IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2008 180: 7053-7054. [Full Text] [PDF]  

PILLARS OF IMMUNOLOGY:

Wu and Kabat 1970: A Transforming View of Antibody Diversity

Leroy E. Hood
J Immunol 2008 180: 7055-7056. [Full Text] [PDF] [Original Pillars Article]  

Pillars Article: An Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and Myeloma Light Chains and their Implications for Antibody Complementarity. J. Exp. Med. 1970. 132: 211–250.

Tai Te Wu and Elvin A. Kabat
J Immunol 2008 180: 7057-7096. [PDF]  

CUTTING EDGE:

Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune Encephalomyelitis

Jonathan M. Coquet, Sumone Chakravarti, Mark J. Smyth, and Dale I. Godfrey
J Immunol 2008 180: 7097-7101. [Abstract] [Full Text] [PDF]  

Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells

Eva M. Briso, Oliver Dienz, and Mercedes Rincon
J Immunol 2008 180: 7102-7106. [Abstract] [Full Text] [PDF]  

Cutting Edge: K63-Linked Polyubiquitination of NEMO Modulates TLR Signaling and Inflammation In Vivo

Chang-Yuan Ni, Zhao-Hui Wu, William C. Florence, Vrajesh V. Parekh, Maria Pia Arrate, Steven Pierce, Brock Schweitzer, Luc Van Kaer, Sebastian Joyce, Shigeki Miyamoto, Dean W. Ballard, and Eugene M. Oltz
J Immunol 2008 180: 7107-7111. [Abstract] [Full Text] [PDF]  

Cutting Edge: Foxp3⁺CD4⁺CD25⁺ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

Song Guo Zheng, Juhua Wang, and David A. Horwitz
J Immunol 2008 180: 7112-7116. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Plasticity of Regulatory T Cells: Subversion of Suppressive Function and Conversion to Enhancement of Lung Allergic Responses

Anthony Joetham, Shigeki Matsubara, Masakazu Okamoto, Katsuyuki Takeda, Nobuaki Miyahara, Azzeddine Dakhama, and Erwin W. Gelfand
J Immunol 2008 180: 7117-7124. [Abstract] [Full Text] [PDF]  

Small Interfering RNAs Induce Macrophage Migration Inhibitory Factor Production and Proliferation in Breast Cancer Cells via a Double-Stranded RNA-Dependent Protein Kinase-Dependent Mechanism

Michelle E. Armstrong, Michael Gantier, Lili Li, Wen Y. Chung, Amanda McCann, John A. Baugh, and Seamas C. Donnelly
J Immunol 2008 180: 7125-7133. [Abstract] [Full Text] [PDF]  

TLR Ligand-Induced Type I IFNs Affect Thymopoiesis

Marie-Laurence Baron, Dominique Gauchat, Ross La Motte-Mohs, Nadia Kettaf, Ali Abdallah, Thomas Michiels, Juan-Carlos Zúñiga-Pflücker, and Rafick-Pierre Sékaly
J Immunol 2008 180: 7134-7146. [Abstract] [Full Text] [PDF]  

P2X₇ Receptor Differentially Couples to Distinct Release Pathways for IL-1β in Mouse Macrophage

Pablo Pelegrin, Consuelo Barroso-Gutierrez, and Annmarie Surprenant
J Immunol 2008 180: 7147-7157. [Abstract] [Full Text] [PDF]  

Differential Effects of the Type I Interferons ₄, β, and on Antiviral Activity and Vaccine Efficacy

Stephanie L. Day, Ian A. Ramshaw, Alistair J. Ramsay, and Charani Ranasinghe
J Immunol 2008 180: 7158-7166. [Abstract] [Full Text] [PDF]  

Differential Regulation of Antigen-Specific CD8⁺ T Cell Responses by IL-12p40 in a Dose-Dependent Manner

Doo-Jin Kim, Je-In Youn, Sang-Hwan Seo, Hyun-Tak Jin, and Young-Chul Sung
J Immunol 2008 180: 7167-7174. [Abstract] [Full Text] [PDF]  

Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

Hiroaki Shime, Masahiko Yabu, Takashi Akazawa, Ken Kodama, Misako Matsumoto, Tsukasa Seya, and Norimitsu Inoue
J Immunol 2008 180: 7175-7183. [Abstract] [Full Text] [PDF]  

Both Radioresistant and Hemopoietic Cells Promote Innate and Adaptive Immune Responses to Flagellin

Catherine J. Sanders, Daniel A. Moore, III, Ifor R. Williams, and Andrew T. Gewirtz
J Immunol 2008 180: 7184-7192. [Abstract] [Full Text] [PDF]  

Dissociation between Epitope Hierarchy and Immunoprevalence in CD8 Responses to Vaccinia Virus Western Reserve

Carla Oseroff, Bjoern Peters, Valerie Pasquetto, Magdalini Moutaftsi, John Sidney, Vijay Panchanathan, David C. Tscharke, Bernard Maillere, Howard Grey, and Alessandro Sette
J Immunol 2008 180: 7193-7202. [Abstract] [Full Text] [PDF] Data Supplement  

A Critical Precursor Frequency of Donor-Reactive CD4⁺ T Cell Help Is Required for CD8⁺ T Cell-Mediated CD28/CD154-Independent Rejection

Mandy L. Ford, Maylene E. Wagener, Samantha S. Hanna, Thomas C. Pearson, Allan D. Kirk, and Christian P. Larsen
J Immunol 2008 180: 7203-7211. [Abstract] [Full Text] [PDF]  

Effect of A_2B Adenosine Receptor Gene Ablation on Proinflammatory Adenosine Signaling in Mast Cells

Sergey Ryzhov, Rinat Zaynagetdinov, Anna E. Goldstein, Sergey V. Novitskiy, Mikhail M. Dikov, Michael R. Blackburn, Italo Biaggioni, and Igor Feoktistov
J Immunol 2008 180: 7212-7220. [Abstract] [Full Text] [PDF]  

Late Expression of Granulysin by Microbicidal CD4⁺ T Cells Requires PI3K- and STAT5-Dependent Expression of IL-2Rβ That Is Defective in HIV-Infected Patients

Chun Fu Zheng, Gareth J. Jones, Meiqing Shi, Jeremy C. D. Wiseman, Kaleb J. Marr, Byron M. Berenger, Shaunna M. Huston, M. John Gill, Alan M. Krensky, Paul Kubes, and Christopher H. Mody
J Immunol 2008 180: 7221-7229. [Abstract] [Full Text] [PDF]  

Kinetics of In Vivo Proliferation and Death of Memory and Naive CD8 T Cells: Parameter Estimation Based on 5-Bromo-2'-Deoxyuridine Incorporation in Spleen, Lymph Nodes, and Bone Marrow

Elisabetta Parretta, Giuliana Cassese, Angela Santoni, John Guardiola, Antonia Vecchio, and Francesca Di Rosa
J Immunol 2008 180: 7230-7239. [Abstract] [Full Text] [PDF]  

Activation of NF-B1 by OX40 Contributes to Antigen-Driven T Cell Expansion and Survival

Jianxun Song, Takanori So, and Michael Croft
J Immunol 2008 180: 7240-7248. [Abstract] [Full Text] [PDF]  

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

Aled Clayton, J. Paul Mitchell, Jacquelyn Court, Seamus Linnane, Malcolm D. Mason, and Zsuzsanna Tabi
J Immunol 2008 180: 7249-7258. [Abstract] [Full Text] [PDF]  

Induction of Anergy by Antibody Blockade of TCR in Myelin Oligodendrocyte Glycoprotein-Specific Cells

Heather A. Wasserman and Brian D. Evavold
J Immunol 2008 180: 7259-7264. [Abstract] [Full Text] [PDF]  

IL-7/Anti-IL-7 mAb Complexes Restore T Cell Development and Induce Homeostatic T Cell Expansion without Lymphopenia

Onur Boyman, Chris Ramsey, David M. Kim, Jonathan Sprent, and Charles D. Surh
J Immunol 2008 180: 7265-7275. [Abstract] [Full Text] [PDF]  

IL-15 Expands Unconventional CD8NK1.1⁺ T Cells but Not V14J18⁺ NKT Cells

Masaki Terabe, Yutaka Tagaya, Qing Zhu, Larry Granger, Mario Roederer, Thomas A. Waldmann, and Jay A. Berzofsky
J Immunol 2008 180: 7276-7286. [Abstract] [Full Text] [PDF]  

Circulating Myeloid Dendritic Cells of Advanced Cancer Patients Result in Reduced Activation and a Biased Cytokine Profile in Invariant NKT Cells

Hans J. J. van der Vliet, Ruojie Wang, Simon C. Yue, Henry B. Koon, Steven P. Balk, and Mark A. Exley
J Immunol 2008 180: 7287-7293. [Abstract] [Full Text] [PDF]  

Regulatory CD4⁺ T Cells Are Crucial for Preventing CD8⁺ T Cell-Mediated Autoimmunity

Maud Poitrasson-Rivière, Boris Bienvenu, Armelle Le Campion, Chantal Bécourt, Bruno Martin, and Bruno Lucas
J Immunol 2008 180: 7294-7304. [Abstract] [Full Text] [PDF]  

Regulatory CD4⁺CD25⁺Foxp3⁺ T Cells Selectively Inhibit the Spontaneous Form of Lymphopenia-Induced Proliferation of Naive T Cells

Colleen J. Winstead, Joanne M. Fraser, and Alexander Khoruts
J Immunol 2008 180: 7305-7317. [Abstract] [Full Text] [PDF]  

Regulatory Role of B Cells in a Murine Model of Allergic Airway Disease

Anurag Singh, William F. Carson, IV, Eric R. Secor, Jr, Linda A. Guernsey, Richard A. Flavell, Robert B. Clark, Roger S. Thrall, and Craig M. Schramm
J Immunol 2008 180: 7318-7326. [Abstract] [Full Text] [PDF]  

Latency-Associated Peptide Identifies a Novel CD4⁺CD25⁺ Regulatory T Cell Subset with TGFβ-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis

Mei-Ling Chen, Bo-Shiun Yan, Yoshio Bando, Vijay K. Kuchroo, and Howard L. Weiner
J Immunol 2008 180: 7327-7337. [Abstract] [Full Text] [PDF]  

Macrophage Migration Inhibitory Factor Contributes to the Immune Escape of Ovarian Cancer by Down-Regulating NKG2D

Mathias Krockenberger, Yvonne Dombrowski, Claudia Weidler, Monika Ossadnik, Arnd Hönig, Sebastian Häusler, Heike Voigt, Jürgen C. Becker, Lin Leng, Alexander Steinle, Michael Weller, Richard Bucala, Johannes Dietl, and Jörg Wischhusen
J Immunol 2008 180: 7338-7348. [Abstract] [Full Text] [PDF]  

Bacillus Calmette-Guérin and TLR4 Agonist Prevent Cardiovascular Hypertrophy and Fibrosis by Regulating Immune Microenvironment

Yu-Ying Liu, Wen-Feng Cai, Hong-Zhen Yang, Bing Cui, Zhi-Rong Chen, Han-Zhi Liu, Jun Yan, Wen Jin, Hui-Min Yan, Bing-Mu Xin, Bin Yuan, Fang Hua, and Zhuo-Wei Hu
J Immunol 2008 180: 7349-7357. [Abstract] [Full Text] [PDF]  

Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival

Yoshikane Kikushige, Goichi Yoshimoto, Toshihiro Miyamoto, Tadafumi Iino, Yasuo Mori, Hiromi Iwasaki, Hiroaki Niiro, Katsuto Takenaka, Koji Nagafuji, Mine Harada, Fumihiko Ishikawa, and Koichi Akashi
J Immunol 2008 180: 7358-7367. [Abstract] [Full Text] [PDF]  

C5a and TNF- Up-Regulate the Expression of Tissue Factor in Intra-Alveolar Neutrophils of Patients with the Acute Respiratory Distress Syndrome

Konstantinos Kambas, Maciej M. Markiewski, Ioannis A. Pneumatikos, Stavros S. Rafail, Vassiliki Theodorou, Dimitrios Konstantonis, Ioannis Kourtzelis, Michael N. Doumas, Paola Magotti, Robert A. DeAngelis, John D. Lambris, and Konstantinos D. Ritis
J Immunol 2008 180: 7368-7375. [Abstract] [Full Text] [PDF]  

Production of CCL2 by Central Nervous System Cells Regulates Development of Murine Experimental Autoimmune Encephalomyelitis through the Recruitment of TNF- and iNOS-Expressing Macrophages and Myeloid Dendritic Cells

Rukiye-Nazan E. Dogan, Adam Elhofy, and William J. Karpus
J Immunol 2008 180: 7376-7384. [Abstract] [Full Text] [PDF]  

CD43 Regulates Th2 Differentiation and Inflammation

Judy L. Cannon, Amélie Collins, Purvi D. Mody, Diwaker Balachandran, Kammi J. Henriksen, Cassandra E. Smith, Jiankun Tong, Bryan S. Clay, Stephen D. Miller, and Anne I. Sperling
J Immunol 2008 180: 7385-7393. [Abstract] [Full Text] [PDF]  

B Lymphocyte Stimulator Regulates Adaptive Immune Responses by Directly Promoting Dendritic Cell Maturation

Sook Kyung Chang, Stephen A. Mihalcik, and Diane F. Jelinek
J Immunol 2008 180: 7394-7403. [Abstract] [Full Text] [PDF]  

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

Christine A. Wells, Judith A. Salvage-Jones, Xin Li, Kelly Hitchens, Suzanne Butcher, Rachael Z. Murray, Anthony G. Beckhouse, Yu-Lan-Sandra Lo, Silvia Manzanero, Christian Cobbold, Kate Schroder, Bo Ma, Sally Orr, Lauren Stewart, Daniel Lebus, Peter Sobieszczuk, David A. Hume, Jennifer Stow, Helen Blanchard, and Robert B. Ashman
J Immunol 2008 180: 7404-7413. [Abstract] [Full Text] [PDF]  

Both Th1 and Th17 Are Immunopathogenic but Differ in Other Key Biological Activities

Catherine A. Cox, Guangpu Shi, Hongen Yin, Barbara P. Vistica, Eric F. Wawrousek, Chi-Chao Chan, and Igal Gery
J Immunol 2008 180: 7414-7422. [Abstract] [Full Text] [PDF]  

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

Jérôme Pène, Sylvie Chevalier, Laurence Preisser, Emilie Vénéreau, Marie-Hélène Guilleux, Soufiane Ghannam, Jean-Pierre Molès, Yannic Danger, Elisa Ravon, Sabine Lesaux, Hans Yssel, and Hugues Gascan
J Immunol 2008 180: 7423-7430. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Differential Expression of the Human CD8β Splice Variants and Regulation of the M-2 Isoform by Ubiquitination

Deepshi Thakral, Jessica Dobbins, Lesley Devine, and Paula B. Kavathas
J Immunol 2008 180: 7431-7442. [Abstract] [Full Text] [PDF]  

Requirement for Enhancer Specificity in Immunoglobulin Heavy Chain Locus Regulation

Igor I. Kuzin, Ludmila Bagaeva, Faith M. Young, and Andrea Bottaro
J Immunol 2008 180: 7443-7450. [Abstract] [Full Text] [PDF]  

Molecular and Immunological Characterization of a Wheat Serine Proteinase Inhibitor as a Novel Allergen in Baker's Asthma

Claudia Constantin, Santiago Quirce, Monika Grote, Alisher Touraev, Ines Swoboda, Angelika Stoecklinger, Adriano Mari, Josef Thalhamer, Erwin Heberle-Bors, and Rudolf Valenta
J Immunol 2008 180: 7451-7460. [Abstract] [Full Text] [PDF]  

IMMUNOGENETICS:

The Evolution of Multiple Isotypic IgM Heavy Chain Genes in the Shark

Victor Lee, Jing Li Huang, Ming Fai Lui, Karolina Malecek, Yuko Ohta, Arne Mooers, and Ellen Hsu
J Immunol 2008 180: 7461-7470. [Abstract] [Full Text] [PDF]  

Autoimmune Disease-Associated Histamine Receptor H₁ Alleles Exhibit Differential Protein Trafficking and Cell Surface Expression

Rajkumar Noubade, Naresha Saligrama, Karen Spach, Roxana del Rio, Elizabeth P. Blankenhorn, Theodoros Kantidakis, Graeme Milligan, Mercedes Rincon, and Cory Teuscher
J Immunol 2008 180: 7471-7479. [Abstract] [Full Text] [PDF]  

Genetic Differences in Bone Marrow-Derived Lymphoid Lineages Control Susceptibility to Experimental Autoimmune Myocarditis

Haiyan S. Li, Davinna L. Ligons, Noel R. Rose, and Mehmet L. Guler
J Immunol 2008 180: 7480-7484. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Constitutive ERK MAPK Activity Regulates Macrophage ATP Production and Mitochondrial Integrity

Martha M. Monick, Linda S. Powers, Christopher W. Barrett, Sara Hinde, Alix Ashare, Dayna J. Groskreutz, Toru Nyunoya, Mitchell Coleman, Douglas R. Spitz, and Gary W. Hunninghake
J Immunol 2008 180: 7485-7496. [Abstract] [Full Text] [PDF]  

SHIP-1 Increases Early Oxidative Burst and Regulates Phagosome Maturation in Macrophages

Lynn A. Kamen, Jonathan Levinsohn, Amy Cadwallader, Susheela Tridandapani, and Joel A. Swanson
J Immunol 2008 180: 7497-7505. [Abstract] [Full Text] [PDF] Data Supplement  

Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis

Monique Lafon, Françoise Mégret, Sven G. Meuth, Ole Simon, Myriam L. Velandia Romero, Mireille Lafage, Lieping Chen, Lena Alexopoulou, Richard A. Flavell, Christophe Prehaud, and Heinz Wiendl
J Immunol 2008 180: 7506-7515. [Abstract] [Full Text] [PDF]  

Anthrax Lethal Toxin Enhances TNF-Induced Endothelial VCAM-1 Expression via an IFN Regulatory Factor-1-Dependent Mechanism

Jason M. Warfel and Felice D'Agnillo
J Immunol 2008 180: 7516-7524. [Abstract] [Full Text] [PDF]  

Glycoprotein-Dependent and TLR2-Independent Innate Immune Recognition of Herpes Simplex Virus-1 by Dendritic Cells

Adi Reske, Gabriele Pollara, Claude Krummenacher, David R. Katz, and Benjamin M. Chain
J Immunol 2008 180: 7525-7536. [Abstract] [Full Text] [PDF]  

Leishmania braziliensis Infection Induces Dendritic Cell Activation, ISG15 Transcription, and the Generation of Protective Immune Responses

Diego A. Vargas-Inchaustegui, Lijun Xin, and Lynn Soong
J Immunol 2008 180: 7537-7545. [Abstract] [Full Text] [PDF]  

Murine Bactericidal/Permeability-Increasing Protein Inhibits the Endotoxic Activity of Lipopolysaccharide and Gram-Negative Bacteria

Irene Wittmann, Marc Schönefeld, Diana Aichele, Gerhard Groer, André Gessner, and Markus Schnare
J Immunol 2008 180: 7546-7552. [Abstract] [Full Text] [PDF]  

PDL-1 Blockade Impedes T Cell Expansion and Protective Immunity Primed by Attenuated Listeria monocytogenes

Jared H. Rowe, Tanner M. Johanns, James M. Ertelt, and Sing Sing Way
J Immunol 2008 180: 7553-7557. [Abstract] [Full Text] [PDF]  

Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection

Sarah E. Warren, Dat P. Mao, April E. Rodriguez, Edward A. Miao, and Alan Aderem
J Immunol 2008 180: 7558-7564. [Abstract] [Full Text] [PDF]  

Mast Cell Cathelicidin Antimicrobial Peptide Prevents Invasive Group A Streptococcus Infection of the Skin

Anna Di Nardo, Kenshi Yamasaki, Robert A. Dorschner, Yuping Lai, and Richard L. Gallo
J Immunol 2008 180: 7565-7573. [Abstract] [Full Text] [PDF]  

Administration of a Synthetic TLR4 Agonist Protects Mice from Pneumonic Tularemia

Annalisa Lembo, Mark Pelletier, Ravi Iyer, Michele Timko, Jan C. Dudda, T. Eoin West, Christopher B. Wilson, Adeline M. Hajjar, and Shawn J. Skerrett
J Immunol 2008 180: 7574-7581. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Differential Involvement of IB Kinases and β in Cytokine- and Insulin-Induced Mammalian Target of Rapamycin Activation Determined by Akt

Han C. Dan and Albert S. Baldwin
J Immunol 2008 180: 7582-7589. [Abstract] [Full Text] [PDF]  

Activity of Adenosine Receptors Type 1 Is Required for CX₃CL1-Mediated Neuroprotection and Neuromodulation in Hippocampal Neurons

Clotilde Lauro, Silvia Di Angelantonio, Raffaela Cipriani, Fabrizia Sobrero, Letizia Antonilli, Valentina Brusadin, Davide Ragozzino, and Cristina Limatola
J Immunol 2008 180: 7590-7596. [Abstract] [Full Text] [PDF]  

IL-10 Inhibits Cysteinyl Leukotriene-Induced Activation of Human Monocytes and Monocyte-Derived Dendritic Cells

Grzegorz Woszczek, Li-Yuan Chen, Sahrudaya Nagineni, and James H. Shelhamer
J Immunol 2008 180: 7597-7603. [Abstract] [Full Text] [PDF]  

Analysis of the Neuroinflammatory Response to TLR7 Stimulation in the Brain: Comparison of Multiple TLR7 and/or TLR8 Agonists

Niranjan B. Butchi, Susan Pourciau, Min Du, Tim W. Morgan, and Karin E. Peterson
J Immunol 2008 180: 7604-7612. [Abstract] [Full Text] [PDF]  

Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement Activation

Wei Xu, Stefan P. Berger, Leendert A. Trouw, Hetty C. de Boer, Nicole Schlagwein, Chantal Mutsaers, Mohamed R. Daha, and Cees van Kooten
J Immunol 2008 180: 7613-7621. [Abstract] [Full Text] [PDF]  

Up-Regulation and Activation of Eosinophil Integrins in Blood and Airway after Segmental Lung Antigen Challenge

Mats W. Johansson, Elizabeth A. B. Kelly, William W. Busse, Nizar N. Jarjour, and Deane F. Mosher
J Immunol 2008 180: 7622-7635. [Abstract] [Full Text] [PDF]  

Anti-Inflammatory Effects of FTY720 against Viral-Induced Immunopathology: Role of Drug-Induced Conversion of T Cells to Become Foxp3⁺ Regulators

Sharvan Sehrawat and Barry T. Rouse
J Immunol 2008 180: 7636-7647. [Abstract] [Full Text] [PDF]  

Suppressive Oligodeoxynucleotides Inhibit Silica-Induced Pulmonary Inflammation

Takashi Sato, Takeshi Shimosato, W. Gregory Alvord, and Dennis M. Klinman
J Immunol 2008 180: 7648-7654. [Abstract] [Full Text] [PDF]  

Nicotine Primarily Suppresses Lung Th2 but Not Goblet Cell and Muscle Cell Responses to Allergens

Neerad C. Mishra, Jules Rir-sima-ah, Raymond J. Langley, Shashi P. Singh, Juan C. Peña-Philippides, Takeshi Koga, Seddigheh Razani-Boroujerdi, Julie Hutt, Matthew Campen, K. Chul Kim, Yohannes Tesfaigzi, and Mohan L. Sopori
J Immunol 2008 180: 7655-7663. [Abstract] [Full Text] [PDF]  

Acute Lung Injury Induced by Lipopolysaccharide Is Independent of Complement Activation

Daniel Rittirsch, Michael A. Flierl, Danielle E. Day, Brian A. Nadeau, Stephanie R. McGuire, Laszlo M. Hoesel, Kyros Ipaktchi, Firas S. Zetoune, J. Vidya Sarma, Lin Leng, Markus S. Huber-Lang, Thomas A. Neff, Richard Bucala, and Peter A. Ward
J Immunol 2008 180: 7664-7672. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Preferential In Situ CD4⁺CD56⁺ T Cell Activation and Expansion within Human Glioblastoma

Allen Waziri, Brendan Killory, Alfred T. Ogden, III, Peter Canoll, Richard C. E. Anderson, Sally C. Kent, David E. Anderson, and Jeffrey N. Bruce
J Immunol 2008 180: 7673-7680. [Abstract] [Full Text] [PDF]  

Local Accumulation of FOXP3⁺ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata

Yuchun Cao, Jie Zhao, Zhang Lei, Shiqian Shen, Cong Liu, Dong Li, Jihong Liu, Guan-Xin Shen, Gui-Mei Zhang, Zuo-Hua Feng, and Bo Huang
J Immunol 2008 180: 7681-7686. [Abstract] [Full Text] [PDF]  

No Advantage of Cell-Penetrating Peptides over Receptor-Specific Antibodies in Targeting Antigen to Human Dendritic Cells for Cross-Presentation

Paul J. Tacken, Ben Joosten, Anita Reddy, Dayang Wu, Annemarie Eek, Peter Laverman, Anke Kretz-Rommel, Gosse J. Adema, Ruurd Torensma, and Carl G. Figdor
J Immunol 2008 180: 7687-7696. [Abstract] [Full Text] [PDF]  

Tissue Transglutaminase Activation Modulates Inflammation in Cystic Fibrosis via PPAR Down-Regulation

Luigi Maiuri, Alessandro Luciani, Ida Giardino, Valeria Raia, Valeria R. Villella, Maria D'Apolito, Massimo Pettoello-Mantovani, Stefano Guido, Carolina Ciacci, Mariano Cimmino, Olivier N. Cexus, Marco Londei, and Sonia Quaratino
J Immunol 2008 180: 7697-7705. [Abstract] [Full Text] [PDF]  

B Cell Depletion Inhibits Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice

Shiguang Yu, Robert Dunn, Marilyn R. Kehry, and Helen Braley-Mullen
J Immunol 2008 180: 7706-7713. [Abstract] [Full Text] [PDF]  

Factor VIII Hydrolysis Mediated by Anti-Factor VIII Autoantibodies in Acquired Hemophilia

Bharath Wootla, Suryasarathi Dasgupta, Jordan D. Dimitrov, Jagadeesh Bayry, Hervé Lévesque, Jeanne-Yvonne Borg, Annie Borel-Derlon, Desirazu N. Rao, Alain Friboulet, Srinivas V. Kaveri, and Sébastien Lacroix-Desmazes
J Immunol 2008 180: 7714-7720. [Abstract] [Full Text] [PDF]  

The Role of Rearrangement at the Second Ig Heavy Chain Locus in Maintaining B Cell Tolerance to DNA

Yang Liu, Lisa Li, and Chandra Mohan
J Immunol 2008 180: 7721-7727. [Abstract] [Full Text] [PDF]  

The Mer Receptor Tyrosine Kinase Is Required for the Loss of B Cell Tolerance in the Chronic Graft-versus-Host Disease Model of Systemic Lupus Erythematosus

Wen-Hai Shao, Robert A. Eisenberg, and Philip L. Cohen
J Immunol 2008 180: 7728-7735. [Abstract] [Full Text] [PDF]  

Human TCR That Incorporate CD3 Induce Highly Preferred Pairing between TCR and β Chains following Gene Transfer

Zsolt Sebestyén, Erik Schooten, Tamara Sals, Irene Zaldivar, Esther San José, Balbino Alarcón, Sara Bobisse, Antonio Rosato, János Szöllosi, Jan Willem Gratama, Ralph A. Willemsen, and Reno Debets
J Immunol 2008 180: 7736-7746. [Abstract] [Full Text] [PDF]  

HLA-DQ6 (DQB1*0601)-Restricted T Cells Protect against Experimental Autoimmune Encephalomyelitis in HLA-DR3.DQ6 Double-Transgenic Mice by Generating Anti-Inflammatory IFN-

Ashutosh Mangalam, David Luckey, Eati Basal, Marshall Behrens, Moses Rodriguez, and Chella David
J Immunol 2008 180: 7747-7756. [Abstract] [Full Text] [PDF]  

Presence of Suppressor HIV-Specific CD8⁺ T Cells Is Associated with Increased PD-1 Expression on Effector CD8⁺ T Cells

Mohamed Elrefaei, Chris A. R. Baker, Norman G. Jones, David R. Bangsberg, and Huyen Cao
J Immunol 2008 180: 7757-7763. [Abstract] [Full Text] [PDF]  

Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease

Christoph J. Blohmke, Rachel E. Victor, Aaron F. Hirschfeld, Isaac M. Elias, David G. Hancock, Cheryl R. Lane, A. George F. Davidson, Pearce G. Wilcox, Kelly D. Smith, Joerg Overhage, Robert E. W. Hancock, and Stuart E. Turvey
J Immunol 2008 180: 7764-7773. [Abstract] [Full Text] [PDF]  

CORRECTIONS:

Meso-diaminopimelic acid and meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1.

A. Uehara, Y. Fujimoto, A. Kawasaki, S. Kusumoto, K. Fukase, and H. Takada
J Immunol 2008 180: 7774. [Full Text] [PDF]  

Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo

V. Pinho, R. de Castro Russo, F. A. Amaral, L. P. de Sousa, M. M. Barsante, D. G. de Souza, J. C. Alves-Filho, D. C. Cara, J. S. Hayflick, C. Rommel, T. Ruckle, A. G. Rossi, and M. M. Teixeira
J Immunol 2008 180: 7775. [Full Text] [PDF]  

Selective estrogen receptor-β agonists repress transcription of proinflammatory genes

A. Cvoro, D. Tatomer, M.-K. Tee, T. Zogovic, H. A. Harris, and D. C. Leitman
J Immunol 2008 180: 7775. [Full Text] [PDF]  

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