IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2005 174: 587-588. [Full Text] [PDF]  

BRIEF REVIEWS:

Leukotrienes: Underappreciated Mediators of Innate Immune Responses

Marc Peters-Golden, Claudio Canetti, Peter Mancuso, and Michael J. Coffey
J Immunol 2005 174: 589-594. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: Macrophage Inhibition by Cyclic AMP (cAMP): Differential Roles of Protein Kinase A and Exchange Protein Directly Activated by cAMP-1

David M. Aronoff, Claudio Canetti, Carlos H. Serezani, Ming Luo, and Marc Peters-Golden
J Immunol 2005 174: 595-599. [Abstract] [Full Text] [PDF]  

Cutting Edge: Bcl-3 Up-Regulation by Signal 3 Cytokine (IL-12) Prolongs Survival of Antigen-Activated CD8 T Cells

Javier O. Valenzuela, Christopher D. Hammerbeck, and Matthew F. Mescher
J Immunol 2005 174: 600-604. [Abstract] [Full Text] [PDF]  

Cutting Edge: Species-Specific TLR9-Mediated Recognition of CpG and Non-CpG Phosphorothioate-Modified Oligonucleotides

Tara L. Roberts, Matthew J. Sweet, David A. Hume, and Katryn J. Stacey
J Immunol 2005 174: 605-608. [Abstract] [Full Text] [PDF]  

Cutting Edge: Role of STAT1, STAT3, and STAT5 in IFN- Responses in T Lymphocytes

Yoshinari Tanabe, Takeaki Nishibori, Leon Su, Robert M. Arduini, Darren P. Baker, and Michael David
J Immunol 2005 174: 609-613. [Abstract] [Full Text] [PDF]  

Cutting Edge: MHC Class II-Restricted Killing In Vivo during Viral Infection

Evan R. Jellison, Sung-Kwon Kim, and Raymond M. Welsh
J Immunol 2005 174: 614-618. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Peripheral "CD8 Tuning" Dynamically Modulates the Size and Responsiveness of an Antigen-Specific T Cell Pool In Vivo

Robert Maile, Catherine A. Siler, Samantha E. Kerry, Katherine E. Midkiff, Edward J. Collins, and Jeffrey A. Frelinger
J Immunol 2005 174: 619-627. [Abstract] [Full Text] [PDF]  

Heterogeneity of Expression of IgA Receptors by Human, Mouse, and Rat Eosinophils

Véronique Decot, Gaëtane Woerly, Marc Loyens, Sylvie Loiseau, Brigitte Quatannens, Monique Capron, and David Dombrowicz
J Immunol 2005 174: 628-635. [Abstract] [Full Text] [PDF]  

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

Pratima Sinha, Virginia K. Clements, and Suzanne Ostrand-Rosenberg
J Immunol 2005 174: 636-645. [Abstract] [Full Text] [PDF]  

LIGHT Is Constitutively Expressed on T and NK Cells in the Human Gut and Can Be Induced by CD2-Mediated Signaling

Offer Cohavy, Jaclyn Zhou, Carl F. Ware, and Stephan R. Targan
J Immunol 2005 174: 646-653. [Abstract] [Full Text] [PDF]  

Autocrine Regulation of T Cell Motility by Calreticulin-Thrombospondin-1 Interaction

Shu Shun Li, Anna Forslöw, and Karl-Gösta Sundqvist
J Immunol 2005 174: 654-661. [Abstract] [Full Text] [PDF]  

IL-10 Diminishes CTLA-4 Expression on Islet-Resident T Cells and Sustains Their Activation Rather Than Tolerance

Randal K. Gregg, J. Jeremiah Bell, Hyun-Hee Lee, Renu Jain, Scott J. Schoenleber, Rohit Divekar, and Habib Zaghouani
J Immunol 2005 174: 662-670. [Abstract] [Full Text] [PDF]  

Phagocytosis-Induced Apoptosis in Macrophages Is Mediated by Up-Regulation and Activation of the Bcl-2 Homology Domain 3-Only Protein Bim

Susanne Kirschnek, Songmin Ying, Silke F. Fischer, Hans Häcker, Andreas Villunger, Hubertus Hochrein, and Georg Häcker
J Immunol 2005 174: 671-679. [Abstract] [Full Text] [PDF]  

Dysregulated B7-1 and B7-2 Expression on Nonobese Diabetic Mouse B Cells Is Associated with Increased T Cell Costimulation and the Development of Insulitis

Shabbir Hussain and Terry L. Delovitch
J Immunol 2005 174: 680-687. [Abstract] [Full Text] [PDF]  

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

Creg J. Workman and Dario A. A. Vignali
J Immunol 2005 174: 688-695. [Abstract] [Full Text] [PDF]  

Vaccination with an Acidic Polymerase Epitope of Influenza Virus Elicits a Potent Antiviral T Cell Response but Delayed Clearance of an Influenza Virus Challenge

Sherry R. Crowe, Shannon C. Miller, Rachael M. Shenyo, and David L. Woodland
J Immunol 2005 174: 696-701. [Abstract] [Full Text] [PDF]  

Differential Activation of Anti-Erythrocyte and Anti-DNA Autoreactive B Lymphocytes by the Yaa Mutation

Thomas Moll, Eduardo Martinez-Soria, Marie-Laure Santiago-Raber, Hirofumi Amano, Maria Pihlgren-Bosch, Dragan Marinkovic, and Shozo Izui
J Immunol 2005 174: 702-709. [Abstract] [Full Text] [PDF]  

Induction of CD70 on Dendritic Cells through CD40 or TLR Stimulation Contributes to the Development of CD8⁺ T Cell Responses in the Absence of CD4⁺ T Cells

Timothy N. J. Bullock and Hideo Yagita
J Immunol 2005 174: 710-717. [Abstract] [Full Text] [PDF]  

T Cells Undergo Rapid ON/OFF but Not ON/OFF/ON Cycling of Cytokine Production in Response to Antigen

Gail A. Corbin and John T. Harty
J Immunol 2005 174: 718-726. [Abstract] [Full Text] [PDF]  

The Reciprocal Interaction of NK Cells with Plasmacytoid or Myeloid Dendritic Cells Profoundly Affects Innate Resistance Functions

Franca Gerosa, Andrea Gobbi, Penelope Zorzi, Stephanie Burg, Francine Briere, Giuseppe Carra, and Giorgio Trinchieri
J Immunol 2005 174: 727-734. [Abstract] [Full Text] [PDF]  

Identification of Antigen-Capturing Cells as Basophils

Matthias Mack, Martin A. Schneider, Cordula Moll, Josef Cihak, Hilke Brühl, Joachim W. Ellwart, Mark P. Hogarth, Manfred Stangassinger, and Detlef Schlöndorff
J Immunol 2005 174: 735-741. [Abstract] [Full Text] [PDF]  

TLR Ligands Can Activate Dendritic Cells to Provide a MyD88-Dependent Negative Signal for Th2 Cell Development

Jie Sun, Matthew Walsh, Alejandro V. Villarino, Laura Cervi, Christopher A. Hunter, Yongwon Choi, and Edward J. Pearce
J Immunol 2005 174: 742-751. [Abstract] [Full Text] [PDF]  

IFN- Negatively Modulates Self-Renewal of Repopulating Human Hemopoietic Stem Cells

Liping Yang, Ingunn Dybedal, David Bryder, Lars Nilsson, Ewa Sitnicka, Yutaka Sasaki, and Sten Eirik W. Jacobsen
J Immunol 2005 174: 752-757. [Abstract] [Full Text] [PDF]  

Langerhans Cells Derived from Genetically Modified Human CD34⁺ Hemopoietic Progenitors Are More Potent Than Peptide-Pulsed Langerhans Cells for Inducing Antigen-Specific CD8⁺ Cytolytic T Lymphocyte Responses

Jianda Yuan, Jean-Baptiste Latouche, John L. Reagan, Glenn Heller, Isabelle Riviere, Michel Sadelain, and James W. Young
J Immunol 2005 174: 758-766. [Abstract] [Full Text] [PDF]  

Dendritic Cells and NK Cells Stimulate Bystander T Cell Activation in Response to TLR Agonists through Secretion of IFN- and IFN-

Arun T. Kamath, Christopher E. Sheasby, and David F. Tough
J Immunol 2005 174: 767-776. [Abstract] [Full Text] [PDF]  

CpG Oligodeoxynucleotides Enhance Neonatal Resistance to Listeria Infection

Shuichi Ito, Ken J. Ishii, Mayda Gursel, Hidekazu Shirotra, Atsushi Ihata, and Dennis M. Klinman
J Immunol 2005 174: 777-782. [Abstract] [Full Text] [PDF]  

Pharmacological Targeting of Anaphylatoxin Receptors during the Effector Phase of Allergic Asthma Suppresses Airway Hyperresponsiveness and Airway Inflammation

Ralf Baelder, Barbara Fuchs, Wilfried Bautsch, Joerg Zwirner, Jörg Köhl, Heinz G Hoymann, Thomas Glaab, Veit Erpenbeck, Norbert Krug, and Armin Braun
J Immunol 2005 174: 783-789. [Abstract] [Full Text] [PDF]  

Role of CD28 in Polyclonal and Specific T and B Cell Responses Required for Protection against Blood Stage Malaria

Rosa M. Elias, Luiz R. Sardinha, Karina R. B. Bastos, Cláudia A. Zago, Ana Paula Freitas da Silva, José M. Alvarez, and Maria Regina D’Império Lima
J Immunol 2005 174: 790-799. [Abstract] [Full Text] [PDF]  

Targeted Disruption of the 2B4 Gene in Mice Reveals an In Vivo Role of 2B4 (CD244) in the Rejection of B16 Melanoma Cells

Swapnil V. Vaidya, Susan E. Stepp, Megan E. McNerney, Jae-Kyung Lee, Michael Bennett, Kyung-Mi Lee, Colin L. Stewart, Vinay Kumar, and Porunelloor A. Mathew
J Immunol 2005 174: 800-807. [Abstract] [Full Text] [PDF]  

Proinflammatory Bacterial Peptidoglycan as a Cofactor for the Development of Central Nervous System Autoimmune Disease

Lizette Visser, Hendrik Jan de Heer, Leonie A. Boven, Debby van Riel, Marjan van Meurs, Marie-José Melief, Ulrich Zähringer, Jos van Strijp, Bart N. Lambrecht, Edward E. Nieuwenhuis, and Jon D. Laman
J Immunol 2005 174: 808-816. [Abstract] [Full Text] [PDF]  

Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy

Qian Gong, Qinglin Ou, Shiming Ye, Wyne P. Lee, Jennine Cornelius, Lauri Diehl, Wei Yu Lin, Zhilan Hu, Yanmei Lu, Yongmei Chen, Yan Wu, Y. Gloria Meng, Peter Gribling, Zhonghua Lin, Kathy Nguyen, Thanhvien Tran, Yifan Zhang, Hugh Rosen, Flavius Martin, and Andrew C. Chan
J Immunol 2005 174: 817-826. [Abstract] [Full Text] [PDF]  

Uncoupling of Anergy from Developmental Arrest in Anti-Insulin B Cells Supports the Development of Autoimmune Diabetes

Carlos A. Acevedo-Suárez, Chrys Hulbert, Emily J. Woodward, and James W. Thomas
J Immunol 2005 174: 827-833. [Abstract] [Full Text] [PDF]  

Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1 System by IL-13

Chris J. Scotton, Fernando O. Martinez, Maaike J. Smelt, Marina Sironi, Massimo Locati, Alberto Mantovani, and Silvano Sozzani
J Immunol 2005 174: 834-845. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase-9 in Macrophages Induces Thymic Neovascularization following Thymocyte Apoptosis

Chikako Odaka, Masatoshi Tanioka, and Takeshi Itoh
J Immunol 2005 174: 846-853. [Abstract] [Full Text] [PDF]  

Dynamics of Dendritic Cell Phenotype and Interactions with CD4⁺ T Cells in Airway Inflammation and Tolerance

Timothy B. Oriss, Marina Ostroukhova, Carole Seguin-Devaux, Barbara Dixon-McCarthy, Donna B. Stolz, Simon C. Watkins, Brendan Pillemer, Prabir Ray, and Anuradha Ray
J Immunol 2005 174: 854-863. [Abstract] [Full Text] [PDF]  

Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammatory Cytokines

Junko Ohata, Nathan J. Zvaifler, Mitsufumi Nishio, David L. Boyle, Susan L. Kalled, Dennis A. Carson, and Thomas J. Kipps
J Immunol 2005 174: 864-870. [Abstract] [Full Text] [PDF]  

p53 Potentiation of Tumor Cell Susceptibility to CTL Involves Fas and Mitochondrial Pathways

Jérôme Thiery, Soraya Abouzahr, Guillaume Dorothee, Abdelali Jalil, Catherine Richon, Isabelle Vergnon, Fathia Mami-Chouaib, and Salem Chouaib
J Immunol 2005 174: 871-878. [Abstract] [Full Text] [PDF]  

The Expression of 11-Hydroxysteroid Dehydrogenase Type I by Lymphocytes Provides a Novel Means for Intracrine Regulation of Glucocorticoid Activities

Tian Y. Zhang, Xiaohong Ding, and Raymond A. Daynes
J Immunol 2005 174: 879-889. [Abstract] [Full Text] [PDF]  

The Notch Regulator Numb Links the Notch and TCR Signaling Pathways

Ana C. Anderson, Elizabeth A. Kitchens, Shiao Wei Chan, Charles St. Hill, Yuh Nung Jan, Weimin Zhong, and Ellen A. Robey
J Immunol 2005 174: 890-897. [Abstract] [Full Text] [PDF]  

Human CD4⁺ Effector Memory T Cells Persisting in the Microenvironment of Lung Cancer Xenografts Are Activated by Local Delivery of IL-12 to Proliferate, Produce IFN-, and Eradicate Tumor Cells

Lori Broderick, Sandra J. Yokota, Joshua Reineke, Edith Mathiowitz, Carleton C. Stewart, Maurice Barcos, Raymond J. Kelleher, Jr., and Richard B. Bankert
J Immunol 2005 174: 898-906. [Abstract] [Full Text] [PDF]  

Viral Delivery of an Epitope from Haemophilus influenzae Induces Central Nervous System Autoimmune Disease by Molecular Mimicry

J. Ludovic Croxford, Holly A. Anger, and Stephen D. Miller
J Immunol 2005 174: 907-917. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Resolution of a 16.8-Mb Autoimmunity-Regulating Rat Chromosome 4 Region into Multiple Encephalomyelitis Quantitative Trait Loci and Evidence for Epistasis

Maja Jagodic, Monica Marta, Kristina Becanovic, Jian Rong Sheng, Rita Nohra, Tomas Olsson, and Johnny C. Lorentzen
J Immunol 2005 174: 918-924. [Abstract] [Full Text] [PDF]  

Different MHC Class I Heavy Chains Compete with Each Other for Folding Independently of ₂-Microglobulin and Peptide

Sophie Tourdot, Mohamed Nejmeddine, Simon J. Powis, and Keith G. Gould
J Immunol 2005 174: 925-933. [Abstract] [Full Text] [PDF]  

The Double-Edged Sword of Activation-Induced Cytidine Deaminase

Xiaosheng Wu, Pedro Geraldes, Jeffrey L. Platt, and Marilia Cascalho
J Immunol 2005 174: 934-941. [Abstract] [Full Text] [PDF]  

Quality of Recombinant Protein Determines the Amount of Autoreactivity Detected against the Tumor-Associated Epithelial Cell Adhesion Molecule Antigen: Low Frequency of Antibodies against the Natural Protein

Oliver Schmetzer, Gerhard Moldenhauer, Rainer Riesenberg, José Ricardo Pires, Peter Schlag, and Antonio Pezzutto
J Immunol 2005 174: 942-952. [Abstract] [Full Text] [PDF]  

Tristetraprolin Down-Regulates IL-2 Gene Expression through AU-Rich Element-Mediated mRNA Decay

Rachel L. Ogilvie, Michelle Abelson, Heidi H. Hau, Irina Vlasova, Perry J. Blackshear, and Paul R. Bohjanen
J Immunol 2005 174: 953-961. [Abstract] [Full Text] [PDF]  

A Charged Amino Acid Residue in the Transmembrane/Cytoplasmic Region of Tapasin Influences MHC Class I Assembly and Maturation

Jason L. Petersen, Heather D. Hickman-Miller, Mary M. McIlhaney, Shanna E. Vargas, Anthony W. Purcell, William H. Hildebrand, and Joyce C. Solheim
J Immunol 2005 174: 962-969. [Abstract] [Full Text] [PDF]  

The Rat Expresses Two Complement Factor C4 Proteins, but Only One Isotype Is Expressed in the Liver

Christian Roos, Ralf Dressel, Bernhard Schmidt, Eberhard Günther, and Lutz Walter
J Immunol 2005 174: 970-975. [Abstract] [Full Text] [PDF]  

Vaccination with a Human High Molecular Weight Melanoma-Associated Antigen Mimotope Induces a Humoral Response Inhibiting Melanoma Cell Growth In Vitro

Stefan Wagner, Christine Hafner, Dorothee Allwardt, Joanna Jasinska, Soldano Ferrone, Christoph C. Zielinski, Otto Scheiner, Ursula Wiedermann, Hubert Pehamberger, and Heimo Breiteneder
J Immunol 2005 174: 976-982. [Abstract] [Full Text] [PDF]  

Reductions in IB and Changes in NF-B Activity during B Lymphocyte Differentiation

Stefan Doerre, Kristin Perkins Mesires, Kylle M. Daley, Thomas McCarty, Sonja Knoetig, and Ronald B. Corley
J Immunol 2005 174: 983-991. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Innate Immunity in the Human Female Reproductive Tract: Antiviral Response of Uterine Epithelial Cells to the TLR3 Agonist Poly(I:C)

Todd M. Schaefer, John V. Fahey, Jacqueline A. Wright, and Charles R. Wira
J Immunol 2005 174: 992-1002. [Abstract] [Full Text] [PDF]  

IFN- Secreted during Infection Is Necessary but Not Sufficient for Negative Feedback Regulation of IFN- Signaling by Mycobacterium tuberculosis

Savita Prabhakar, Yaming Qiao, Antony Canova, Doris B. Tse, and Richard Pine
J Immunol 2005 174: 1003-1012. [Abstract] [Full Text] [PDF]  

Abnormal Th1 Cell Differentiation and IFN- Production in T Lymphocytes from Motheaten Viable Mice Mutant for Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-1

Wen-Mei Yu, Siying Wang, Achsah D. Keegan, Mark S. Williams, and Cheng-Kui Qu
J Immunol 2005 174: 1013-1019. [Abstract] [Full Text] [PDF]  

Bacterial Lipoprotein Induces Resistance to Gram-Negative Sepsis in TLR4-Deficient Mice via Enhanced Bacterial Clearance

Gavin C. O’Brien, Jiang Huai Wang, and H. Paul Redmond
J Immunol 2005 174: 1020-1026. [Abstract] [Full Text] [PDF]  

Distinct Roles for IL-4 and IL-10 in Regulating T2 Immunity during Allergic Bronchopulmonary Mycosis

Yadira Hernandez, Shikha Arora, John R. Erb-Downward, Roderick A. McDonald, Galen B. Toews, and Gary B. Huffnagle
J Immunol 2005 174: 1027-1036. [Abstract] [Full Text] [PDF]  

Functional Heterogeneity of Memory CD4 T Cell Responses in Different Conditions of Antigen Exposure and Persistence

Alexandre Harari, Florence Vallelian, Pascal R. Meylan, and Giuseppe Pantaleo
J Immunol 2005 174: 1037-1045. [Abstract] [Full Text] [PDF]  

Restricted IgA Repertoire in Both B-1 and B-2 Cell-Derived Gut Plasmablasts

Maaike Stoel, Han-Qing Jiang, Cleo C. van Diemen, Judy C. A. M. Bun, Peter M. Dammers, M. Christine Thurnheer, Frans G. M. Kroese, John J. Cebra, and Nicolaas A. Bos
J Immunol 2005 174: 1046-1054. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

CXC Chemokine Ligand 16 Promotes Integrin-Mediated Adhesion of Liver-Infiltrating Lymphocytes to Cholangiocytes and Hepatocytes within the Inflamed Human Liver

Mathis Heydtmann, Patricia F. Lalor, J. Albertus Eksteen, Stefan G. Hübscher, Mike Briskin, and David H. Adams
J Immunol 2005 174: 1055-1062. [Abstract] [Full Text] [PDF]  

Mast Cells, Basophils, and Eosinophils Acquire Constitutive IL-4 and IL-13 Transcripts during Lineage Differentiation That Are Sufficient for Rapid Cytokine Production

André Gessner, Katja Mohrs, and Markus Mohrs
J Immunol 2005 174: 1063-1072. [Abstract] [Full Text] [PDF]  

A_2A Adenosine Receptor Induction Inhibits IFN- Production in Murine CD4⁺ T Cells

Courtney M. Lappas, Jayson M. Rieger, and Joel Linden
J Immunol 2005 174: 1073-1080. [Abstract] [Full Text] [PDF]  

TNF Receptor-Associated Factor 6 Is an Essential Mediator of CD40-Activated Proinflammatory Pathways in Monocytes and Macrophages

Lata Mukundan, Gail A. Bishop, Kimberly Z. Head, Lihua Zhang, Larry M. Wahl, and Jill Suttles
J Immunol 2005 174: 1081-1090. [Abstract] [Full Text] [PDF]  

Phospholipids Inhibit Lipopolysaccharide (LPS)-Induced Cell Activation: A Role for LPS-Binding Protein

Mareile Mueller, Klaus Brandenburg, Russ Dedrick, Andra B. Schromm, and Ulrich Seydel
J Immunol 2005 174: 1091-1096. [Abstract] [Full Text] [PDF]  

Lipoprotein I, a TLR2/4 Ligand Modulates Th2-Driven Allergic Immune Responses

Hilde Revets, Gwenda Pynaert, Johan Grooten, and Patrick De Baetselier
J Immunol 2005 174: 1097-1103. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans

Markus Huber-Lang, J. Vidya Sarma, Daniel Rittirsch, Heike Schreiber, Manfred Weiss, Michael Flierl, Ellen Younkin, Marion Schneider, Heidemarie Suger-Wiedeck, Florian Gebhard, Shannon D. McClintock, Thomas Neff, Firas Zetoune, Uwe Bruckner, Ren-Feng Guo, Peter N. Monk, and Peter A. Ward
J Immunol 2005 174: 1104-1110. [Abstract] [Full Text] [PDF]  

Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis

Shuichi Kikuchi, Liliane Fossati-Jimack, Thomas Moll, Hirofumi Amano, Eri Amano, Akinori Ida, Nabila Ibnou-Zekri, Catherine Laporte, Marie-Laure Santiago-Raber, Stephen J. Rozzo, Brian L. Kotzin, and Shozo Izui
J Immunol 2005 174: 1111-1117. [Abstract] [Full Text] [PDF]  

Requirement for CD28 May Not Be Absolute for Collagen-Induced Arthritis: Study with HLA-DQ8 Transgenic Mice

Veena Taneja, Neelam Taneja, Marshall Behrens, Marie M. Griffiths, Harvinder S. Luthra, and Chella S. David
J Immunol 2005 174: 1118-1125. [Abstract] [Full Text] [PDF]  

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