| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037
The early events regulating antiviral CD4 responses were tracked using an adoptive transfer model. CD4+ T cell expansion was nonlinear, with a lengthy lag phase followed by 2 days of explosive proliferation. A small number of naive Ag-specific CD4+ T cells were found in nonlymphoid tissues and, in the 8 days following infection, the number of activated cells increased in all tissues analyzed, and their effector functions matured. Finally, we show that a naive mouse contains 
100 naive CD4+ precursor cells specific for a single epitope, a precursor frequency of 10–5, similar to that of naive CD8+ T cells, indicating that the 50-fold difference in size of the two responses to virus infection is determined by something other than the number of precursor cells.
This article has been cited by other articles:
|
|
 |
|
  M. O. Seedhom, E. R. Jellison, K. A. Daniels, and R. M. Welsh High Frequencies of Virus-Specific CD8+ T-Cell Precursors J. Virol., December 15, 2009; 83(24): 12907 - 12916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. V. Ravkov and M. A. Williams The Magnitude of CD4+ T Cell Recall Responses Is Controlled by the Duration of the Secondary Stimulus J. Immunol., August 15, 2009; 183(4): 2382 - 2389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Geiger, T. Duhen, A. Lanzavecchia, and F. Sallusto Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells J. Exp. Med., July 6, 2009; 206(7): 1525 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Rizzuto, T. Merghoub, D. Hirschhorn-Cymerman, C. Liu, A. M. Lesokhin, D. Sahawneh, H. Zhong, K. S. Panageas, M.-A. Perales, G. Altan-Bonnet, et al. Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response J. Exp. Med., April 13, 2009; 206(4): 849 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. L. MacLeod, A. McKee, F. Crawford, J. White, J. Kappler, and P. Marrack CD4 memory T cells divide poorly in response to antigen because of their cytokine profile PNAS, September 23, 2008; 105(38): 14521 - 14526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Fulton, M. R. Olson, and S. M. Varga Regulation of Cytokine Production by Virus-Specific CD8 T Cells in the Lungs J. Virol., August 15, 2008; 82(16): 7799 - 7811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Kotturi, I. Scott, T. Wolfe, B. Peters, J. Sidney, H. Cheroutre, M. G. von Herrath, M. J. Buchmeier, H. Grey, and A. Sette Naive Precursor Frequencies and MHC Binding Rather Than the Degree of Epitope Diversity Shape CD8+ T Cell Immunodominance J. Immunol., August 1, 2008; 181(3): 2124 - 2133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Whitmire, N. Benning, B. Eam, and J. L. Whitton Increasing the CD4+ T Cell Precursor Frequency Leads to Competition for IFN-{gamma} Thereby Degrading Memory Cell Quantity and Quality J. Immunol., May 15, 2008; 180(10): 6777 - 6785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Whitmire, B. Eam, N. Benning, and J. L. Whitton Direct Interferon-{gamma} Signaling Dramatically Enhances CD4+ and CD8+ T Cell Memory J. Immunol., July 15, 2007; 179(2): 1190 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Ford, B. H. Koehn, M. E. Wagener, W. Jiang, S. Gangappa, T. C. Pearson, and C. P. Larsen Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation J. Exp. Med., February 19, 2007; 204(2): 299 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Munroe and G. A. Bishop A Costimulatory Function for T Cell CD40 J. Immunol., January 15, 2007; 178(2): 671 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kedzierska, E. B. Day, J. Pi, S. B. Heard, P. C. Doherty, S. J. Turner, and S. Perlman Quantification of Repertoire Diversity of Influenza-Specific Epitopes with Predominant Public or Private TCR Usage J. Immunol., November 15, 2006; 177(10): 6705 - 6712. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
