CUTTING EDGE:

Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity

Yvonne van de Wal, Yvonne Kooy, Peter van Veelen, Salvador Peña, Luisa Mearin, George Papadopoulos, and Frits Koning
J Immunol 1998 161: 1585-1588. [Abstract] [Full Text] [PDF]  

Cutting Edge: Class II Transactivator-Independent Endothelial Cell MHC Class II Gene Activation Induced by Lymphocyte Adhesion

Mark Collinge, Ruggero Pardi, and Jeffrey R. Bender
J Immunol 1998 161: 1589-1593. [Abstract] [Full Text] [PDF]  

Cutting Edge: Identification of an Additional Isoform of STAT5 Expressed in Immature Macrophages

Mary A. Lokuta, Mary Ann McDowell, and Donna M. Paulnock
J Immunol 1998 161: 1594-1597. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Antigen Processing of Two H2-IE^d-Restricted Epitopes Is Differentially Influenced by the Structural Changes in a Viral Glycoprotein

Kimberly A. Chianese-Bullock, Helena I. Russell, Christopher Moller, Walter Gerhard, John J. Monaco, and Laurence C. Eisenlohr
J Immunol 1998 161: 1599-1607. [Abstract] [Full Text] [PDF]  

Pre-B Cell Receptor-Mediated Selection of Pre-B Cells Synthesizing Functional µ Heavy Chains

Gregory H. Kline, Laura Hartwell, Gabrielle B. Beck-Engeser, Ulrike Keyna, Samantha Zaharevitz, Norman R. Klinman, and Hans-Martin Jäck
J Immunol 1998 161: 1608-1618. [Abstract] [Full Text] [PDF]  

The Role of Apoptosis in the Resolution of T Cell-Mediated Cutaneous Inflammation

Catherine H. Orteu, Len W. Poulter, Malcolm H. A. Rustin, Caroline A. Sabin, Mike Salmon, and Arne N. Akbar
J Immunol 1998 161: 1619-1629. [Abstract] [Full Text] [PDF]  

Transcription Factor E2F Controls the Reversible T Cell Growth Arrest Mediated Through WC1

Paul A. Kirkham, Eric W.-F. Lam, Haru-Hisa Takamatsu, R. Michael, and E. Parkhouse
J Immunol 1998 161: 1630-1636. [Abstract] [Full Text] [PDF]  

Extracellular Signal-Regulated Kinase-2, But Not c-Jun NH₂-Terminal Kinase, Activation Correlates with Surface IgM-Mediated Apoptosis in the WEHI 231 B Cell Line

Jong Ran Lee and Gary A. Koretzky
J Immunol 1998 161: 1637-1644. [Abstract] [Full Text] [PDF]  

A CD28-Associated Signaling Pathway Leading to Cytokine Gene Transcription and T Cell Proliferation Without TCR Engagement

Renate Siefken, Stefan Klein-Heßling, Edgar Serfling, Roland Kurrle, and Reinhard Schwinzer
J Immunol 1998 161: 1645-1651. [Abstract] [Full Text] [PDF]  

Human T Lymphocyte Proliferative Response to Resting Porcine Endothelial Cells Results from an HLA-Restricted, IL-10-Sensitive, Indirect Presentation Pathway But Also Depends on Endothelial-Specific Costimulatory Factors

Isabelle Vallée, Jean-Maurice Guillaumin, Gilles Thibault, Yves Gruel, Yvon Lebranchu, Pierre Bardos, and Hervé Watier
J Immunol 1998 161: 1652-1658. [Abstract] [Full Text] [PDF]  

Impaired Alloantigen-Mediated T Cell Apoptosis and Failure To Induce Long-Term Allograft Survival in IL-2-Deficient Mice

Zhenhua Dai, Bogumila T. Konieczny, Fady K. Baddoura, and Fadi G. Lakkis
J Immunol 1998 161: 1659-1663. [Abstract] [Full Text] [PDF]  

Low Dose TGF-ß Attenuates IL-12 Responsiveness in Murine Th Cells

James D. Gorham, Mehmet L. Güler, Domenic Fenoglio, Ueli Gubler, and Kenneth M. Murphy
J Immunol 1998 161: 1664-1670. [Abstract] [Full Text] [PDF]  

Protein Kinase C Is Involved in the Regulation of Both Signaling and Adhesion Mediated by DNAX Accessory Molecule-1 Receptor

Akira Shibuya, Lewis L. Lanier, and Joseph H. Phillips
J Immunol 1998 161: 1671-1676. [Abstract] [Full Text] [PDF]  

Assembly of MHC Class I Molecules with Biosynthesized Endoplasmic Reticulum-Targeted Peptides Is Inefficient in Insect Cells and Can Be Enhanced by Protease Inhibitors

Yuping Deng, James Gibbs, Igor Bacík, Angel Porgador, James Copeman, Paul Lehner, Bodo Ortmann, Peter Cresswell, Jack R. Bennink, and Jonathan W. Yewdell
J Immunol 1998 161: 1677-1685. [Abstract] [Full Text] [PDF]  

TCR Ligation on CD8⁺ T Cells Creates Double-Negative Cells In Vivo

Wajahat Z. Mehal and I. Nicholas Crispe
J Immunol 1998 161: 1686-1693. [Abstract] [Full Text] [PDF]  

Endogenous Basic Fibroblast Growth Factor Is Essential for Cyclin E-CDK2 Activity in Multiple External Cytokine-Induced Proliferation of AIDS-Associated Kaposi’s Sarcoma Cells: Dual Control of AIDS-Associated Kaposi’s Sarcoma Cell Growth and Cyclin E-CDK2 Activity by Endogenous and External Signals

Kaoru Murakami-Mori, Shunsuke Mori, and Shuji Nakamura
J Immunol 1998 161: 1694-1704. [Abstract] [Full Text] [PDF]  

Termination of Peripheral Tolerance to a T Cell Epitope by Heteroclitic Antigen Analogues

Ulrich Zügel, Rongfang Wang, Grace Shih, Alessandro Sette, Jeff Alexander, and Howard M. Grey
J Immunol 1998 161: 1705-1709. [Abstract] [Full Text] [PDF]  

CD1 Expression Defines Subsets of Follicular and Marginal Zone B Cells in the Spleen: ß₂-Microglobulin-Dependent and Independent Forms

Masahiko Amano, Nicole Baumgarth, Michael D. Dick, Laurent Brossay, Mitchell Kronenberg, Lee A. Herzenberg, and Samuel Strober
J Immunol 1998 161: 1710-1717. [Abstract] [Full Text] [PDF]  

Receptor-Specific Allelic Exclusion of TCRV-Chains During Development

Richard Boyd, Ivona Kozieradzki, Ann Chidgey, Hans-Willi Mittrücker, Dennis Bouchard, Emma Timms, Kenji Kishihara, Christopher J. Ong, Daniel Chui, Jamey D. Marth, Tak W. Mak, and Josef M. Penninger
J Immunol 1998 161: 1718-1727. [Abstract] [Full Text] [PDF]  

Interaction of p59^fyn Kinase with the Dynein Light Chain, Tctex-1, and Colocalization During Cytokinesis

Kerry S. Campbell, Suzanne Cooper, Mark Dessing, Sol Yates, and Annie Buder
J Immunol 1998 161: 1728-1737. [Abstract] [Full Text] [PDF]  

Requirement for Dual Signals by Anti-CD40 and IL-4 for the Induction of Nuclear Factor-B, IL-6, and IgE in Human B Lymphocytes

John D. Jeppson, Hiren R. Patel, Naoki Sakata, Joanne Domenico, Naohiro Terada, and Erwin W. Gelfand
J Immunol 1998 161: 1738-1742. [Abstract] [Full Text] [PDF]  

Regulation of Tyrosine Phosphorylation in Isolated T Cell Membrane by Inhibition of Protein Tyrosine Phosphatases

Yong-Jiu Jin, Jeff Friedman, and Steven J. Burakoff
J Immunol 1998 161: 1743-1750. [Abstract] [Full Text] [PDF]  

ß₂-Microglobulin-Dependent T Cells Are Not Necessary for Alloantigen-Induced Th2 Responses After Neonatal Induction of Lymphoid Chimerism in Mice

Gilles Foucras, Christiane Coureau, Leo Beijleveld, Philippe Druet, Abdelhadi Saoudi, and Jean-Charles Guéry
J Immunol 1998 161: 1751-1757. [Abstract] [Full Text] [PDF]  

Granulysin-Induced Apoptosis. I. Involvement of at Least Two Distinct Pathways

Susana Gamen, Dennis A. Hanson, Allan Kaspar, Javier Naval, Alan M. Krensky, and Alberto Anel
J Immunol 1998 161: 1758-1764. [Abstract] [Full Text] [PDF]  

Impaired Antibody Responses in H-2A^b Mice

Susanne Gustavsson, Susanna Hjulström-Chomez, Bo-Marcus Lidström, Niklas Ahlborg, Roland Andersson, and Birgitta Heyman
J Immunol 1998 161: 1765-1771. [Abstract] [Full Text] [PDF]  

TGF-ß Inhibits IL-12-Induced Activation of Jak-STAT Pathway in T Lymphocytes

John J. Bright and Subramaniam Sriram
J Immunol 1998 161: 1772-1777. [Abstract] [Full Text] [PDF]  

Resistance to HgCl₂-Induced Autoimmunity in Haplotype-Heterozygous Mice Is an Intrinsic Property of B Cells

Gregory A. Hanley, Joel Schiffenbauer, and Eric S. Sobel
J Immunol 1998 161: 1778-1785. [Abstract] [Full Text] [PDF]  

Antibodies to TR2 (Herpesvirus Entry Mediator), a New Member of the TNF Receptor Superfamily, Block T Cell Proliferation, Expression of Activation Markers, and Production of Cytokines

Jeremy A. Harrop, Manjula Reddy, Kimberly Dede, Michael Brigham-Burke, Sally Lyn, Kong B. Tan, Carol Silverman, Christopher Eichman, Rocco DiPrinzio, Jay Spampanato, Terence Porter, Stephen Holmes, Peter R. Young, and Alemseged Truneh
J Immunol 1998 161: 1786-1794. [Abstract] [Full Text] [PDF]  

Multiple Signaling Pathways for the Activation of JNK in Mast Cells: Involvement of Bruton’s Tyrosine Kinase, Protein Kinase C, and JNK Kinases, SEK1 and MKK7

Yuko Kawakami, Stephen E. Hartman, Pamela M. Holland, Jonathan A. Cooper, and Toshiaki Kawakami
J Immunol 1998 161: 1795-1802. [Abstract] [Full Text] [PDF]  

Cyclosporin A-Resistant Transactivation of the IL-2 Promoter Requires Activity of Okadaic Acid-Sensitive Serine/Threonine Phosphatases

Gabriele Nebl, Stefan C. Meuer, and Yvonne Samstag
J Immunol 1998 161: 1803-1810. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Characterization of a Mobile Stat6 Activation Motif in the Human IL-4 Receptor

John J. Ryan, Lisa J. McReynolds, Hua Huang, Keats Nelms, and William E. Paul
J Immunol 1998 161: 1811-1821. [Abstract] [Full Text] [PDF]  

Synergistic Activation of the Germline Promoter Mediated by Stat6 and C/EBPß

Thomas Mikita, Masae Kurama, and Ulrike Schindler
J Immunol 1998 161: 1822-1828. [Abstract] [Full Text] [PDF]  

Aspects of Antigen Mimicry Revealed by Immunization with a Peptide Mimetic of Cryptococcus neoformans Polysaccharide

Philippe Valadon, Gabriel Nussbaum, Jin Oh, and Matthew D. Scharff
J Immunol 1998 161: 1829-1836. [Abstract] [Full Text] [PDF]  

Translational Control of MHC Class II I-A Molecules by IFN-

Eduard Goñalons, Marta Barrachina, José A. García-Sanz, and Antonio Celada
J Immunol 1998 161: 1837-1843. [Abstract] [Full Text] [PDF]  

The Invariant Chain Gene Intronic Enhancer Shows Homology to Class II Promoter Elements

Bethany Beilue Moore, Zhu Alexander Cao, Theresa L. McRae, Colleen H. Woo, Sarah Conley, and Patricia P. Jones
J Immunol 1998 161: 1844-1852. [Abstract] [Full Text] [PDF]  

Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells

Susan Adams, Luc J. W. van der Laan, Elizabeth Vernon-Wilson, Chantal Renardel de Lavalette, Ed A. Döpp, Christine D. Dijkstra, David L. Simmons, and Timo K. van den Berg
J Immunol 1998 161: 1853-1859. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

New Genetic Loci That Control Susceptibility and Symptoms of Experimental Allergic Encephalomyelitis in Inbred Mice

Russell J. Butterfield, Jayce D. Sudweeks, Elizabeth P. Blankenhorn, Robert Korngold, Joseph C. Marini, John A. Todd, Randall J. Roper, and Cory Teuscher
J Immunol 1998 161: 1860-1867. [Abstract] [Full Text] [PDF]  

Rejection of H-Y Disparate Skin Grafts by Monospecific CD4⁺ Th1 and Th2 Cells: No Requirement for CD8⁺ T Cells or B Cells

Diana Zelenika, Elizabeth Adams, Andrew Mellor, Elizabeth Simpson, Phillip Chandler, Brigitte Stockinger, Herman Waldmann, and Stephen P. Cobbold
J Immunol 1998 161: 1868-1874. [Abstract] [Full Text] [PDF]  

Augmentation and Suppression of Immune Responses to an HIV-1 DNA Vaccine by Plasmid Cytokine/Ig Administration

Dan H. Barouch, Sampa Santra, Tavis D. Steenbeke, Xin X. Zheng, Helen C. Perry, Mary-Ellen Davies, Daniel C. Freed, Abie Craiu, Terry B. Strom, John W. Shiver, and Norman L. Letvin
J Immunol 1998 161: 1875-1882. [Abstract] [Full Text] [PDF]  

Identification of the Integral Membrane Protein RM3/1 on Human Monocytes as a Glucocorticoid-Inducible Member of the Scavenger Receptor Cysteine-Rich Family (CD163)

Petra Högger, Jens Dreier, Anne Droste, Friedrich Buck, and Clemens Sorg
J Immunol 1998 161: 1883-1890. [Abstract] [Full Text] [PDF]  

IL-4 Protects Adult C57BL/6 Mice from Prolonged Cryptosporidium parvum Infection: Analysis of CD4⁺ß⁺IFN-⁺ and CD4⁺ß⁺IL-4⁺ Lymphocytes in Gut-Associated Lymphoid Tissue During Resolution of Infection

Shirley A. Aguirre, Lance E. Perryman, William C. Davis, and Travis C. McGuire
J Immunol 1998 161: 1891-1900. [Abstract] [Full Text] [PDF]  

Antitumor Effect of CD40 Ligand: Elicitation of Local and Systemic Antitumor Responses by IL-12 and B7

Atsuo Nakajima, Tomohiro Kodama, Shinji Morimoto, Miyuki Azuma, Kazuyoshi Takeda, Hideo Oshima, Shin-ichi Yoshino, Hideo Yagita, and Ko Okumura
J Immunol 1998 161: 1901-1907. [Abstract] [Full Text] [PDF]  

Fc Receptors Are Not Required for Antibody-Mediated Protection Against Lethal Malaria Challenge in a Mouse Model

Harris L. Rotman, Thomas M. Daly, Raphael Clynes, and Carole A. Long
J Immunol 1998 161: 1908-1912. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Lung Injury Induced by Alloreactive Th1 Cells Is Characterized by Host-Derived Mononuclear Cell Inflammation and Activation of Alveolar Macrophages

Joan G. Clark, David K. Madtes, Robert C. Hackman, Wei Chen, Martin A. Cheever, and Paul J. Martin
J Immunol 1998 161: 1913-1920. [Abstract] [Full Text] [PDF]  

Role of Stress-Activated Mitogen-Activated Protein Kinase (p38) in ß₂-Integrin-Dependent Neutrophil Adhesion and the Adhesion-Dependent Oxidative Burst

Patricia A. Detmers, Dahua Zhou, Elizabeth Polizzi, Rolf Thieringer, William A. Hanlon, Sanskruti Vaidya, and Vinay Bansal
J Immunol 1998 161: 1921-1929. [Abstract] [Full Text] [PDF]  

CXCR1 and CXCR2 Are Rapidly Down-Modulated by Bacterial Endotoxin Through a Unique Agonist-Independent, Tyrosine Kinase-Dependent Mechanism

Masud H. Khandaker, Luoling Xu, Rahbar Rahimpour, Gordon Mitchell, Mark E. DeVries, J. Geoffrey Pickering, Sharwan K. Singhal, Ross D. Feldman, and David J. Kelvin
J Immunol 1998 161: 1930-1938. [Abstract] [Full Text] [PDF]  

The Role of Mast Cell Tryptase in Regulating Endothelial Cell Proliferation, Cytokine Release, and Adhesion Molecule Expression: Tryptase Induces Expression of mRNA for IL-1ß and IL-8 and Stimulates the Selective Release of IL-8 from Human Umbilical Vein Endothelial Cells

Steven J. Compton, Jennifer A. Cairns, Stephen T. Holgate, and Andrew F. Walls
J Immunol 1998 161: 1939-1946. [Abstract] [Full Text] [PDF]  

Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells

Thomas Luft, Ken C. Pang, Elisabeth Thomas, Paul Hertzog, Derek N. J. Hart, Joseph Trapani, and Jonathan Cebon
J Immunol 1998 161: 1947-1953. [Abstract] [Full Text] [PDF]  

Activation of the Epidermal Platelet-Activating Factor Receptor Results in Cytokine and Cyclooxygenase-2 Biosynthesis

Yong Pei, Lisa A. Barber, Robert C. Murphy, Christopher A. Johnson, Susan W. Kelley, Lady C. Dy, Richard H. Fertel, Thanh M. Nguyen, David A. Williams, and Jeffrey B. Travers
J Immunol 1998 161: 1954-1961. [Abstract] [Full Text] [PDF]  

IL-5 Production by NK Cells Contributes to Eosinophil Infiltration in a Mouse Model of Allergic Inflammation

Christoph Walker, James Checkel, Salvatore Cammisuli, Paul J. Leibson, and Gerald J. Gleich
J Immunol 1998 161: 1962-1969. [Abstract] [Full Text] [PDF]  

Inducible Nitric Oxide: An Autoregulatory Feedback Inhibitor of Vascular Inflammation

Hai-Bing Peng, Martin Spiecker, and James K. Liao
J Immunol 1998 161: 1970-1976. [Abstract] [Full Text] [PDF]  

IL-2 Receptor -Chain Expression Is Independently Regulated in Primary and Secondary Lymphoid Organs

Christophe Demaison, Laurence Fiette, Valérie Blanchetière, Anneliese Schimpl, Jacques Thèze, and P. Froussard
J Immunol 1998 161: 1977-1982. [Abstract] [Full Text] [PDF]  

Initial Cytokine Exposure Determines Function of Macrophages and Renders Them Unresponsive to Other Cytokines

Lars-Peter Erwig, David C. Kluth, Garry M. Walsh, and Andrew J. Rees
J Immunol 1998 161: 1983-1988. [Abstract] [Full Text] [PDF]  

IFNs Are Critical Regulators of IL-1 Receptor Antagonist and IL-1 Expression in Human Microglia

Judy S. H. Liu, Terry D. Amaral, Celia F. Brosnan, and Sunhee C. Lee
J Immunol 1998 161: 1989-1996. [Abstract] [Full Text] [PDF]  

Characterization of a Low Molecular Weight Isoform of IL-1 Receptor Antagonist

Mark Malyak, Joel M. Guthridge, Kenneth R. Hance, Steven K. Dower, John H. Freed, and William P. Arend
J Immunol 1998 161: 1997-2003. [Abstract] [Full Text] [PDF]  

The Differential Production of Three Forms of IL-1 Receptor Antagonist by Human Neutrophils and Monocytes

Mark Malyak, Michael F. Smith, Jr., Ashley A. Abel, Kenneth R. Hance, and William P. Arend
J Immunol 1998 161: 2004-2010. [Abstract] [Full Text] [PDF]  

IFN- Priming of Human Monocytes Differentially Regulates Gram-Positive and Gram-Negative Bacteria-Induced IL-10 Release and Selectively Enhances IL-12p70, CD80, and MHC Class I Expression

Patrice Hermann, Manuel Rubio, Toshi Nakajima, Guy Delespesse, and Marika Sarfati
J Immunol 1998 161: 2011-2018. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Molecular Analysis of Polyreactive Monoclonal Antibodies from Rheumatic Carditis: Human Anti-N-Acetylglucosamine/Anti-Myosin Antibody V Region Genes

Elisabeth E. Adderson, Alexander R. Shikhman, Kent E. Ward, and Madeleine W. Cunningham
J Immunol 1998 161: 2020-2031. [Abstract] [Full Text] [PDF]  

HLA-DQ6 and HLA-DQ8 Transgenic Mice Respond to Ragweed Allergens and Recognize a Distinct Set of Epitopes on Short and Giant Ragweed Group 5 Antigens

Svetlana P. Chapoval, Teresa Neeno, Christopher J. Krco, Eric V. Marietta, Jerry Harders, and Chella S. David
J Immunol 1998 161: 2032-2037. [Abstract] [Full Text] [PDF]  

Anti-ß₂-Glycoprotein I Autoantibodies from Patients with the "Antiphospholipid" Syndrome Bind to ß₂-Glycoprotein I with Low Affinity: Dimerization of ß₂-Glycoprotein I Induces a Significant Increase in Anti-ß₂-Glycoprotein I Antibody Affinity

Yonghua Sheng, David A. Kandiah, and Steven A. Krilis
J Immunol 1998 161: 2038-2043. [Abstract] [Full Text] [PDF]  

Induction of Species-Specific Host Accommodation in the Hamster-to-Rat Xenotransplantation Model

Dengping Yin, Lian Li Ma, Leonard Blinder, JiKun Shen, Howard Sankary, James W. Williams, and Anita S.-F. Chong
J Immunol 1998 161: 2044-2051. [Abstract] [Full Text] [PDF]  

EAE TCR Motifs and Antigen Recognition in Myelin Basic Protein-Induced Anterior Uveitis in Lewis Rats

Abigail C. Buenafe, Halina Offner, Michael Machnicki, Heather Elerding, Kirsten Adlard, Ray Jacobs, Arthur A. Vandenbark, and Grazyna Adamus
J Immunol 1998 161: 2052-2059. [Abstract] [Full Text] [PDF]  

Primary Th1 Cell Immunization Against HIVgp160 in SCID-hu Mice Coengrafted with Peripheral Blood Lymphocytes and Skin

Nadirah Delhem, Fabienne Hadida, Guy Gorochov, Françoise Carpentier, Jean-Pierre de Cavel, Jean-François Andréani, Brigitte Autran, and Jean-Yves Cesbron
J Immunol 1998 161: 2060-2069. [Abstract] [Full Text] [PDF]  

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