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Studies of Blood Group Antibodies

III. Observations on the Physicochemical Properties of Isohemagglutinins and Isohemolysins¹

From the Department of Pathology, and the William Pepper Laboratory of Clinical Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

By a combination of chromatography and ultracentrifugation, isohemagglutinins and isohemolysins have been separated into various molecular types. Isohemagglutinins are associated with S7, ₂-globulins, S7, ₁-globulins and S19, ₁-globulins. The possibility that the antibody spectrum also includes - and ₂-globulins cannot be excluded. In general, the isohemagglutinins of the S7 class show maximal activity in the presence of anti-human globulin serum, whereas the S19 isohemagglutinins are maximally active in sodium chloride solution. Isohemolysins are found associated with S7, ₂-globulins, and with S19, ₁-globulins.

Footnotes

This investigation was supported by Research Grant, RG-6218 from the National Institutes of Health, U. S. Public Health Service.

² Assistant Professor of Pathology.

³ Associate Professor of Clinical Pathology in Medicine.