| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Medicine, Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030
Based primarily on in vitro data, IL-2 is believed to be the key cytokine for initiation of the cell cycle of activated T cells. However, the role of IL-2 remains unresolved for T cell responses in vivo. We examined whether the absence of IL-2-mediated signaling in CD8 T cells affected initiation of proliferation. Our results conclusively demonstrated that initial division of Ag-specific CD8 T cells following priming was IL-2 independent, regardless of the context in which Ag was presented. In contrast, the latter stage of the proliferative phase was IL-2-dependent, particularly in nonlymphoid tissues. Thus, activated CD8 T cells initially undergo IL-2-independent proliferation, but reach a critical juncture where the requirement for IL-2 as a growth factor gains prominence.
This article has been cited by other articles:
|
|
 |
|
  A. Maroof, L. Beattie, A. Kirby, M. Coles, and P. M. Kaye Dendritic Cells Matured by Inflammation Induce CD86-Dependent Priming of Naive CD8+ T Cells in the Absence of Their Cognate Peptide Antigen J. Immunol., December 1, 2009; 183(11): 7095 - 7103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. McCarron and D. J. Reen Activated Human Neonatal CD8+ T Cells Are Subject to Immunomodulation by Direct TLR2 or TLR5 Stimulation J. Immunol., January 1, 2009; 182(1): 55 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. N. D'Souza, C.-F. Chang, A. M. Fischer, M. Li, and S. M. Hedrick The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival J. Immunol., December 1, 2008; 181(11): 7617 - 7629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kamimura and M. J. Bevan Endoplasmic Reticulum Stress Regulator XBP-1 Contributes to Effector CD8+ T Cell Differentiation during Acute Infection J. Immunol., October 15, 2008; 181(8): 5433 - 5441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. L. MacLeod, A. McKee, F. Crawford, J. White, J. Kappler, and P. Marrack CD4 memory T cells divide poorly in response to antigen because of their cytokine profile PNAS, September 23, 2008; 105(38): 14521 - 14526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xiao, V. Peperzak, A. M. Keller, and J. Borst CD27 Instructs CD4+ T Cells to Provide Help for the Memory CD8+ T Cell Response after Protein Immunization J. Immunol., July 15, 2008; 181(2): 1071 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Robertson, R. J. Messer, A. B. Carmody, R. S. Mittler, C. Burlak, and K. J. Hasenkrug CD137 Costimulation of CD8+ T Cells Confers Resistance to Suppression by Virus-Induced Regulatory T Cells J. Immunol., April 15, 2008; 180(8): 5267 - 5274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yang, E. M. Wall, K. Milne, P. Theiss, P. Watson, and B. H. Nelson CD8+ T Cells Induce Complete Regression of Advanced Ovarian Cancers by an Interleukin (IL)-2/IL-15 Dependent Mechanism Clin. Cancer Res., December 1, 2007; 13(23): 7172 - 7180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Hwang, J. R. Lukens, and T. N. J. Bullock Cognate Memory CD4+ T Cells Generated with Dendritic Cell Priming Influence the Expansion, Trafficking, and Differentiation of Secondary CD8+ T Cells and Enhance Tumor Control J. Immunol., November 1, 2007; 179(9): 5829 - 5838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Filby, B. Seddon, J. Kleczkowska, R. Salmond, P. Tomlinson, M. Smida, J. A. Lindquist, B. Schraven, and R. Zamoyska Fyn Regulates the Duration of TCR Engagement Needed for Commitment to Effector Function J. Immunol., October 1, 2007; 179(7): 4635 - 4644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Blair and L. Lefrancois Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells PNAS, September 18, 2007; 104(38): 15045 - 15050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hommel and P. D. Hodgkin TCR Affinity Promotes CD8+ T Cell Expansion by Regulating Survival J. Immunol., August 15, 2007; 179(4): 2250 - 2260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kamimura and M. J. Bevan Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo J. Exp. Med., August 6, 2007; 204(8): 1803 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Casey and M. F. Mescher IL-21 Promotes Differentiation of Naive CD8 T Cells to a Unique Effector Phenotype J. Immunol., June 15, 2007; 178(12): 7640 - 7648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Carr, M. J. Carrasco, J. E. D. Thaventhiran, P. J. Bambrough, M. Kraman, A. D. Edwards, A. Al-Shamkhani, and D. T. Fearon CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation PNAS, December 19, 2006; 103(51): 19454 - 19459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Sheridan, K. M. Khanna, G. M. Frank, and R. L. Hendricks Latent Virus Influences the Generation and Maintenance of CD8+ T Cell Memory J. Immunol., December 15, 2006; 177(12): 8356 - 8364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yu and T. R. Malek Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells J. Immunol., October 15, 2006; 177(8): 5115 - 5121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pejawar-Gaddy and M. A. Alexander-Miller Ligation of CD80 Is Critical for High-Level CD25 Expression on CD8+ T Lymphocytes J. Immunol., October 1, 2006; 177(7): 4495 - 4502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Prlic, G. Hernandez-Hoyos, and M. J. Bevan Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response J. Exp. Med., September 4, 2006; 203(9): 2135 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. N. D'Souza and S. M. Hedrick Cutting Edge: Latecomer CD8 T Cells Are Imprinted with a Unique Differentiation Program J. Immunol., July 15, 2006; 177(2): 777 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Cornish, L. V. Sinclair, and D. A. Cantrell Differential regulation of T-cell growth by IL-2 and IL-15 Blood, July 15, 2006; 108(2): 600 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Antony, C. M. Paulos, M. Ahmadzadeh, A. Akpinarli, D. C. Palmer, N. Sato, A. Kaiser, C. Heinrichs, C. A. Klebanoff, Y. Tagaya, et al. Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo J. Immunol., May 1, 2006; 176(9): 5255 - 5266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Le Bon, V. Durand, E. Kamphuis, C. Thompson, S. Bulfone-Paus, C. Rossmann, U. Kalinke, and D. F. Tough Direct Stimulation of T Cells by Type I IFN Enhances the CD8+ T Cell Response during Cross-Priming. J. Immunol., April 15, 2006; 176(8): 4682 - 4689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Verdeil, D. Puthier, C. Nguyen, A.-M. Schmitt-Verhulst, and N. Auphan-Anezin STAT5-mediated signals sustain a TCR-initiated gene expression program toward differentiation of CD8 T cell effectors. J. Immunol., April 15, 2006; 176(8): 4834 - 4842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jin, D. Gong, D. Adeegbe, A. L. Bayer, C. Rolle, A. Yu, and T. R. Malek Quantitative assessment concerning the contribution of IL-2R{beta} for superantigen-mediated T cell responses in vivo Int. Immunol., April 1, 2006; 18(4): 565 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Krieg, P. Han, R. Stone, O. D. Goularte, and J. Kaye Functional Analysis of B and T Lymphocyte Attenuator Engagement on CD4+ and CD8+ T Cells J. Immunol., November 15, 2005; 175(10): 6420 - 6427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Barouch-Bentov, E. E. Lemmens, J. Hu, E. M. Janssen, N. M. Droin, J. Song, S. P. Schoenberger, and A. Altman Protein Kinase C-{theta} Is an Early Survival Factor Required for Differentiation of Effector CD8+ T Cells J. Immunol., October 15, 2005; 175(8): 5126 - 5134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Kolumam, S. Thomas, L. J. Thompson, J. Sprent, and K. Murali-Krishna Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection J. Exp. Med., September 6, 2005; 202(5): 637 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Brooks, L. Teyton, M. B. A. Oldstone, and D. B. McGavern Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection J. Virol., August 15, 2005; 79(16): 10514 - 10527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Carlow, M. J. Williams, and H. J. Ziltener Inducing P-Selectin Ligand Formation in CD8 T Cells: IL-2 and IL-12 Are Active In Vitro but Not Required In Vivo J. Immunol., April 1, 2005; 174(7): 3959 - 3966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sundstrom, S. Ota, L. Y. Dimberg, M. G. Masucci, and A. Bergqvist Hepatitis C Virus Core Protein Induces an Anergic State Characterized by Decreased Interleukin-2 Production and Perturbation of Mitogen-Activated Protein Kinase Responses J. Virol., February 15, 2005; 79(4): 2230 - 2239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Williams and M. J. Bevan Shortening the Infectious Period Does Not Alter Expansion of CD8 T Cells but Diminishes Their Capacity to Differentiate into Memory Cells J. Immunol., December 1, 2004; 173(11): 6694 - 6702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kamimura, N. Ueda, Y. Sawa, S. Hachida, T. Atsumi, T. Nakagawa, S.-i. Sawa, G.-H. Jin, H. Suzuki, K. Ishihara, et al. Evidence of a Novel IL-2/15R{beta}-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells J. Immunol., November 15, 2004; 173(10): 6041 - 6049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Teague, R. M. Tempero, S. Thomas, K. Murali-Krishna, and B. H. Nelson Proliferation and Differentiation of CD8+ T Cells in the Absence of IL-2/15 Receptor {beta}-Chain Expression or STAT5 Activation J. Immunol., September 1, 2004; 173(5): 3131 - 3139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Mihalyo, A. D. H. Doody, J. P. McAleer, E. C. Nowak, M. Long, Y. Yang, and A. J. Adler In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy J. Immunol., May 1, 2004; 172(9): 5338 - 5345. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
