaki Shimada, Ken-ichi Nakahama, Olga Safranova, Nobuhisa Iwata, Takaomi C. Saido, Manabu Mochizuki, and Ikuo Morita
J Immunol 2008 181: 712-720. [Abstract] [Full Text] [PDF]  

In Vitro Differentiation of Dendritic Cells in the Presence of Prostaglandin E₂ Alters the IL-12/IL-23 Balance and Promotes Differentiation of Th17 Cells

Tanzilya Khayrullina, Jui-Hung Yen, Huie Jing, and Doina Ganea
J Immunol 2008 181: 721-735. [Abstract] [Full Text] [PDF]  

Acrolein Inhalation Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production but Does Not Affect Acute Airways Neutrophilia

David Itiro Kasahara, Matthew E. Poynter, Ziryan Othman, David Hemenway, and Albert van der Vliet
J Immunol 2008 181: 736-745. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

The Anergic State in Sarcoidosis Is Associated with Diminished Dendritic Cell Function

Sneha Mathew, Kristy L. Bauer, Arne Fischoeder, Nina Bhardwaj, and Stephen J. Oliver
J Immunol 2008 181: 746-755. [Abstract] [Full Text] [PDF]  

Identification of Annexin 1 as a Novel Autoantigen in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Katsushi Kurosu, Yuichi Takiguchi, Osamu Okada, Norio Yumoto, Seiichiro Sakao, Yuji Tada, Yasunori Kasahara, Nobuhiro Tanabe, Koichiro Tatsumi, Michael Weiden, William N. Rom, and Takayuki Kuriyama
J Immunol 2008 181: 756-767. [Abstract] [Full Text] [PDF]  

Contribution of Antibody and T Cell-Specific Responses to the Progression of 139A-Scrapie in C57BL/6 Mice Immunized with Prion Protein Peptides

Antoine Sacquin, Anne Sophie Bergot, Pierre Aucouturier, and Martine Bruley-Rosset
J Immunol 2008 181: 768-775. [Abstract] [Full Text] [PDF]  

Immunization of Malignant Melanoma Patients with Full-Length NY-ESO-1 Protein Using TLR7 Agonist Imiquimod as Vaccine Adjuvant

Sylvia Adams, David W. O'Neill, Daisuke Nonaka, Elizabeth Hardin, Luis Chiriboga, Kimberly Siu, Crystal M. Cruz, Angelica Angiulli, Francesca Angiulli, Erika Ritter, Rose Marie Holman, Richard L. Shapiro, Russell S. Berman, Natalie Berner, Yongzhao Shao, Olivier Manches, Linda Pan, Ralph R. Venhaus, Eric W. Hoffman, Achim Jungbluth, Sacha Gnjatic, Lloyd Old, Anna C. Pavlick, and Nina Bhardwaj
J Immunol 2008 181: 776-784. [Abstract] [Full Text] [PDF]  

B Lymphocyte Autoimmunity in Rheumatoid Synovitis Is Independent of Ectopic Lymphoid Neogenesis

Tineke Cantaert, Johanna Kolln, Trieneke Timmer, Tineke C. van der Pouw Kraan, Bernard Vandooren, Rogier M. Thurlings, Juan D. Cañete, Anca I. Catrina, Theo Out, Cor L. Verweij, Yiping Zhang, Paul P. Tak, and Dominique Baeten
J Immunol 2008 181: 785-794. [Abstract] [Full Text] [PDF]  

Thyroglobulin Peptides Associate In Vivo to HLA-DR in Autoimmune Thyroid Glands

Laia Muixí, Montserrat Carrascal, Iñaki Alvarez, Xavier Daura, Mercè Martí, Maria Pilar Armengol, Clemencia Pinilla, Joaquín Abian, Ricardo Pujol-Borrell, and Dolores Jaraquemada
J Immunol 2008 181: 795-807. [Abstract] [Full Text] [PDF]  

Fusions of Dendritic Cells with Breast Carcinoma Stimulate the Expansion of Regulatory T Cells while Concomitant Exposure to IL-12, CpG Oligodeoxynucleotides, and Anti-CD3/CD28 Promotes the Expansion of Activated Tumor Reactive Cells

Baldev Vasir, Zekui Wu, Keith Crawford, Jacalyn Rosenblatt, Corrine Zarwan, Adam Bissonnette, Donald Kufe, and David Avigan
J Immunol 2008 181: 808-821. [Abstract] [Full Text] [PDF]  

Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis

Paul V. Beum, Margaret A. Lindorfer, Frank Beurskens, P. Todd Stukenberg, Henk M. Lokhorst, Andrew W. Pawluczkowycz, Paul W. H. I. Parren, Jan G. J. van de Winkel, and Ronald P. Taylor
J Immunol 2008 181: 822-832. [Abstract] [Full Text] [PDF] Data Supplement  

Global T Cell Dysregulation in Non-Autoimmune-Prone Mice Promotes Rapid Development of BAFF-Independent, Systemic Lupus Erythematosus-Like Autoimmunity

William Stohl, Noam Jacob, William J. Quinn, III, Michael P. Cancro, Huaxin Gao, Chaim Putterman, Xiaoni Gao, Luminita Pricop, and Michael N. Koss
J Immunol 2008 181: 833-841. [Abstract] [Full Text] [PDF]  

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