The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Related articles in The JI
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Becker, T. C.
Right arrow Articles by Ahmed, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Becker, T. C.
Right arrow Articles by Ahmed, R.
The Journal of Immunology, 2005, 174: 1269-1273.
Copyright © 2005 by The American Association of Immunologists

Bone Marrow Is a Preferred Site for Homeostatic Proliferation of Memory CD8 T Cells

Todd C. Becker, Shana M. Coley, E. John Wherry and Rafi Ahmed1,2

Emory Vaccine Center, and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322

Proliferative renewal of memory CD8 T cells is essential for maintaining long-term immunity. In this study, we examined the contributions that various tissue microenvironments make toward the homeostatic proliferation of Ag-specific memory CD8 T cells. We found that dividing memory T cells were present in both lymphoid and nonlymphoid tissues. However, the bone marrow was the preferred site for proliferation and contained a major pool of the most actively dividing memory CD8 T cells. Adoptive transfer studies indicated that memory cells migrated through the bone marrow and divided there preferentially. These results show that the bone marrow is not only the source of stem cells for generating naive T cells but also provides the necessary signals for the self-renewal of memory T cells.


Related articles in The JI:

IN THIS ISSUE

The JI 2005 174: 1139-1141. [Full Text]  



This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
C Bocelli-Tyndall, L Bracci, S Schaeren, C Feder-Mengus, A Barbero, A Tyndall, and G C Spagnoli
Human bone marrow mesenchymal stem cells and chondrocytes promote and/or suppress the in vitro proliferation of lymphocytes stimulated by interleukins 2, 7 and 15
Ann Rheum Dis, August 1, 2009; 68(8): 1352 - 1359.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. J. Melenhorst, P. Scheinberg, P. K. Chattopadhyay, E. Gostick, K. Ladell, M. Roederer, N. F. Hensel, D. C. Douek, A. J. Barrett, and D. A. Price
High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow
Blood, March 5, 2009; 113(10): 2238 - 2244.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Paiardini, B. Cervasi, J. C. Engram, S. N. Gordon, N. R. Klatt, A. Muthukumar, J. Else, R. S. Mittler, S. I. Staprans, D. L. Sodora, et al.
Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis
Blood, January 15, 2009; 113(3): 612 - 621.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. W. Stonier, L. J. Ma, E. F. Castillo, and K. S. Schluns
Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation
Blood, December 1, 2008; 112(12): 4546 - 4554.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. Umansky, O. Abschuetz, W. Osen, M. Ramacher, F. Zhao, M. Kato, and D. Schadendorf
Melanoma-Specific Memory T Cells Are Functionally Active in Ret Transgenic Mice without Macroscopic Tumors
Cancer Res., November 15, 2008; 68(22): 9451 - 9458.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Parretta, G. Cassese, A. Santoni, J. Guardiola, A. Vecchio, and F. Di Rosa
Kinetics of In Vivo Proliferation and Death of Memory and Naive CD8 T Cells: Parameter Estimation Based on 5-Bromo-2'-Deoxyuridine Incorporation in Spleen, Lymph Nodes, and Bone Marrow
J. Immunol., June 1, 2008; 180(11): 7230 - 7239.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. Kheradmand, P. P. Trivedi, N. A. Wolf, P. C. Roberts, and R. H. Swanborg
Characterization of a subset of bone marrow-derived natural killer cells that regulates T cell activation in rats
J. Leukoc. Biol., May 1, 2008; 83(5): 1128 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
R. K. Reeves and P. N. Fultz
Characterization of Plasmacytoid Dendritic Cells in Bone Marrow of Pig-Tailed Macaques
Clin. Vaccine Immunol., January 1, 2008; 15(1): 35 - 41.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Racanelli, M. A. Frassanito, P. Leone, C. Brunetti, S. Ruggieri, and F. Dammacco
Bone Marrow of Persistently Hepatitis C Virus-Infected Individuals Accumulates Memory CD8+ T Cells Specific for Current and Historical Viral Antigens: A Study in Patients with Benign Hematological Disorders
J. Immunol., October 15, 2007; 179(8): 5387 - 5398.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Cassese, E. Parretta, L. Pisapia, A. Santoni, J. Guardiola, and F. Di Rosa
Bone marrow CD8 cells down-modulate membrane IL-7R{alpha} expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment.
Blood, September 15, 2007; 110(6): 1960 - 1969.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
I. Kryczek, S. Wei, E. Keller, R. Liu, and W. Zou
Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
Am J Physiol Cell Physiol, March 1, 2007; 292(3): C987 - C995.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Bracci, F. Moschella, P. Sestili, V. La Sorsa, M. Valentini, I. Canini, S. Baccarini, S. Maccari, C. Ramoni, F. Belardelli, et al.
Cyclophosphamide Enhances the Antitumor Efficacy of Adoptively Transferred Immune Cells through the Induction of Cytokine Expression, B-Cell and T-Cell Homeostatic Proliferation, and Specific Tumor Infiltration
Clin. Cancer Res., January 15, 2007; 13(2): 644 - 653.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Wei, I. Kryczek, and W. Zou
Regulatory T-cell compartmentalization and trafficking
Blood, July 15, 2006; 108(2): 426 - 431.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
B. J Sedgmen, W. Dawicki, J. L Gommerman, K. Pfeffer, and T. H Watts
LIGHT is dispensable for CD4+ and CD8+ T cell and antibody responses to influenza A virus in mice
Int. Immunol., May 1, 2006; 18(5): 797 - 806.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. S. Obhrai, M. H. Oberbarnscheidt, T. W. Hand, L. Diggs, G. Chalasani, and F. G. Lakkis
Effector T Cell Differentiation and Memory T Cell Maintenance Outside Secondary Lymphoid Organs
J. Immunol., April 1, 2006; 176(7): 4051 - 4058.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Pulle, M. Vidric, and T. H. Watts
IL-15-Dependent Induction of 4-1BB Promotes Antigen-Independent CD8 Memory T Cell Survival.
J. Immunol., March 1, 2006; 176(5): 2739 - 2748.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. H. Schmitz-Winnenthal, C. Volk, K. Z'graggen, L. Galindo, D. Nummer, Y. Ziouta, M. Bucur, J. Weitz, V. Schirrmacher, M. W. Buchler, et al.
High Frequencies of Functional Tumor-Reactive T Cells in Bone Marrow and Blood of Pancreatic Cancer Patients
Cancer Res., November 1, 2005; 65(21): 10079 - 10087.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Parretta, G. Cassese, P. Barba, A. Santoni, J. Guardiola, and F. Di Rosa
CD8 Cell Division Maintaining Cytotoxic Memory Occurs Predominantly in the Bone Marrow
J. Immunol., June 15, 2005; 174(12): 7654 - 7664.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.