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The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom
Dendritic cells have been considered an immune cell type that is specialized for the presentation of Ag to naive T cells. Considerable effort has been applied to separate their lineage, pathways of differentiation, and effectiveness in Ag presentation from those of macrophages. This review summarizes evidence that dendritic cells are a part of the mononuclear phagocyte system and are derived from a common precursor, responsive to the same growth factors (including CSF-1), express the same surface markers (including CD11c), and have no unique adaptation for Ag presentation that is not shared by other macrophages.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 Address correspondence and reprint requests to Prof. David Hume, The Roslin Institute, Roslin Biocentre, Roslin EH25 9PS, Midlothian, Scotland, U.K. E-mail address: David.Hume{at}roslin.ed.ac.uk
2 Abbreviations used in this paper: DC, dendritic cell; DTR, diphtheria toxin receptor; EGFP, enhanced GFP; Flt3L, Fms-like tyrosine kinase 3 ligand; MDP, macrophage-DC progenitor; MPS, mononuclear phagocyte system.
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