CUTTING EDGE:

Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma

Joel N. Kline, Thomas J. Waldschmidt, Thomas R. Businga, Jennifer E. Lemish, Joel V. Weinstock, Peter S. Thorne, and Arthur M. Krieg
J Immunol 1998 160: 2555-2559. [Abstract] [Full Text] [PDF]  

Cutting Edge: Antisense Knockdown of Inducible Nitric Oxide Synthase Inhibits Induction of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

Minzhen Ding, Ming Zhang, Joyce L. Wong, Norma E. Rogers, Louis J. Ignarro, and Rhonda R. Voskuhl
J Immunol 1998 160: 2560-2564. [Abstract] [Full Text] [PDF]  

Cutting Edge: Infection of Mice Lacking the Common Cytokine Receptor -Chain (_c) Reveals an Unexpected Role for CD4⁺ T Lymphocytes in Early IFN--Dependent Resistance to Toxoplasma gondii

Tanya Scharton-Kersten, Hiroshi Nakajima, George Yap, Alan Sher, and Warren J. Leonard
J Immunol 1998 160: 2565-2569. [Abstract] [Full Text] [PDF]  

Cutting Edge: The Induction of Acute Phase Proteins by Lipopolysaccharide Uses a Novel Pathway That Is CD14-Independent

Alain Haziot, Xing Y. Lin, Fan Zhang, and Sanna M. Goyert
J Immunol 1998 160: 2570-2572. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Induction of Autoimmune Arthritis in HLA-DR4 (DRB1*0401) Transgenic Mice by Immunization with Human and Bovine Type II Collagen

Edward F. Rosloniec1, David D. Brand, Linda K. Myers, Yukio Esaki, Karen B. Whittington, Dennis M. Zaller, Andrea Woods, John M. Stuart, and Andrew H. Kang
J Immunol 1998 160: 2573-2578. [Abstract] [Full Text] [PDF]  

Inhibition of T Cell Activation by Pharmacologic Disruption of the MEK1/ERK MAP Kinase or Calcineurin Signaling Pathways Results in Differential Modulation of Cytokine Production

Francis J. Dumont, Mary Jo Staruch, Paul Fischer, Carolyn DaSilva, and Ramon Camacho
J Immunol 1998 160: 2579-2589. [Abstract] [Full Text] [PDF]  

A Physiologic Role of Bcl-x_L Induced in Activated Macrophages

Seiji Okada, Hong Zhang, Masahiko Hatano, and Takeshi Tokuhisa
J Immunol 1998 160: 2590-2596. [Abstract] [Full Text] [PDF]  

Intracellular Pathway for the Generation of Functional MHC Class II Peptide Complexes in Immature Human Dendritic Cells

Cédric Saudrais, Danièle Spehner, Henri de la Salle, Alain Bohbot, Jean-Pierre Cazenave, Bruno Goud, Daniel Hanau, and Jean Salamero
J Immunol 1998 160: 2597-2607. [Abstract] [Full Text] [PDF]  

Generation of Intestinal Mucosal Lymphocytes in SCID Mice Reconstituted with Mature, Thymus-Derived T Cells

Victoria Camerini, Beate C. Sydora23, Richard Aranda, Chris Nguyen, Colin MacLean, William H. McBride, and Mitchell Kronenberg
J Immunol 1998 160: 2608-2618. [Abstract] [Full Text] [PDF]  

Local Synthesis of C3 Within the Splenic Lymphoid Compartment Can Reconstitute the Impaired Immune Response in C3-Deficient Mice

Michael B. Fischer, Minghe Ma, Nelson C. Hsu, and Michael C. Carroll
J Immunol 1998 160: 2619-2625. [Abstract] [Full Text] [PDF]  

Suppression of Fas/APO-1-Mediated Apoptosis by Mitogen-Activated Kinase Signaling

Tim H. Holmström, Sek C. Chow, Iina Elo, Eleanor T. Coffey, Sten Orrenius, Lea Sistonen, and John E. Eriksson
J Immunol 1998 160: 2626-2636. [Abstract] [Full Text] [PDF]  

Production of IL-10 by Human Natural Killer Cells Stimulated with IL-2 and/or IL-12

Priti T. Mehrotra, Raymond P. Donnelly, Susan Wong, Hirokazu Kanegane, Amare Geremew, Howard S. Mostowski, Keizo Furuke, Jay P. Siegel, and Eda T. Bloom
J Immunol 1998 160: 2637-2644. [Abstract] [Full Text] [PDF]  

Bone Marrow Transplantation Induces Either Clonal Deletion or Infectious Tolerance Depending on the Dose

Frederike Bemelman, Karen Honey, Elizabeth Adams, Stephen Cobbold, and Herman Waldmann
J Immunol 1998 160: 2645-2648. [Abstract] [Full Text] [PDF]  

Age-Dependent Appearance of NK1.1⁺ T Cells in the Livers of ß₂-Microglobulin Knockout and SJL Mice

Masao Murakami and William E. Paul
J Immunol 1998 160: 2649-2654. [Abstract] [Full Text] [PDF]  

A Role for Perforin in Activation-Induced Cell Death

David Spaner, Kaliannan Raju, Laszlo Radvanyi, Yunping Lin, and Richard G. Miller
J Immunol 1998 160: 2655-2664. [Abstract] [Full Text] [PDF]  

The Primary Site of CD4^-8^-B220⁺ ß T Cells in lpr Mice: The Appendix in Normal Mice

Satoshi Yamagiwa, Satoshi Sugahara, Takao Shimizu, Toshihiko Iwanaga, Yuhei Yoshida, Shigeru Honda, Hisami Watanabe, Kenji Suzuki, Hitoshi Asakura, and Toru Abo
J Immunol 1998 160: 2665-2674. [Abstract] [Full Text] [PDF]  

CD14⁺CD34⁺ Peripheral Blood Mononuclear Cells Migrate Across Endothelium and Give Rise to Immunostimulatory Dendritic Cells

Elisabetta Ferrero, Attilio Bondanza, Biagio E. Leone, Simona Manici, Alessandro Poggi, and Maria Raffaella Zocchi
J Immunol 1998 160: 2675-2683. [Abstract] [Full Text] [PDF]  

Potential Role of Resident Islet Macrophage Activation in the Initiation of Autoimmune Diabetes

Marc Arnush, Anna L. Scarim, Monique R. Heitmeier, Colleen B. Kelly, and John A. Corbett
J Immunol 1998 160: 2684-2691. [Abstract] [Full Text] [PDF]  

A Phosphorylcholine-Containing Filarial Nematode-Secreted Product Disrupts B Lymphocyte Activation by Targeting Key Proliferative Signaling Pathways

Maureen R. Deehan, Mhairi J. Frame, R. Michael E. Parkhouse, Sandra D. Seatter, Steven D. Reid, Margaret M. Harnett, and William Harnett
J Immunol 1998 160: 2692-2699. [Abstract] [Full Text] [PDF]  

Generation of Antigen-Specific Th2 Cells from Unprimed Mice In Vitro: Effects of Dexamethasone and Anti-IL-10 Antibody

Igor M. Dozmorov and Richard A. Miller
J Immunol 1998 160: 2700-2705. [Abstract] [Full Text] [PDF]  

Nucleic Acid Vaccine-Induced Immune Responses Require CD28 Costimulation and Are Regulated by CTLA4

James H. Horspool, Peter J. Perrin, Juliana B. Woodcock, Josephine H. Cox, Christopher L. King, Carl H. June, David M. Harlan, Daniel C. St. Louis, and Kelvin P. Lee
J Immunol 1998 160: 2706-2714. [Abstract] [Full Text] [PDF]  

Activation Requirements, Lytic Mechanism, and Development of a Novel Anti-CD8-Resistant CTL Population

Susan A. McCarthy, Michael S. Mainwaring, David S. Dougall, and Esi S. Lamouse-Smith
J Immunol 1998 160: 2715-2724. [Abstract] [Full Text] [PDF]  

Dependence of Antibody Somatic Diversification on Gut-Associated Lymphoid Tissue in Rabbits

Michael Vajdy, Periannan Sethupathi, and Katherine L. Knight
J Immunol 1998 160: 2725-2729. [Abstract] [Full Text] [PDF]  

Homeostasis Limits the Development of Mature CD8⁺ But Not CD4⁺ Thymocytes

Joost P. M. van Meerwijk, Samuel Marguerat, and H. Robson MacDonald
J Immunol 1998 160: 2730-2734. [Abstract] [Full Text] [PDF]  

CD4⁺, But Not CD8⁺, T Cells from Mammary Tumor-Bearing Mice Have a Down-Regulated Production of IFN-: Role of Phosphatidyl Serine

Xiaofang Cheng and Diana M. Lopez
J Immunol 1998 160: 2735-2741. [Abstract] [Full Text] [PDF]  

Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor

DanQun Guo, James D. Dunbar, Chuan He Yang, Lawrence M. Pfeffer, and David B. Donner
J Immunol 1998 160: 2742-2750. [Abstract] [Full Text] [PDF]  

A Common Immunoregulatory Locus Controls Susceptibility to Actively Induced Experimental Allergic Encephalomyelitis and Experimental Allergic Orchitis in BALB/c Mice

Cory Teuscher, William F. Hickey, Constance M. Grafer, and Kenneth S. K. Tung
J Immunol 1998 160: 2751-2756. [Abstract] [Full Text] [PDF]  

Contributions of Ea^z and Eb^z MHC Genes to Lupus Susceptibility in New Zealand Mice

Timothy J. Vyse, Stephen J. Rozzo, Charles G. Drake, Virginia B. Appel, Marianne Lemeur, Shozo Izui, Ed Palmer, and Brian L. Kotzin
J Immunol 1998 160: 2757-2766. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Functional Analysis by Site-Directed Mutagenesis of the Complex Polymorphism in Rat Transporter Associated with Antigen Processing

Edward V. Deverson, Louise Leong, Angela Seelig, W. John Coadwell, Evelyn M. Tredgett, Geoffrey W. Butcher, and Jonathan C. Howard
J Immunol 1998 160: 2767-2779. [Abstract] [Full Text] [PDF]  

Identification of an Immunodominant IgE Epitope of the Parietaria judaica Major Allergen

Paolo Colombo, Derek Kennedy2, Tracie Ramsdale, Maria A. Costa, Giovanni Duro, Vincenzo Izzo, Severo Salvadori, Remo Guerrini, Roberta Cocchiara, Mario G. Mirisola, Stephen Wood, and Domenico Geraci
J Immunol 1998 160: 2780-2785. [Abstract] [Full Text] [PDF]  

The A-Myb Transcription Factor Is a Marker of Centroblasts In Vivo

Josée Golay, Vania Broccoli, Giuseppe Lamorte, Carlo Bifulco, Carlo Parravicini, Arnold Pizzey, N. Shaun B. Thomas, Domenico Delia, Paola Ferrauti, Domenico Vitolo, and Martino Introna
J Immunol 1998 160: 2786-2793. [Abstract] [Full Text] [PDF]  

Elf-1 Regulates Basal Expression from the T Cell Antigen Receptor -Chain Gene Promoter

Barbara L. Rellahan, Jane P. Jensen, Thomas K. Howcroft, Dinah S. Singer, Ezio Bonvini, and Allan M. Weissman
J Immunol 1998 160: 2794-2801. [Abstract] [Full Text] [PDF]  

Variable Region Domain Exchange Influences the Functional Properties of IgG

Sherie L. Morrison, Stephen B. Porter, K. Ryan Trinh, Letitia A. Wims, Jerrod Denham, and Vernon T. Oi
J Immunol 1998 160: 2802-2808. [Abstract] [Full Text] [PDF]  

Direct Binding of the MHC Class I Molecule H-2L^d to CD8: Interaction with the Amino Terminus of a Mature Cell Surface Protein

Marie T. Jelonek, Brendan J. Classon, Peter J. Hudson, and David H. Margulies
J Immunol 1998 160: 2809-2814. [Abstract] [Full Text] [PDF]  

Peptide Selection by an MHC H-2K^b Class I Molecule Devoid of the Central Anchor ("C") Pocket

Alberto Molano, Hediye Erdjument-Bromage, Daved H. Fremont, Ilhem Messaoudi, Paul Tempst, and Janko Nikolic-Zugic
J Immunol 1998 160: 2815-2823. [Abstract] [Full Text] [PDF]  

Molecular Analysis of the Third Component of Canine Complement (C3) and Identification of the Mutation Responsible for Hereditary Canine C3 Deficiency

Rohan Ameratunga, Jerry A. Winkelstein, Lawrence Brody, Matthew Binns, Linda C. Cork, Paul Colombani, and David Valle
J Immunol 1998 160: 2824-2830. [Abstract] [Full Text] [PDF]  

Delineation of Selective Influences Shaping the Mutated Expressed Human Ig Heavy Chain Repertoire

Thomas Dörner, Hans-Peter Brezinschek, Sandra J. Foster, Ruth I. Brezinschek, Nancy L. Farner, and Peter E. Lipsky
J Immunol 1998 160: 2831-2841. [Abstract] [Full Text] [PDF]  

A Class I MHC-Restricted Recall Response to a Viral Peptide Is Highly Polyclonal Despite Stringent CDR3 Selection: Implications for Establishing Memory T Cell Repertoires in "Real-World" Conditions

Yuri N. Naumov, Kevin T. Hogan, Elena N. Naumova, Jeminah T. Pagel, and Jack Gorski
J Immunol 1998 160: 2842-2852. [Abstract] [Full Text] [PDF]  

Expression of MHC Class Ia and Class Ib During Ontogeny: High Expression in Epithelia and Coregulation of Class Ia and lmp7 Genes

Luisa Salter-Cid, Masaru Nonaka, and Martin F. Flajnik
J Immunol 1998 160: 2853-2861. [Abstract] [Full Text] [PDF]  

Gene Structure, Promoter Characterization, and Basis for Alternative mRNA Splicing of the Human CD58 Gene

Reinhard Wallich, Christiane Brenner, Yvonne Brand, Matthias Roux, Manuel Reister, and Stefan Meuer
J Immunol 1998 160: 2862-2871. [Abstract] [Full Text] [PDF]  

Superinduction of IL-8 in T Cells by HIV-1 Tat Protein Is Mediated Through NF-B Factors

Melanie Ott, Jennie Lee Lovett, Laurel Mueller, and Eric Verdin
J Immunol 1998 160: 2872-2880. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

The Lipophosphoglycan of Leishmania donovani Up-Regulates HIV-1 Transcription in T Cells Through the Nuclear Factor-B Elements

Richard Bernier, Benoît Barbeau, Michel J. Tremblay, and Martin Olivier
J Immunol 1998 160: 2881-2888. [Abstract] [Full Text] [PDF]  

Triggering of Peritoneal Macrophages with IFN-/ß Attenuates the Expression of Inducible Nitric Oxide Synthase Through a Decrease in NF-B Activation

Eduardo López-Collazo, Sonsoles Hortelano, Armando Rojas, and Lisardo Boscá
J Immunol 1998 160: 2889-2895. [Abstract] [Full Text] [PDF]  

CTL Effector Function Within the Central Nervous System Requires CD4⁺ T Cells

Stephen A. Stohlman, Cornelia C. Bergmann, Mark T. Lin, Daniel J. Cua, and David R. Hinton
J Immunol 1998 160: 2896-2904. [Abstract] [Full Text] [PDF]  

Distinct Homing Pathways Direct T Lymphocytes to the Genital and Intestinal Mucosae in Chlamydia-Infected Mice

Linda L. Perry, Karen Feilzer, John L. Portis, and Harlan D. Caldwell
J Immunol 1998 160: 2905-2914. [Abstract] [Full Text] [PDF]  

Resistance to Melanoma in Mice Immunized with Semiallogeneic Fibroblasts Transfected with DNA from Mouse Melanoma Cells

Edwin F. de Zoeten, Victoria Carr-Brendel, and Edward P. Cohen
J Immunol 1998 160: 2915-2922. [Abstract] [Full Text] [PDF]  

Relationship Among Immunodominance of Single CD8⁺ T Cell Epitopes, Virus Load, and Kinetics of Primary Antiviral CTL Response

Gunnar Weidt, Olaf Utermöhlen, Jochen Heukeshoven, Fritz Lehmann-Grube, and Wolfgang Deppert
J Immunol 1998 160: 2923-2931. [Abstract] [Full Text] [PDF]  

Antiviral Activities of Individual Murine IFN- Subtypes In Vivo: Intramuscular Injection of IFN Expression Constructs Reduces Cytomegalovirus Replication

Wen-Shuz Yeow, Cassandra M. Lawson, and Manfred W. Beilharz
J Immunol 1998 160: 2932-2939. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Experimental Autoimmune Encephalomyelitis Is Exacerbated in Mice Lacking the NOS2 Gene

Judy E. Fenyk-Melody, Augusta E. Garrison, Steven R. Brunnert, Jeffrey R. Weidner, Frank Shen, Beverly A. Shelton, and John S. Mudgett
J Immunol 1998 160: 2940-2946. [Abstract] [Full Text] [PDF]  

Site-Directed C3a Receptor Antibodies from Phage Display Libraries

Heiko Hawlisch, Ronald Frank, Meike Hennecke, Melanie Baensch, Bettina Sohns, Lubomir Arseniev, Wilfried Bautsch, Axel Kola, Andreas Klos, and Jörg Köhl
J Immunol 1998 160: 2947-2958. [Abstract] [Full Text] [PDF]  

Thiol-Mediated Regulation of ICAM-1 Expression in Endotoxin-Induced Acute Lung Injury

Avery B. Nathens, Richard Bitar, Ronald W.G. Watson, Thomas B. Issekutz, John C. Marshall, Alan P.B. Dackiw, and Ori D. Rotstein
J Immunol 1998 160: 2959-2966. [Abstract] [Full Text] [PDF]  

Bi-Directional Induction of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 During T Lymphoma/Endothelial Cell Contact: Implication of ICAM-1

Fawzi Aoudjit, Edouard F. Potworowski, and Yves St-Pierre
J Immunol 1998 160: 2967-2973. [Abstract] [Full Text] [PDF]  

Segregated Coupling of Phospholipases A₂, Cyclooxygenases, and Terminal Prostanoid Synthases in Different Phases of Prostanoid Biosynthesis in Rat Peritoneal Macrophages

Hiroaki Naraba, Makoto Murakami, Hideki Matsumoto, Satoko Shimbara, Akinori Ueno, Ichiro Kudo, and Sachiko Oh-ishi
J Immunol 1998 160: 2974-2982. [Abstract] [Full Text] [PDF]  

Sea Urchin Coelomocytes Specifically Express a Homologue of the Complement Component C3

Walid Z. Al-Sharif, J. Oriol Sunyer, John D. Lambris, and L. Courtney Smith
J Immunol 1998 160: 2983-2997. [Abstract] [Full Text] [PDF]  

Involvement of IL-16 in the Induction of Airway Hyper-Responsiveness and Up-Regulation of IgE in a Murine Model of Allergic Asthma

Edith M. Hessel, William W. Cruikshank, Ingrid Van Ark, Joris J. De Bie, Betty Van Esch, Gerard Hofman, Frans P. Nijkamp, David M. Center, and Antoon J. M. Van Oosterhout
J Immunol 1998 160: 2998-3005. [Abstract] [Full Text] [PDF]  

Requirement for the Alternative Pathway as Well as C4 and C2 in Complement-Dependent Hemolysis Via the Lectin Pathway

Chusana Suankratay, Xiao-Hui Zhang, Yonghong Zhang, Thomas F. Lint, and Henry Gewurz
J Immunol 1998 160: 3006-3013. [Abstract] [Full Text] [PDF]  

Functional Differences Among Multiple Isoforms of Guinea Pig Decay-Accelerating Factor

Guixian Wang, Mayumi Nonaka, Changqing He, Noriko Okada, Izumi Nakashima, and Hidechika Okada
J Immunol 1998 160: 3014-3022. [Abstract] [Full Text] [PDF]  

Regulation of Hyaluronan-Induced Chemokine Gene Expression by IL-10 and IFN- in Mouse Macrophages

Maureen R. Horton, Marie D. Burdick, Robert M. Strieter, Clare Bao, and Paul W. Noble
J Immunol 1998 160: 3023-3030. [Abstract] [Full Text] [PDF]  

Inhibition of Inducible Nitric Oxide Synthase Prevents LPS-Induced Acute Lung Injury in Dogs

Mari Numata, Shunsuke Suzuki, Naoki Miyazawa, Akira Miyashita, Yoji Nagashima, Satoshi Inoue, Takeshi Kaneko, and Takao Okubo
J Immunol 1998 160: 3031-3037. [Abstract] [Full Text] [PDF]  

Role of the Rho GTPase in Bradykinin-Stimulated Nuclear Factor-B Activation and IL-1ß Gene Expression in Cultured Human Epithelial Cells

Zhixing K. Pan, Richard D. Ye, Sandra C. Christiansen, Mark A. Jagels, Gary M. Bokoch, and Bruce L. Zuraw
J Immunol 1998 160: 3038-3045. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Oligoclonality of V1 and V2 Cells in Human Peripheral Blood Mononuclear Cells: TCR Selection Is Not Altered by Stimulation with Gram-Negative Bacteria

Jian Shen, David M. Andrews, Franco Pandolfi, Lenora A. Boyle, Catalina M. Kersten, Robert N. Blatman, and James T. Kurnick
J Immunol 1998 160: 3048-3055. [Abstract] [Full Text] [PDF]  

MHC Class I-Restricted Lysis of Human Oligodendrocytes by Myelin Basic Protein Peptide-Specific CD8 T Lymphocytes

Anna Jurewicz, William E. Biddison, and Jack P. Antel
J Immunol 1998 160: 3056-3059. [Abstract] [Full Text] [PDF]  

Androstenediol Antagonizes Herpes Simplex Virus Type 1-Induced Encephalitis Through the Augmentation of Type I IFN Production

Jennifer Daigle and Daniel J. J. Carr
J Immunol 1998 160: 3060-3066. [Abstract] [Full Text] [PDF]  

Treatment with an Anti-IL-4 Monoclonal Antibody Blocks Suppression of Collagen-Induced Arthritis in Mice by Oral Administration of Type II Collagen

Shin Yoshino
J Immunol 1998 160: 3067-3071. [Abstract] [Full Text] [PDF]  

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