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The Journal of Immunology, 2006, 176: 3311-3314.
Copyright © 2006 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Hormonal Milieu, Not Antigenic Specificity, Determines the Mature Phenotype of Autoreactive B Cells1

Jeganathan Venkatesh*,{dagger}, Elena Peeva{ddagger}, Xiaonan Xu{ddagger} and Betty Diamond2,*,{dagger}

Department of * Medicine and {dagger} Department of Microbiology, Columbia University, New York, NY 10032; and {ddagger} Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY 10461

Although both marginal zone and follicular B cells produce anti-DNA Abs in murine models of systemic lupus erythematosus, it has been unclear whether these distinct B cell subsets make identical or different Abs. Single-cell analysis demonstrates that the same DNA-reactive B cells can mature to either subset, depending on the hormonal environment. Anti-DNA B cells in estradiol-treated mice become marginal zone cells while identical cells from prolactin-treated mice become follicular cells. The B cell receptor signaling pathway is influenced by hormonal milieu. Thus, hormonal milieu and perhaps B cell receptor signaling, but not antigenic specificity, correlates with the differentiation pathway. These observations have implications for the pathogenesis and treatment of autoimmune disease.




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