| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
* Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany;
Institut für Immunologie, Klinikum der Friedrich-Schiller-Universität Jena, Jena, Germany; and
Institute for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Mycobacterium tuberculosis remains one of the top microbial killers of humans causing 
2 million deaths annually. More than 90% of the 2 billion individuals infected never develop active disease, indicating that the immune system is able to generate mechanisms that control infection. However, the immune response generally fails to achieve sterile clearance of bacilli. Using adoptive cell transfer into C57BL/6J-Rag1tm1Mom mice (Rag1–/–), we show that regulatory T cells prevent eradication of tubercle bacilli by suppressing an otherwise efficient CD4+ T cell response. This protective CD4+ T cell response was not correlated with increased numbers of IFN-
- or TNF-
-expressing cells or general expression levels of IFN- or inducible NO synthase in infected organs compared with wild-type C57BL/6 animals. Furthermore, suppression of protection by cotransferred regulatory T cells was neither accompanied by a general increase of IL-10 expression nor by higher numbers of IL-10-producing CD4+ T cells.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 Address correspondence and reprint requests to Dr. Mischo Kursar, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany. E-mail address: kursar{at}mpiib-berlin.mpg.de
2 Mi.K. and Ma.K. contributed equally to this work.
3 Abbreviations used in this paper: Treg, regulatory T cell; fw, forward; rev, reverse; iNOS, inducible NO synthase; wt, wild type.
This article has been cited by other articles:
|
|
 |
|
  W. Seo and H. J. Ziltener CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis Blood, October 22, 2009; 114(17): 3567 - 3577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Fang, N. Ismail, T. Shelite, and D. H. Walker CD4+ CD25+ Foxp3- T-Regulatory Cells Produce both Gamma Interferon and Interleukin-10 during Acute Severe Murine Spotted Fever Rickettsiosis Infect. Immun., September 1, 2009; 77(9): 3838 - 3849. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Windish, P. L. Lin, J. T. Mattila, A. M. Green, E. O. Onuoha, L. P. Kane, and J. L. Flynn Aberrant TGF-{beta} signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis J. Leukoc. Biol., September 1, 2009; 86(3): 713 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Venkataswamy, A. Baena, M. F. Goldberg, G. Bricard, J. S. Im, J. Chan, F. Reddington, G. S. Besra, W. R. Jacobs Jr., and S. A. Porcelli Incorporation of NKT Cell-Activating Glycolipids Enhances Immunogenicity and Vaccine Efficacy of Mycobacterium bovis Bacillus Calmette-Guerin J. Immunol., August 1, 2009; 183(3): 1644 - 1656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Sharma, P. K. Saha, A. Singh, S. K. Sharma, B. Ghosh, and D. K. Mitra FoxP3+ Regulatory T Cells Suppress Effector T-Cell Function at Pathologic Site in Miliary Tuberculosis Am. J. Respir. Crit. Care Med., June 1, 2009; 179(11): 1061 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Mack, G. B. Migliori, M. Sester, H. L. Rieder, S. Ehlers, D. Goletti, A. Bossink, K. Magdorf, C. Holscher, B. Kampmann, et al. LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement Eur. Respir. J., May 1, 2009; 33(5): 956 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Ertelt, J. H. Rowe, T. M. Johanns, J. C. Lai, J. B. McLachlan, and S. S. Way Selective Priming and Expansion of Antigen-Specific Foxp3-CD4+ T Cells during Listeria monocytogenes Infection J. Immunol., March 1, 2009; 182(5): 3032 - 3038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hernandez-Pando, D. Aguilar, H. Orozco, Y. Cortez, L. R. Brunet, and G. A. Rook Orally Administered Mycobacterium vaccae Modulates Expression of Immunoregulatory Molecules in BALB/c Mice with Pulmonary Tuberculosis Clin. Vaccine Immunol., November 1, 2008; 15(11): 1730 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Forbes, C. Sander, E. O. Ronan, H. McShane, A. V. S. Hill, P. C. L. Beverley, and E. Z. Tchilian Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice J. Immunol., October 1, 2008; 181(7): 4955 - 4964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Gallegos, E. G. Pamer, and M. S. Glickman Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection J. Exp. Med., September 29, 2008; 205(10): 2359 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rausch, J. Huehn, D. Kirchhoff, J. Rzepecka, C. Schnoeller, S. Pillai, C. Loddenkemper, A. Scheffold, A. Hamann, R. Lucius, et al. Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode Infection Infect. Immun., May 1, 2008; 76(5): 1908 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Roy, P. F. Barnes, A. Garg, S. Wu, D. Cosman, and R. Vankayalapati NK Cells Lyse T Regulatory Cells That Expand in Response to an Intracellular Pathogen J. Immunol., February 1, 2008; 180(3): 1729 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Deepe Jr. and R. S. Gibbons TNF-{alpha} Antagonism Generates a Population of Antigen-Specific CD4+CD25+ T Cells That Inhibit Protective Immunity in Murine Histoplasmosis J. Immunol., January 15, 2008; 180(2): 1088 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Brown, J. L. Hurwitz, A. Zirkel, S. Surman, T. Takimoto, I. Alymova, C. Coleclough, A. Portner, P. C. Doherty, and K. S. Slobod A Recombinant Sendai Virus Is Controlled by CD4+ Effector T Cells Responding to a Secreted Human Immunodeficiency Virus Type 1 Envelope Glycoprotein J. Virol., November 15, 2007; 81(22): 12535 - 12542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Scott-Browne, S. Shafiani, G. Tucker-Heard, K. Ishida-Tsubota, J. D. Fontenot, A. Y. Rudensky, M. J. Bevan, and K. B. Urdahl Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis J. Exp. Med., September 3, 2007; 204(9): 2159 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ordway, M. Henao-Tamayo, M. Harton, G. Palanisamy, J. Troudt, C. Shanley, R. J. Basaraba, and I. M. Orme The Hypervirulent Mycobacterium tuberculosis Strain HN878 Induces a Potent TH1 Response followed by Rapid Down-Regulation J. Immunol., July 1, 2007; 179(1): 522 - 531. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
