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Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues

Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia

Infection results in the formation of a circulating effector memory T cell population able to enter peripheral tissues either in the steady state or in response to localized infection. As a consequence, recall is thought to result from a phased response first involving those T cells already at the site of infection followed by the infiltration of memory cells from the wider circulation. We have recently reported that tissue-resident T cells can undergo stimulation and proliferation in response to local infection. In this study, we examine the proliferation of memory T cells newly recruited from the circulation. Our results show that although recruitment of circulating memory cells is nonspecific in nature, there is preferential proliferation of specific T cells within infected tissues. Thus, expansion represents a means of local Ag-specific enrichment of T cells recruited from a circulating memory pool of mixed specificities.

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¹ Address correspondence and reprint requests to Dr. Francis Carbone or Dr. William R. Heath, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia. E-mail addresses: fcarbone{at}unimelb.edu.au and wrheath{at}unimelb.edu.au

² Abbreviations used in this paper: gB, glycoprotein B; DRG, dorsal root ganglion; LN, lymph node.

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